Neurobiology of reward
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Neurobiology of Reward. Reward Components. Affective or Emotional Liking Facial expressions Subjective ratings in humans Motivation Wanting or craving Conditioned approach Operant responding Subjective rating or desire in humans Learning Pavlovian CS-based prediction Anticipatory CR

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Reward components
Reward Components

  • Affective or Emotional

    • Liking

      • Facial expressions

      • Subjective ratings in humans

  • Motivation

    • Wanting or craving

      • Conditioned approach

      • Operant responding

      • Subjective rating or desire in humans

  • Learning

    • Pavlovian CS-based prediction

      • Anticipatory CR

    • Operant-based CS–(response-outcome) associations

      • Goal directed behavior



Drug self administration
Drug Self-Administration

  • Self-administration paradigm

    • Positive contingency between response and injection of drug

  • DA agonists promote self-administration

  • DA agonists in brain promote strong self-administration

  • DA antagonists block self-administration of DA agonists




Reward using ebs
Reward Using EBS

  • Electrical brain stimulation (EBS) produces approach behaviors

  • Self-stimulation paradigm

    • Positive contingency: response leads to EBS

  • SS depends on electrode location


Reinforcing ebs
Reinforcing EBS

  • Medial forebrain bundle (MFB)

  • Ventral tegmental area (VTA)

  • Nucleus accumbens (NA)

  • Dopamine projection



Reinforcing ebs cont
Reinforcing EBS cont.

  • MFB stimulation supports strong responding

  • Adjust intensity, duration, and pulse frequency of EBS and change responding

  • Reinforcing effects of MFB stimulation

    • enhanced by DA agonist drugs

    • blocked by DA antagonist drugs

    • DA release increased in NA w/ EBS of MFB








Liking
Liking

Liking depends on opiates, not dopamine


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