Ch 17 rbc morphology
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CH 17 – RBC Morphology. Erythrocytes. >99% of the formed elements function to carry O 2 , CO 2 & H + anatomy biconcave disks, 8 µm in diameter no nucleus limited metabolic activity ~280 million hemoglobin (Hgb) molecules/cell O 2 carrying protein

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Erythrocytes
Erythrocytes

  • >99% of the formed elements

  • function to carry O2, CO2 & H+

  • anatomy

    • biconcave disks, 8 µm in diameter

  • no nucleus

  • limited metabolic activity

  • ~280 million hemoglobin (Hgb) molecules/cell

    • O2 carrying protein

    • synthesized in cytosol before the nucleus is lost

    • 33% of cell weight


Erythrocytes1
Erythrocytes

  • Bi-Concave disc shape

    • creates a higher surface area/volume ratio increases gas diffusion

    • very flexible structure allows passage through capillaries

    • the smallest capillaries are no wider than an RBC


Erythrocytes2
Erythrocytes

  • Normal Hgb in blood

    • Infants: 14-20g Hgb/100ml

    • Adults:

      • Males: 14-15g Hgb /100ml

      • Females: 12-15g Hgb /100 ml


Rbc s electron microscopy
RBC’s (Electron Microscopy)

electron microscopy


Hemoglobin structure
HemoglobinStructure

  • O2 combines with Hgb in lungs

    • O2 not very soluble in H2O

    • O2 needs a molecular transporter to carry it

  • Hemoglobin

    • 4 globin (protein) chains - 2 α chains & 2 β chains

    • 4 non-protein heme pigments (lipid)

    • each heme pigment has iron ion (Fe²+) that carries 1 O2

    • each RBC can carry about 1 billion O2 molecules

  • RBC's carry ~25% of the CO2 bound to Hgb - forms carbaminohemoglobin


Erythrocyte rbc life span
Erythrocyte (RBC) Life Span

  • Life span

    • only 100-120 days

    • cannot repair damage due to loss of nucleus, ribosomes

  • Old RBC’s destroyed in the spleen, liver and the bone marrow

    • Macrophages phagocytize old worn RBC's

    • Breakdown products are recycled

    • Different pathways exist for each part of the Hgb molecule

      • globin chains - AA's used for other protein synthesis

      • heme

        • iron portion - Fe2+ recycled

        • non-iron lipid portion – converted to bilirubin - waste

          • released into blood, secreted by the liver into bile

          • bile enters intestine, is converted to urobilinogen by bacteria

          • contributes to urine & feces color



End

RBC Morphology

CH 17


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