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MCC PRESENTATION - GMP MANUFACTURING ENVIRONMENTS. Module 3. Presented by : Deryck Smith Consulting Engineers. GMP Manufacturing Environments. Air Handling Systems HVAC Systems H eating V entilation A ir C onditioning Module 3: Types & Configurations of

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mcc presentation gmp manufacturing environments

MCC PRESENTATION - GMP MANUFACTURING ENVIRONMENTS

Module 3

Presented by :

Deryck Smith Consulting Engineers

gmp manufacturing environments
GMP Manufacturing Environments

Air Handling Systems

HVAC Systems

Heating

Ventilation

Air Conditioning

Module 3: Types & Configurations of

AC Systems

gmp manufacturing environments3
GMP Manufacturing Environments

Topics for this Module:

Putting system components together

Airflow patterns

Locations of air terminals

Airflow problems

Operator protection 

putting the components together
Putting the Components Together
  • In the last module we looked at some of the different components that can be used in an air handling system.
  • Now we will look at different ways of putting these together.
  • The systems must be correctly assembled to serve the manufacturing facility in a safe and reliable manner. 
component assembly
Component Assembly

Secondary Filter

Supply Air Fan

Cooling Coil

Primary Filter

HEPA Filter

Supply air to

Production area

Is there anything wrong with this arrangement?

component assembly6
Component Assembly

Secondary Filter

HEPA Filter

Primary Filter

Supply Air Fan

Cooling Coil

Supply air to

Production area

This looks better!

Or is it better?

component assembly7
Component Assembly

Secondary Filter

Primary Filter

Supply Air Fan

HEPA Filter

Cooling Coil

Supply air to

Production area

That’s much better!

HEPA filter must be the very last component !

full fresh air
Full Fresh Air

Humidifier

Secondary

Filter

HEPA Filter

Cooling

Coil

Supply Air Fan

Primary Filter

Exhaust

Air Fan

Secondary

Filter

Primary

Filter

HEPA Filter

re circulation air system
Re-circulation Air System

HEPA

Filter

Secondary

Filter

Primary

Filter

SA Fan

Cooling Coil

HEPA filters must be installed!

ISPE Baseline Vol. 2 #6.3.3 (d)

terminal filtration
Terminal Filtration

Sec. Filter

Primary

Filter

SA Fan

Cool Coil

Horizontal and Vertical Uni-directional flow.

airflow patterns
Airflow Patterns

Uni-directional Airflow

Turbulent

Airflow

low level extract is ideal
Low Level Extract Is Ideal

Low level extract grilles

uni directional laminar airflow protection systems 1
Uni-directional (Laminar) Airflow Protection Systems (1)

Workbench (vertical)

Cabin/ Booth

Ceiling

uni directional laminar airflow protection systems 2
Uni-directional (Laminar) Airflow Protection Systems (2)

Integrated Vertical Flow

Integrated Horizontal Flow

airflow patterns contamination
Airflow Patterns & Contamination
  • Airflow patterns play an important role in preventing contamination and cross-contamination.
  • Airflow direction is also important in providing operator protection from dust inhalation.
  • Some examples follow. 
weigh booth protection
Weigh Booth Protection

Horizontal uni-directional

airflow protects the operator.

airflow problems 1
Airflow Problems (1)

Vertical airflow out of bin!

airflow problems 2
Airflow Problems (2)

Flow reversal off table!

airflow problems 3
Airflow Problems (3)

Air deflected

off scale!

air showers
Air Showers

Air showers can be used to remove dust from operators thus preventing cross-contamination

operator protection
Operator Protection

Questions & Answers

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