Perturbações do metabolismo e desdiferenciação celular no cancro
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Perturbações do metabolismo e desdiferenciação celular no cancro. Cancer Biology Valdemar Máximo. Efeito de Warburg. Glicólise OXPHOS Mesmo na presença de O 2. Adaptado de Vander Heiden MG et al. Science (2009). Efeito de Pasteur Efeito de Warburg.

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Cancer biology valdemar m ximo

Perturbações do metabolismo e desdiferenciação celular no cancro.

Cancer Biology

Valdemar Máximo


Cancer biology valdemar m ximo

Efeito de Warburg

  • Glicólise

  • OXPHOSMesmo na presença de O2


Cancer biology valdemar m ximo

Adaptado de Vander Heiden MG et al. Science (2009)


Cancer biology valdemar m ximo

Efeito de Pasteur Efeito de Warburg

Nâo-fixo Fixo

Adaptado de Vander Heiden MG et al. Science (2009)


Cancer biology valdemar m ximo

Adaptado de DeBerardinis RJ et al. Genet Med. (2008)


Cancer biology valdemar m ximo

OXPHOS


Cancer biology valdemar m ximo

  • mtDNA


Cancer biology valdemar m ximo

  • nDNA (SDHx)


Cancer biology valdemar m ximo

Br J Cancer, 2005

  • nDNA (GRIM-19)


Cancer biology valdemar m ximo

Transfection control

Transfection control

siRNA control

siRNA control

Cell control

GRIM II

Cell control

GRIM II

GRIM-19 SiRNA

GRIM-19

Hk2

GLUT1

Actin

24 hours

48 hours


Cancer biology valdemar m ximo

  • Mitotracker/Tubulin

  • Mitotracker/Actin

siRNA control

(200nM)

GRIM II

(200nM)

siRNA control

(200nM)

GRIM II

(200nM)

24 hours

48 hours

  • Morfologia

GRIM II

(200nM)


Cancer biology valdemar m ximo

Conclusão

OXPHOS

OXPHOS

Adaptado de DeBerardinis RJ et al. Genet Med. (2008)


Cancer biology valdemar m ximo

Agradecimentos

Grupo Cancer Biology

Jorge Lima

Paula Soares

Manuel Sobrinho-Simões


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