Design of a Selective, Photo- Activatable de Novo Protein. H. Christopher Fry, Andreas Lehmann, Jeffery G. Saven, William F. DeGrado and Michael J. Therien NSEC DMR08-32802.
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Design of a Selective, Photo-Activatable de Novo Protein
H. Christopher Fry, Andreas Lehmann, Jeffery G. Saven, William F. DeGrado and Michael J. Therien
First example of a computationally de novo designed protein that binds selectively an emissive abiological chromohore. Design of de novo proteins that bind abiological cofactors provide a general strategy to build proteins that possess functions not seen in nature. In designed protein complexes containing abiological Zn-porphyrin cofactors, electron and energy transfer reactions can be light activated and novel nonlinear optical and photophysical properties can be controlled.