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Pathology of skin diseases ((Dermathopathology))

Pathology of skin diseases ((Dermathopathology)). by S.S EGHBALI MD APCP. Macroscopic Terms. Macule  Pustule Papule  Wheal Nodule  Scale Plaque  Lichenification Vesicle  Excoriation Bullae  Onicholysis. Microscopic terms. Hyperkeratosis  lentiginous

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Pathology of skin diseases ((Dermathopathology))

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  1. Pathology of skin diseases((Dermathopathology)) by S.S EGHBALI MD APCP

  2. Macroscopic Terms • Macule  Pustule • Papule  Wheal • Nodule  Scale • Plaque  Lichenification • Vesicle  Excoriation • Bullae  Onicholysis

  3. Microscopic terms • Hyperkeratosis  lentiginous • Parakeratosis  Spongiosis • Acanthosis  Exocytosis • Dyskeratosis  Erosion • Acantholysis  Ulceration • Papillomatosis  Vacuolization

  4. Acute inflammatory dermatoses

  5. Urticaria (Hives) • Localized mast cell degranulation • Pruritic papules & plaques • Inflammatory cell infiltration • Edema • Dilated Vessles

  6. Acute eczematous dermatitis • Papulo vesicular & oozing & crusted lesions • Drying , Acanthosis & Hyperkeratosis • Spongiosis • Lymphocytic infiltration • Varrious types by origin

  7. Erythema multiforme • Drugs • Infections • Malignancies • C.V.D TCD 8 + (CTL) have important role

  8. Erythema multiforme • Macule , Papule , Vesicle , Bullae • Target lesion is charactristics • Lymphocytic infiltration (CD4) • Keratinocyte necrosis • Epidermal necrosis

  9. Chronic inflammatory dermatoses

  10. Psoriasis • Systemic disease • Scaly plaques • Erythroderma • Nail changes • Pustule formation • cont ….

  11. Psoriasis • High epidermal turn over • Acanthosis • Elongation of rete ridges • Thining of granular laye • Cont…

  12. Psoriasis • Auspitz ‘ s sign • Monro’s microabcess • Parakeratosis • Suprapapillary thining Activation of autoab.sandcomplement Haveimportant role in psoriasis

  13. Lichen Planus • Pruritic & Polygonal papules • Wickham’s striae • Post inflammatory pigmentation • Mouth lesion cont ….

  14. Lichen Planus • Band like infiltration • Basal cell degeneration • Saw-tooth appearance • Colloid (civatte) bodies • Hypergranulosis • Hyperkeratosis

  15. Lapus erythematosus • SLE • DLE • SCLE Humoral & cellular lmmunity and complent haveimportant role in lupus

  16. DLE • Malar rash • Discoid plaque • Scaling • Talengiectasia • Hypo & hyper pigmentation • cont ….

  17. DLE • Lymphocytic infiltration • Basal cell degeneration • Epidermal atrophy • Follicular plagging • BM thickness (Pas +) • Lupus band test

  18. Bullous Diseases

  19. Subcorneal bullae - Impetigo - Pemphigus folliaceus Suprabasal Bullae -Pemphigus Vulgaris Classification of bullousdis.

  20. Sub epidermal bullae • Bullous pemphigoid • Dermatitis herpetiform • Epidermolysis bullosa • Purphyria

  21. Pemphigus • Acantholysis • Inflammatory cell infiltration • Anti desmoglein – 3 • PA Serin protease • cont ….

  22. Pemphigus Variants • P. Vulgaris (Supra basal) • P. Vegetans (Hyperkeratosis) • P. Folliaceus (granulosa) • P. Erythematosus (Malar)

  23. Bullous Pemphigoid • Eldery Patient • Tense bullae without rupture • No sequelae • Subepidermal & nonacantholytic bullae • Lymph & PMN & EOS • Basal cell degeneration • cont ….

  24. Bullous Pemphigoid • Anti lamina lucida • Anti hemidesmosomes • Activation of complement

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