suprarenal cortical tumors
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Suprarenal Cortical Tumors. Functional Classification of Adrenal Cortical Tumors. Endocrine hyperfunction: Cushing, Conn syndrome, Virilism, Feminisation, mixed Non-functional or non-hyperfunctional Functional status unknown. Carcinomas 3% Female predilection

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functional classification of adrenal cortical tumors
Functional Classification of Adrenal Cortical Tumors
  • Endocrine hyperfunction: Cushing, Conn syndrome, Virilism, Feminisation, mixed
  • Non-functional or non-hyperfunctional
  • Functional status unknown
carcinomas versus adenomas
Carcinomas

3%

Female predilection

80% functional: glucocorticoids

Adenomas

More common, but accidentally discovered

M:F ratio 1:1

85% non-functional

Carcinomas versus Adenomas
carcinoma v adenoma
Carcinoma V Adenoma

Histologic Criteria Value

  • Diffuse growth pattern 0.9
  • Vascular invasion 0.9
  • Tumor cell necrosis 0.7
  • Broad fibrous bands 1.0
  • Capsular invasion 0.4
  • Mitotic activity 1/10 HPF 0.6
  • Pleomorphism: moderate /marked 0.4

Hough et al 1995

non histologic criteria
Non-Histologic Criteria
  • Tumor mass> 100 g
  • Urinary 17-ketosteroids high
  • Response to ACTH
  • Cushing syndrome +- virilism
  • Weight loss
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