Laboratory Biosafety Levels. Goals. Define barriers and procedures used by laboratories to protect workers and others from infection Describe the four biosafety levels and the protective measures used by each type of laboratory when handling infectious materials
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dedicated supply and exhaust, vacuum, decontamination systems;
a recommended absence of windows (or sealed and resistant to breakage)
BSL-1: high schools, community colleges, municipal drinking water treatment facilities
BSL-2: local health departments, universities, state laboratories, private laboratories (hospitals, health care systems), industrial laboratories (clinical diagnostic companies)
BSL-3: state health departments, universities, private companies, industry, federal government (NIH, CDC)
BSL-4: only 15 facilities in the US
9 federal (CDC, NIH), 4 university (Georgia State University, University of Texas Medical Branch), 1 state, 1 private
Renovations underway at several labs, new facilities proposed at additional sites
Laboratorians have long recognized hazards of processing infectious agents
Biosafety guidelines developed to protect workers in microbiological and medical labs through a combination of safeguards including engineering controls, management policies and work practices.
Issue described differences between biosafety levels
Help you understand process labs may have to undertake to identify microorganism, why every lab cannot test for every organism
US Department of Health and Human Services, Centers for Disease Control and Prevention and National Institutes of Health. Biosafety in Microbiological and Biomedical Laboratories. 5th ed. Washington, DC: US Government Printing Office; 2007. http://www.cdc.gov/od/ohs/ biosfty/bmbl5/bmbl5toc.htm. Accessed February 6, 2008.
Clemson University Environmental Health and Safety. Biological Safety [online training]. http://ehs.clemson.edu/training/biosafety/index.html. Accessed February 6, 2008.
Centers for Disease Control and Prevention. Laboratory-Acquired West Nile Virus Infections — United States, 2002. MMWR Morb Mort Wkly Rep. 2002; 51:1133-1135. http://www.cdc.gov/mmwr/preview/ mmwrhtml/mm5150a2.htm. Accessed February 6, 2008.
United States Government Accountability Office. High-Containment Biosafety Laboratories: Preliminary Observations on the Oversight of the Proliferation of BSL-3 and BSL-4 Laboratories in the United States. Publication GAO-08-108T. http://www.gao.gov/docsearch/ abstract.php?rptno=GAO-08-108T. Published October 4, 2007.
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