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The Radnoti Working Heart System

The Isolated Perfused Heart System, as originated by Oscar Langendorff more than a century ago, has become a predominant technique in pharmacological and physiological research. The technique allows the examination of cardiac contractile strength (inotropic effects), heart rate (chronotropic effects) and vascular effects without the complications of an intact animal model. From its simple beginning the technique and equipment has evolved to include both constant pressure and constant flow models30073

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The Radnoti Working Heart System

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Presentation Transcript

    1. The Radnoti Working Heart System

    2. Introduction

    3. Typical Values

    4. Ready, Set, Go

    5. Pumps Overview

    6. Water Jacket Diagram

    7. Priming the System

    8. Anesthesia and Cardiac Removal

    9. Excision of the Heart

    10. Working Heart Mode To clarify, In retrograde perfusion, the heart is being fed via the aorta under pressure. As this is reverse of the normal flow pattern, the aortic valve is forced closed and perfusate is forced through the Ostia into the coronary bed.To clarify, In retrograde perfusion, the heart is being fed via the aorta under pressure. As this is reverse of the normal flow pattern, the aortic valve is forced closed and perfusate is forced through the Ostia into the coronary bed.

    11. Cannulation and Stabilization

    12. Perfusion of the Heart

    13. Working Heart Preparation To clarify, In retrograde perfusion, the heart is being fed via the aorta under pressure. As this is reverse of the normal flow pattern, the aortic valve is forced closed and perfusate is forced through the Ostia into the coronary bed.To clarify, In retrograde perfusion, the heart is being fed via the aorta under pressure. As this is reverse of the normal flow pattern, the aortic valve is forced closed and perfusate is forced through the Ostia into the coronary bed.

    14. Working Heart in Detail

    15. Working Heart in Detail cont.

    16. Working Heart in Detail cont.

    17. Working Heart in Detail cont.

    18. Switching the system to Working Heart Mode

    19. After Load Pressure

    20. After Load Pressure cont.

    21. Recommended Reading

    22. Disclaimer

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