Perturbações do metabolismo e desdiferenciação celular no cancro
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Perturbações do metabolismo e desdiferenciação celular no cancro. Cancer Biology Valdemar Máximo. Efeito de Warburg. Glicólise OXPHOS Mesmo na presença de O 2. Adaptado de Vander Heiden MG et al. Science (2009). Efeito de Pasteur Efeito de Warburg.

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Perturbações do metabolismo e desdiferenciação celular no cancro.

Cancer Biology

Valdemar Máximo


Efeito de no cancroWarburg

  • Glicólise

  • OXPHOS Mesmo na presença de O2


Adaptado de no cancroVander Heiden MG et al. Science (2009)


Efeito de no cancroPasteur Efeito de Warburg

Nâo-fixo Fixo

Adaptado de Vander Heiden MG et al. Science (2009)


Adaptado de no cancroDeBerardinis RJ et al. Genet Med. (2008)


OXPHOS no cancro




Br J Cancer no cancro, 2005

  • nDNA (GRIM-19)


Transfection control no cancro

Transfection control

siRNA control

siRNA control

Cell control

GRIM II

Cell control

GRIM II

GRIM-19 SiRNA

GRIM-19

Hk2

GLUT1

Actin

24 hours

48 hours


  • Mitotracker/Actin

siRNA control

(200nM)

GRIM II

(200nM)

siRNA control

(200nM)

GRIM II

(200nM)

24 hours

48 hours

  • Morfologia

GRIM II

(200nM)


Conclusão no cancro

OXPHOS

OXPHOS

Adaptado de DeBerardinis RJ et al. Genet Med. (2008)


Agradecimentos no cancro

Grupo Cancer Biology

Jorge Lima

Paula Soares

Manuel Sobrinho-Simões


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