Overview and Context of the Technology of Synthethic Biology. Drew Endy Stanford Bioengineering The BioBricks Foundation The Presidential Commission for the Study of Bioethical Issues Washington DC 8 July 2010. Life has not now been created from inanimate matter. Mice from dirty
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Technology of Synthethic Biology
The BioBricks Foundation
The Presidential Commission for the Study of Bioethical Issues
8 July 2010
from inanimate matter.
Mice from dirty
rags & wheat bran
“Decoupled” promulgation over time,
Replication with representation,
Natural living systems,
Direct generational descent,
Replication with error,
Synthetic genomes are a BTD (Big Technical Deal)
and information become interconvertible.
- Changes in business and distribution models
(ongoing transitions from CDs & DVDs, to MP3s & Internet TV)
- Challenges to safety & security frameworks
(from control of material, to control of information)
- Avoidance of nation state and cultural relations
(border controls for DNA sequences on the internet, really?)
- Increases in scale and pace (overloading of current practices)
2004: 10,000 bp
2010: 1,000,000 bp
DNA Construction = #1 Tech. of 21st Ctry.
2016: 100 million?
~99% Genetic Engineering:
<20 kb DNA,
~1 dozen DNA components
>8 mb DNA, ~1000+ DNA components?!
400-fold “biointegration gap,” today.
(We are relatively bad at putting the molecules of biology back together in useful ways)
Beyond synthetic genomes: We’ll need languages & grammars for writing DNA poetry
Polymerase Chain Reaction
Basic “Cut” & “Paste”
Amplify & Make Simple Changes
Read Out the Genetic Code
- We often learn best by tinkering. for writing DNA poetry
Today, most of biology remains unknown; we stand to learn
more than ever before via a synthetic approach.The Technical Ethics of Synthetic Biology
- Freedom of the (DNA) press.
There are now no sustained public investments in getting better
at building DNA; leverage over the presses can lead to
control of content (i.e., what is written).
- Institutions & individuals; hackers are community.
The tools of synthetic biology make biotechnology, today’s *most* compelling
technology, available to many. Do we enable or ostracize a future world of
“Do-It-Together” biotechnology? Let’s not overlook many basics (e.g., property rights).
- Preparedness and reconciliation.
More accidents will happen; more misuses will occur; nature is not a liberal
representative democracy; how do we make such truths not intolerable?