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Regional Higher Education Conference 3-5 Dec, 2007 . Country case: Malaysia Issues on Research, Development and Commercialization. Prof Asma Ismail, Director, Institute for Research in Molecular Medicine (INFORMM), Health Campus,USM, 16150 Kubang Kerian, Kelantan and

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country case malaysia issues on research development and commercialization

Regional Higher Education Conference

3-5 Dec, 2007

Country case: MalaysiaIssues on Research, Development and Commercialization

Prof Asma Ismail,

Director,

Institute for Research in Molecular Medicine (INFORMM),

Health Campus,USM, 16150 Kubang Kerian, Kelantan and

Suite 110, Eureka Complex, USM

Minden, Penang

slide2

The Global agenda

© DAR2003

Knowledge era

Biotechnology era

The need

to move to K-economy

IT era

Increasing competition

Technological era

Agricultural era

Hot

Spots

21st

century

(Future)

Primitive era

650

1750

1950

2000

Modified from Richard W Oliver, The shape of things to come

stages of economy for malaysia
Stages of economy for Malaysia

From resource-driven to Innovation-driven

  • “As nation develop, they progress through a number of stages in terms of their characteristic competitive advantages and modes of competing”

Investment

-driven

economy

Innovation

-driven

economy

Resouce

-driven

economy

Knowledge-based

Rubber, palm oil etc

Multinationals at free trade zones

  • - Porter M, Enhancing the microeconomic foundations of prosperity

© DAR 2002

new r d challenges
New R&D challenges
  • Challenge for R&D in the country would be how to move towards the requirements needed to succeed in the Innovation-led economy:
  • Technology-driven (10-15 years)
    • Dependent on our researchers
      • Own original scientific discoveries that will enhance the competitiveness and provides the leading edge for the country.
      • Set new trends in technology and create our own technology platforms
      • Ability to combine scientific discoveries and technology platforms to create new innovations that can create an impact to society and the global market; undergo translational research
  • Market-driven (3-5 years)
    • Dependent on our business community/government
    • Dependent on funding
    • Buy existing technology and innovate
  • Innovation-led economy
  • Technology driven
  • Market driven
challenges in innovation led economy that affects r d
Challenges in Innovation-led economy that affects R&D
  • Political will
    • Create policies that support R&D, innovation and entrepreneurship
  • Human capital
    • Sufficient number of innovative, creative and relevant human capital (Knowledge-workers)
    • Originality and IP
      • Must show originality and creativity in offering solutions to problems with the generation of intellectual properties/ patents
    • Change in the R&D approach
      • Harness the human capital to create an environment of innovative culture
      • Work with the end in mind
  • Funding
    • Funding to drive R-D-C-E
    • Funding to buy existing technology (market-driven)
r d being the national agenda

‘Being a global player is unavoidable for a country that wants to develop’

- Abdullah

POLITICAL WILL

R&D being the National Agenda
  • Malaysia has the political will to ensure that R&D is the national agenda to drive the K-economy of the country (O.5% of GDP (6%).
  • The government has provided a lot of national grants (at least RM 1.7 billion from 2006-2010) to promote R&D&C
  • But is the amount ENOUGH to promote commercialization of research products
slide7

Moving towards successful K-economy:

R&D Challenge

PHASE 1

Making

scientific discoveries

Phase 1: Consolidating Research

R

Research discoveries, acquisition of technologies

Applied and fundamental grants

D

PHASE 2

Develop

prototype

Phase 2: Consolidating Development

  • Design, engineering and technology integration

Development grants, pre-bridging grants

C

Phase 3: Consolidating Commercialization

Patent, Marketing, Entrepreneurship and licensing

PHASE 3

Commercialize

Techno fund

Phase 4: Consolidating Knowledge-based enterprise (Research Park)

E

Smooth and continuous flow of R-D-C-E

PHASE 4

K-enterprise

  • Spin off companies/ JV companies

Venture Capitalists, Innofund

slide8

Pitfalls and challenges:

Status of Research & Development in Malaysia

R

Phase 1: Consolidating Research

Need to improve the number of publications

Need to improve impact factor

Need to improve citations

D

Phase 2: Consolidating Development

Phase 3: Consolidating Commercialization/Innovation/Technology licencing

C

WHY are we

not there yet?

  • Commercial arm of the University
  • Entrepreneurship
  • Spin-off companies
  • JV Companies
  • Licensing

E ???????

why are we not there yet human capital
WHY are we not there yet?Human capital

Not sufficient K -workers!

Need 60/10,000 pop

National Survey of Research and Development 2004, MASTIC

expectations of modern universities in the knowledge era
Expectations of Modern Universities in the Knowledge-era
  • Role of Universities include the need to train the human capital to be relevant and support the innovative culture
  • Expectations of Modern Universities
    • Generate knowledge
    • Disseminate knowledge
    • Facilitate translation of knowledge into tangible and intangible products
  • Universities are expected to undergo Research-Development-Commercialization of R&D and setting up of Knowledge-based enterprises in the Research Park
  • In Malaysia, we now have Research Universities that should lead the way to generate IP and wealth for the country and enhance the quality of life of the people.
slide11

If patents indicate originality/creativity

Indigenous Technology

We lacked originality in

performing R&D

Fadzilah Ahmad Din. National S&T Indicators in Malaysia: Where are we now?.

MASTIC, MOSTE, National Symposium on S&T, July 28-30,2003.

We lacked efficiency in

producing patents

slide12

Patents

  • Are people aware about IPR?
  • We need to encourage IPR awareness and the patent culture.
  • We should not view patents as a number game.
  • When we patent we should use it to design and develop new innovations. Patents must be used to generate income. It is used to generate K-based industries for the country.

The iceberg phenomenon

commercialization of research products
Commercialization of research products
  • Commercialization of R&D products is not a simple process
  • It is a complex exercise that must address several issues before we can take the technology/product/process to the market
slide14

Commercialization of Knowledge

Idea (scientific discovery)

+

Innovative Technology

  • Undergo translational Research
  • Research theses
  • Patents and IPRs
  • Commercial viability
  • Business plan
  • Win awards

UNIVERSITY’s

ROLE

Lab model

Evaluate (lab-level)

DISCOVERY

COMPANY’s

ROLE

Issues: Since

industry

not ready, univ

has to do

both roles

Prototype

  • Business plan
  • Win awards

Packaging

Product

DEVELOPMENT AND INNOVATION

Evaluation

(multi-centres)

Technology

Licencing

Courtesy of Sam Teng Wah, USAINS

slide15

Benchmark with UK

2004 UK Patent-Investment ratios for 11 sectors

http://www.innovation.gov.uk/rd_scoreboard/patents_ratio.asp

No of disclosures differ

For different areas of focus

Ave 2.8 million pounds/patent

RM 20 million/patent

Investment of RM 1760 million, Malaysia should have 88 patents

But only 25 patents in biotech

Most expensive!

reality check patent vs licencing
Reality check: Patent vs licencing
  • In USA the ratio of commercialization to patent is 1:3.5
  • Since we are spending RM1,760 we should hypothetically produced 88 patents ( 25 technology licencing for the country or 7 biotech licencing for the country)
  • Hence the lack of technology licencing and the setting up of K-based industries due to insufficient funding.
reality check financial investment
Reality check: Financial investment
  • Business community:
    • Must believe that knowledge can be turned into a business
    • Must have strong network of angel investors
    • Must perform research as the basic building block for any K-based industry
reality check financial investment1
Reality check: Financial investment
  • Currently Malaysian business communities lack the knack for K-based industries. Majority are still into property and manufacturing.
  • They will only come in at the latter part of research when you have developed
    • a product or devise or services or a process to undergo technology licensing or direct selling
  • Venture Capitalists as investors are also not adventurous (does not take risks).
reality check need to change paradigm to do research
Reality check: Need to change paradigm to do research
  • We must meet the industry half way.
  • We must understand that in the new economy, a discovery has no value until it can benefit the public. Publishing and winning gold medals for the products created are not enough. It has to be commercialised.
  • Compromise: Work with the end in mind.
      • Cater for the needs of the client.
      • R&D product would be more commercially viable
  • Experimental design strategy must be from Z to A rather than A to Z.
paradigm shift the new research approach
Paradigm shift: The New Research approach
  • Strike a balance between fundamental and applied in order to undergo
  • Translational Research (Move R to D to C)
  • Work in multi-disciplinary clusters

Generate

new industries

Produce relevant

scientists and

postgraduates to

be drivers of K-economy

  • Generate Patents
  • Publications

Create new

Scientific

discoveries

Enhance

quality

of life

INNOVATIONS

STRATEGIC

FUNDAMENTAL

RESEARCH

Z

A

+

Work with end in mind

Check market/client requirements

Develop

Advances in

Technology

  • Incentives for scientists
  • Incentives for industries

Consolidate

existing

industries

Z

To ensure products remain technologically competitive

the innovation system at usm
The Innovation system at USM

R

  • Research
  • Development
  • Commercialisation
  • Enterprises (knowledge-based)
  • ResearchPark

(in-campus ‘industrial alliances’)

D

C

E

(P)

Innovation

-driven

Global vs Local

© DAR2003

slide23

Working from Z to A (end in mind): Market foresight requirements for rapid diagnostics

Criteria for Design and development

  • Rapid
  • Specific
  • Sensitive
  • Easy to perform
  • Cost effective
  • Can be transported without cold chain
  • Dot EIA
  • Dipstick
  • Sensor technology
  • Thermostabilised PCR
  • PCR DNA chip

Scientific

discovery

Technology

platform

Patent separately

slide24

Contribution to K-economy: Molecular Diagnostics

Rapid protein or DNA - based diagnostics for the following diseases

  • Typhoid
  • Cholera
  • Campylobacteriosis
  • Filariasis
  • Tuberculosis
  • Dysentery
  • Paratyphoid
  • Nosocomial infections
  • Pharmacogenomics (Drug response to TB)

Focus on diseases relevant to S.E Asia

slide25

ORIGINAL

DISCOVERIES

Commercialization Track record: Antibody-based Biotech kits

6 kits commercialised

2002

1996

2005

1994

Bancroftian filariasis -2005

Pan filariasis -2006

planned strategic approach for creation of technology platforms road map for typhoid diagnosis
Planned strategic approach for creation of technology platforms( Road map for typhoid diagnosis )

Thermostabilised PCR

Universal PCR Chip

(Nanotechnology)

Immuno-chromatography

Dot EIA

(Require cold chain)

(No cold chain)

Scientific Discovery 50kDa

1986-1991

EZTYPHI carrier DNA

TYPHIrapid™

15 min

1998

2007

2005

2004

1997

1994

TYPHOID DIAGNOSIS

slide27

Commercialization of TYPHIDOT – a rapid

diagnostic test for typhoid

R&D is necessary to

make the product

technologically

competitive

Pakistan

India

Philippines

South Africa

Guam

Papua New Guinea

Thailand

Vietnam

Egypt

Turkey

United Arab Republic

Indonesia

Bangladesh

China

Sudan

Cameroon

Nigeria

USA

  • Outputs
  • 33Publications
  • 7 Patents
  • Creation of 500 jobs
  • Supported local industries
  • Generated income
  • Won >50 awards

Global Distribution of Typhoid Fever

slide28

Create new technology platforms for molecular diagnostics

Thermostabilised PCR

USM invention

M. Ravichandran et al

Boil sample

to obtain DNA

3 min

40 min

80 min

100bp DNA ladder marker

Sample DNA + water

(2 steps)

Add 2 ul lysate

+ 18 ul water

PCR product 415bp

Amplication of target genes

  • No cold storage
  • Only two pipetting steps
  • Does not need PCR skilled personnels
  • Cheap (USD 10 to now USD 1)

Gel electrophoresis analysis

Duration: Approx 2.5 to 3 hours

Require

collaboration of strengths

slide29

Thermostabilised PCR kits

2003 2004 2005 2006 2007

EZEBV Amp

ITEX 2004 Gold medal

WIPO Gold Medal

KASS Award 2004

Geneva 2005 Gold Medal

EZDysentry DNA

ITEX 2005 Silver Medal

EZVRE Amp

ITEX 2005 Gold medal

Geneva 2006 Gold Medal

EZCholera Amp

ITEX 2003 Silver Medal

Cholera Genosensor

A total solution

SOLD

EZCampy DNA

Expo S&T 2005 Silver Medal

Geneva 2006 Silver Medal

EZTyphi Carrier DNA

ITEX 2005 Gold medal

ITEX 2005 Best Invention in Biotechnology

Geneva 2006 Silver Medal

EZDNA Amp

Expo S&T 2003 Silver medal

Commercialized by MBDr

M’sian Patent: PI 20051471

EZAmp Octaplex Cholera

ITEX 2004 Gold medal

WIPO Gold Medal

Geneva 2005 Gold Medal

SOLD

EZTB Amp

ITEX 2004 Silver medal

Commercialized by MBDr

Courtesy: M Ravichandran, USM

slide30

Conclusion

  • Development of technologically competitive product/device/process/expertise is no longer a luxury.
  • It is a necessity
  • It would require collaboration with other strengths on a global scale to stay ahead of the game
  • Malaysian R&D must be relevant, accessible, bring in respect and profits and not an economic drain

ICT quad scan

Universal

PCR chip

Genosensor

acknowledgements
Acknowledgements
  • Committee for National Strategies for Biotechnolgy
  • Committee for Human capital development – ASM
  • Committee for Strategic plans for KPT on R-D-C Issues
slide32

ISO 9001:2000

certified

UK, France,

Malaysia, Italy,

Germany

THANK YOU

INFORMM Health campus

INFORMM Main campus

[email protected]

Http: www.informm.usm.my

Institute for Research in Molecular Medicine

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