ch 17 rbc morphology
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CH 17 – RBC Morphology

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CH 17 – RBC Morphology. Erythrocytes. >99% of the formed elements function to carry O 2 , CO 2 & H + anatomy biconcave disks, 8 µm in diameter no nucleus limited metabolic activity ~280 million hemoglobin (Hgb) molecules/cell O 2 carrying protein

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erythrocytes
Erythrocytes
  • >99% of the formed elements
  • function to carry O2, CO2 & H+
  • anatomy
    • biconcave disks, 8 µm in diameter
  • no nucleus
  • limited metabolic activity
  • ~280 million hemoglobin (Hgb) molecules/cell
    • O2 carrying protein
    • synthesized in cytosol before the nucleus is lost
    • 33% of cell weight
erythrocytes1
Erythrocytes
  • Bi-Concave disc shape
    • creates a higher surface area/volume ratio increases gas diffusion
    • very flexible structure allows passage through capillaries
    • the smallest capillaries are no wider than an RBC
erythrocytes2
Erythrocytes
  • Normal Hgb in blood
    • Infants: 14-20g Hgb/100ml
    • Adults:
      • Males: 14-15g Hgb /100ml
      • Females: 12-15g Hgb /100 ml
hemoglobin structure
HemoglobinStructure
  • O2 combines with Hgb in lungs
    • O2 not very soluble in H2O
    • O2 needs a molecular transporter to carry it
  • Hemoglobin
    • 4 globin (protein) chains - 2 α chains & 2 β chains
    • 4 non-protein heme pigments (lipid)
    • each heme pigment has iron ion (Fe²+) that carries 1 O2
    • each RBC can carry about 1 billion O2 molecules
  • RBC\'s carry ~25% of the CO2 bound to Hgb - forms carbaminohemoglobin
erythrocyte rbc life span
Erythrocyte (RBC) Life Span
  • Life span
    • only 100-120 days
    • cannot repair damage due to loss of nucleus, ribosomes
  • Old RBC’s destroyed in the spleen, liver and the bone marrow
    • Macrophages phagocytize old worn RBC\'s
    • Breakdown products are recycled
    • Different pathways exist for each part of the Hgb molecule
      • globin chains - AA\'s used for other protein synthesis
      • heme
        • iron portion - Fe2+ recycled
        • non-iron lipid portion – converted to bilirubin - waste
          • released into blood, secreted by the liver into bile
          • bile enters intestine, is converted to urobilinogen by bacteria
          • contributes to urine & feces color
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RBC Morphology

CH 17

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