LABORATORIUM INTERPRETATION OF ACID-BASE & ELECTROLITES DISORDERS. dr. Husnil Kadri, M.Kes Biochemistry Departement Medical Faculty Of Andalas University Padang. Arterial Blood Gases . Aids in establishing a diagnosis Helps guide treatment plan Aids in ventilator management
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dr. Husnil Kadri, M.Kes
Medical Faculty Of Andalas University
Definition: The amount of a strong acid (like HCl) needed to bring blood to 7.40.
Normal = 0
Used to calculate the metabolic component of an acid-base disturbance.
Calculated the same way, in practice, as SID:
Buffer Base (SID) = HCO3- + A-
HCO3 calculated by pH & pCO2 (blood gas machine)
A- calculated using pH & hemoglobin (whole blood)
OR A- calculated using albumin & phos (plasma)
BE = Buffer Base – “expected buffer base”
(expected if pH = 7.4 and pCO2 = 40)
Increased pCO2 >50
Decreased HCO3 <18
Increased HCO3 >30Is it Respiratory or Metabolic?
Impaired gas exchange
Renal Tubular Acidosis
Severe hypoxemiaCauses of Acidosis
Hyperventilation due to:
Gastric suction or vomiting
HypochloremiaCauses of Alkalosis
Source: Adapted from Friedman HH. Problem-oriented medical diagnosis, 3rd ed. Boston: Little, Brown. 1983