(a)

1. (a) • 357 entries 0 50 100 150 200 250 300 350 400 Number of LGTs Amino Acid Metabolism Carbohydrate Metabolism Genetic Information Processing Nucleotide Metabolism Glycan Metabolism Cofactors and Vitamins Lipid Metabolism Membrane Transport Energy Metabolism Other Metabolic Pathways Enzyme Reactions Hypothetical Proteins (b) (c) 45% 35% Mucosal parasites (112) E. histolytica (31) 40% 30% Insect transmitted blood parasites (41) D. discoideum (27) 35% p - value = 0.063 25% 30% p - value = 0.024 20% 25% Fraction of LGTs Fraction of LGTs 20% 15% 15% 10% 10% 5% 5% 0% 0% Lipid Metabolism Lipid Metabolism Glycan Metabolism Glycan Metabolism Energy Metabolism Energy Metabolism Signal Transduction Signal Transduction Cofactors & Vitamins Cofactors & Vitamins Membrane Transport Membrane Transport Nucleotide Metabolism Nucleotide Metabolism Amino Acid Metabolism Amino Acid Metabolism Secondary Metabolites Secondary Metabolites Carbohydrate Metabolism Carbohydrate Metabolism Xenobiotics Biodegradation Xenobiotics Biodegradation Genetic Information Processing Genetic Information Processing