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Herbal Mixture including Ganoderma Lucidum alleviate herpetic pain. Yuko Miyamae MD.,Ph.D (1) Yasuyo Hijikata MD.,Ph.D (2). (1) Miyamae Clinic (2) Toyodo Hijikata Clinic. Introduction

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Herbal Mixture including Ganoderma Lucidum alleviate herpetic pain

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Herbal mixture including ganoderma lucidum alleviate herpetic pain

Herbal Mixture includingGanoderma Lucidum

alleviate herpetic pain

Yuko Miyamae MD.,Ph.D (1)

Yasuyo Hijikata MD.,Ph.D (2)

(1) Miyamae Clinic

(2) Toyodo Hijikata Clinic


Herbal mixture including ganoderma lucidum alleviate herpetic pain

Introduction

Hijikata et al reported that WTMCGEPP(Wisteria floribunda , Trapa natans, Miristica agrans, Coix lachryma-jobi, cultivated Ganoderma lucidum, Elfuinga applanata, tissue-cultured Panax ginseng, and Punica granatum) decreased acute herpes zoster pain with or without conventional therapies (Ref 1).

This time, we administered to patients with herpes-related pain and PHN.

Ref 1. The American J.Chin.Med, Vol.33,No4,517-523


Herbal mixture including ganoderma lucidum alleviate herpetic pain

Subjects and Methods

WTMCGEPP was added to conventional therapies to which patients did not respond sufficiently. A 78-year-old (yrs) female with acute shingles, a 54 yrs male with diabetic nephropathy under artificial dialysis, 85 yrs male and a 73 yrs male with herpes-related pain and two PHN patients (78 yrs female and 73 yrs male) are included. All of them described themselves according to the Visual Analogue Scale (VAS) .


Herbal mixture including ganoderma lucidum alleviate herpetic pain

Table 1 Action of WTMCGEPP

Herbs (dry wt g/dose) actions

Wisteria floribunda (0.38) Promote movement in channels and collaterals Remove pain

Trapa natans (0.38)Invigorate digestive function

Miristica agrans (0.38)Drain dampness

Coix semen (0.75)

Ganoderma lucidum (0.75) Tonify Qi

Elfuinga applanata (0.38) Supply essence

Panax ginseng (0.3) Provide energy which resists disease

(tissue cultured)

Punica granatum (0.38) Destroy pests

Stabilize kidney to retain the essence


Herbal mixture including ganoderma lucidum alleviate herpetic pain

Case 1

Acute herpetic pain of right upper arm:78 –year-old female

After swimming in a pool in January, the patient

experienced the beginning of shingles with pain

in the right upper arm and back.


Herbal mixture including ganoderma lucidum alleviate herpetic pain

Physiotherapies in need

Aciclo-Div*

Analgesic drug

Vidarabine Oint Betamethasone Oint

Antiviral Drug

WTMCGEPP

80

70

60

50

VAS

40

30

20

NB

Nerve Block(NB)

10

Nkcell Activity

NB

VASx10

0

2

1

6

18

8

10

12

27

11

15

4

20

9

17

Days of illness

Fig1. Clinical course of acute herpes zoster

of right upper arm of 78-year-female.

(Aciclovir,Vitamin,Neurotropin)

*

X 10


Herbal mixture including ganoderma lucidum alleviate herpetic pain

Case 2

Herpes related pain of occipital herpes zoster:54-year-old male

He developed a right occipital herpes zoster in November. He had been undertaking dialysis because of diabetic nephropathy.


Herbal mixture including ganoderma lucidum alleviate herpetic pain

TJ-7+TJ-14

WTMCGEPP

80

60

Nkcell Activity

anti-VZVabx0.1

VAS

40

Midnight Pain

20

VASx10

First

SGB+Physiotherapy

Consult

0

1

39

31

35

29

33

36

42

56

70

23

25

46

50

Days of illness

37

34

47

30

24

40

Fig2. Clinical course of herpes zoster of 54-year-male

He is undergoing dialysis because of Diabetic Neropathy.

x 10


Herbal mixture including ganoderma lucidum alleviate herpetic pain

Case 3

Herpes related pain of right facial herpes zoster:73-year-old male

On November 5th he developed a right facial herpes zoster. He was hospitalized in a public hospital for 14days without any improvement


Herbal mixture including ganoderma lucidum alleviate herpetic pain

Kallidinogenase and Vitamin B1,6,12

100

80

WTMCGEPP

100

60

VAS

40

80

20

hospitalization

VAS

60

0

56

68

43

21

86

1

36

40

Nkcell Activity

40

anti-VZVabx0.1

First

20

Consult

SGB+Physiotherapy

VASx10

0

40

47

42

49

53

68

44

51

55

86

Days of illness

52

56

41

43

45

Fig3. Clinical course of facial herpes zoster of

73-year-male.

X 10


Herbal mixture including ganoderma lucidum alleviate herpetic pain

Case 4

Herpes related pain of left lower limb:85-year-old male

He developed the shingle at 3 months after hospitalization

because of pneumonia..

He was infected with VZV and HSV.


Herbal mixture including ganoderma lucidum alleviate herpetic pain

anti-HSVabx0.1

WTMCGEPP

100

80

anti-VZVabx0.1

60

VAS

Nkcell Activity

VASx10

40

Lower limb pain

First

20

Consult

VASx10

NB

NB

abdominal pain

0

29

99

135

-123

1

3

32

44

15

21

18

51

9

-96

Days since first consult

Fig 4. Clinical course of lower limb herpes zoster (85-year-old male)

x 10


Herbal mixture including ganoderma lucidum alleviate herpetic pain

Case 5

PHN of left leg herpes zoster:78-year-old female

She had been suffering from PHN since 9 months ago at around VAS=8.


Herbal mixture including ganoderma lucidum alleviate herpetic pain

TJ-7

WTMCGEPP

80

70

anti-HSVabx0.1

80

60

60

50

VAS

VAS

Nkcell Activity

40

40

anti-VZVabx0.1

20

30

0

1

-261

24

50

27

20

First

Consult

Physiotherapy

10

VASx10

0

50

1

22

7

10

43

5

39

27

15

9

24

30

18

16

26

28

Days since first consult

Fig 5. Clinical course of left leg herpes zoster of

X10

+

NB

year-old-female(PHN)

78-


Herbal mixture including ganoderma lucidum alleviate herpetic pain

Case 6

Right femoral reginal PHN:74-year-old male

Herpes zoster developed on the right femoral region with severe pain on the 3rd of Jan. Conventional therapies were undertaken to attain a VAS=3 on the 5th of February. He was able to lead his routine life with VAS=3 until September. On 10th of October, however, the pain appeared as cool temperatures arrived.


Herbal mixture including ganoderma lucidum alleviate herpetic pain

Keishikajyutsubuto

Conventional therapy

100

Physiotherapy+etc

80

WTMCGEPP

60

VAS

40

First

Consult

20

VASx10

0

220

97

22

76

24

34

9

1

53

121

-180

23

25

37

Days after first consult

Fig 6. Clinical course of right femor herpes zoster of 74-

X 10

year-old-male(PHN)


Herbal mixture including ganoderma lucidum alleviate herpetic pain

CONCLUSION

When the conventional therapies did not work for acute herpetic pain, herpes-related pain and PHN, the addition of WTMCGEPP to conventional therapies reduced the herpetic pain. Now that there is no way to cure PHN, the addition of WTMCGEPP to conventional therapies can be a prominent method to prevent PHN.

As WTMCGEPP increased the NK cell activity in many cases(Ref 1,2).we ‘d like to clarify how it concerns in VZV infection in future.

Ref 2:Yasuhara et al.”Effect of herbal therapy on chronic herpes virus infections.”Alternative Therapies in Health and Medicine. Vol. 9, No.5, p 132-136, 2003.


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