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OMICS OF PROTEIN BOUND UREMIC SOLUTES

OMICS OF PROTEIN BOUND UREMIC SOLUTES. R Vanholder University Hospital, Gent, Belgium. UNTARGETED METABOLOMICS. DETECTION OF UNKNOWN TOXINS BY TARGETED APPROACH. Boelaert et al, Metabolomics , doi 10.1007/s11306-013-0592-s. DETECTION OF UNKNOWN TOXINS BY TARGETED APPROACH.

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OMICS OF PROTEIN BOUND UREMIC SOLUTES

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  1. OMICS OF PROTEIN BOUND UREMIC SOLUTES R Vanholder University Hospital, Gent, Belgium

  2. UNTARGETED METABOLOMICS

  3. DETECTION OF UNKNOWN TOXINS BY TARGETED APPROACH Boelaert et al, Metabolomics, doi 10.1007/s11306-013-0592-s

  4. DETECTION OF UNKNOWN TOXINS BY TARGETED APPROACH Boelaert et al, Metabolomics, doi 10.1007/s11306-013-0592-s

  5. METABOLOMICS TO DETECT VOLATILE TOXINS Pagonas et al, PlosOne, 7:e46258; 2012

  6. METABOLOME AND PROGRESSION OF CKD

  7. URINARY METABOLOMIC MARKERS OF PROGRESSION FROM NORMO-ALBUMINURIA van der Kloet et al, Metabolomics, 8: 109-119; 2012

  8. URINARY METABOLOMIC MARKERS OF PROGRESSION FROM NORMO-ALBUMINURIA van der Kloet et al, Metabolomics, 8: 109-119; 2012

  9. SOLUTES AFFECTED BY PROTECTIVE DRUGS

  10. MARKERS IN KIDNEY TISSUE OF RENAL INJURY AND RENAL PROTECTION IN RATS FLP= Fu-Ling-Pi Zhao et al, J Pharm Biomed Anal, 81-82:202-209; 2013

  11. MARKERS IN KIDNEY TISSUE OF RENAL INJURY AND RENAL PROTECTION IN RATS Zhao et al, J Pharm Biomed Anal, 81-82:202-209; 2013

  12. KIDNEY TISSUE MARKERS OF PROGRESSION AND FOSINOPRIL PROTECTION IN DIABETIC RATS Zhao et al, J Pharm Biomed Anal, 60: 32-43; 2012

  13. THE ROLE OF AST-120

  14. REMOVAL OF INDOXYLSULFATE BY AST-120 PROTECTS GLOMERULAR FILTRATION RATE 1.0 0.9 0.8 0.7 AST-120 eGFR, relative to baseline Control 0 8 16 24 32 40 48 56 Time (weeks) P<0.001 Akizawa T. et al, AJKD, 54:459-467; 2009

  15. AST-120 ABSORBS MORE THAN INDOXYL SULFATE ALONE IN RATS Kikuchi et al, J Chromatogr B, 878: 2997-3002; 2010

  16. AST-120 ABSORBS MORE THAN INDOXYL SULFATE ALONE IN RATS Kikuchi et al, J Chromatogr B, 878: 2997-3002; 2010

  17. AST-120 ABSORBS MORE THAN INDOXYL SULFATE ALONE IN RATS Kikuchi et al, J Chromatogr B, 878: 2997-3002; 2010

  18. AST-120 ABSORBS MORE THAN INDOXYL SULFATE ALONE IN RATS Akiyama et al, Toxins, 4: 1309-1322; 2012

  19. METABOLOMICS TO UNRAVEL THE ROLE OF THE INTESTINE IN UREMIC TOXIN GENERATION

  20. ROLE INTESTINE IN GENERATION CRESOLS p-cresol tyrosine intestinal flora intestinal wall p-cresylsulfate liver p-cresylglucuronide Schepers et al, BloodPurif, 29: 130-136; 2010

  21. PLASMA PROTEIN BOUND SOLUTES ARE DECREASED IN GERMFREE MICE Wikoff et al, PNAS, 106: 3698-3703; 2009

  22. PLASMA PROTEIN BOUND SOLUTES ARE DECREASED IN GERMFREE MICE Fig. 3. Sulfate profiling based on constant neutral loss scanning of 80 m/z in ESI mode for conv (Upper) and GF (Lower) pooled plasma samples. The m/z values for several species are listed above their respective peak. Identified sulfates include: phenyl sulfate (a), indoxyl sulfate (b), p-cresol sulfate (c), equol sulfate (d), and methyl equol sulfate (e). Wikoff et al, PNAS, 106: 3698-3703; 2009

  23. THE COLON CONTRIBUTES TO UREMIC TOXIN GENERATION Aronov et al, JASN, 22:1769-1776; 2011

  24. THE COLON CONTRIBUTES TO UREMIC TOXIN GENERATION Aronov et al, JASN, 22:1769-1776; 2011

  25. THE COLON CONTRIBUTES TO UREMIC TOXIN GENERATION Aronov et al, JASN, 22:1769-1776; 2011

  26. THE COLON CONTRIBUTES TO UREMIC TOXIN GENERATION Aronov et al, JASN, 22:1769-1776; 2011

  27. CHANGES IN ASSIMILATION MODIFY THE GENERATION OF P-CRESYLSUFATE Bammens et al, KI, 64: 2196-2203; 2003

  28. CHANGES IN ASSIMILATION MODIFY THE GENERATION OF P-CRESYLSUFATE Group A: GFR > 60 Group B: GFR 30-60 Group C: GFR < 30 (A) The median values of urinary p-cresol output (mg/24 hours) in the three study groups. (B) The median values of the urinary p-cresol (mg/24 hours)/urinary urea nitrogen (g/24 hours) ratio. *P < 0.05 vs. group A. Bammens et al, KI, 64: 2196-2203; 2003

  29. METABOLOMICS TO UNRAVEL THE ROLE OF TUBULAR PUMPS IN UREMIC TOXIN REMOVAL

  30. ORGANIC ANION TRANSPORTERS PUMP INDOXYL SULFATE INTO THE TUBULAR CELLS Deguchi et al, KI, 61: 1760-1768; 2002

  31. ORGANIC ANION TRANSPORTERS PUMP INDOXYL SULFATE INTO THE TUBULAR CELLS Time-course of [3H]indoxyl sulfate uptake by X. laevisoocytes injected with water or rOAT3 cRNA. The uptake of 2 mol/L [3H]indoxyl sulfate in water-injected oocytes () and rOAT3-expressing oocytes () were measured during a 120-minute incubation. Each bar represents the mean SEM (N = 10 to 12). Deguchi et al, KI, 61: 1760-1768; 2002

  32. METABOLOMICS FOR THE DETECTION OF SUBSTRATE FOR TUBULAR PUMPS Wikoff et al, J ProteomeRes, 2842-2851, 2011 Toyohara et al, JASN, 20:2546-2555; 2009

  33. METABOLOMICS FOR THE DETECTION OF SUBSTRATE FOR TUBULAR PUMPS Wikoff et al, J ProteomeRes, 10:2042-2051; 2011 Toyohara et al, JASN, 20:2546-2555; 2009

  34. CLEARANCE OF INTESTINALLY GENERATED TOXINS AND GFR DO NOT MATCH Suchey-Dicey, JASN, 27: 2148–2155; 2016

  35. CLEARANCE OF INTESTINALLY GENERATED TOXINS AND GFR DO NOT MATCH Suchey-Dicey, JASN, 27: 2148–2155; 2016

  36. NEWLY DETECTED POTENTIALLY CARDIO-TOXIC CULPRITS

  37. P-CRESYLSULFATE AND P-CRESYLGLUCURONIDE Martinez et al, JASN, 16: 3430-3436; 2005

  38. P-CRESYLSULFATE AND P-CRESYLGLUCURONIDE Martinez et al, JASN, 16: 3430-3436; 2005

  39. P-CRESYLSULFATE AND P-CRESYLGLUCURONIDE Meert et al, NDT, 27: 2388–2396; 2012

  40. P-CRESYLSULFATE AND P-CRESYLGLUCURONIDE Meert et al, NDT, 27: 2388–2396; 2012

  41. P-CRESYLSULFATE AND P-CRESYLGLUCURONIDE Meert et al, NDT, 27: 2388–2396; 2012

  42. INDOLE ACETIC ACID AFFECTS CARDIAC OUTCOMES AND ENDOTHELIAL FUNCTION Dou et al, JASN, doi: 10.1681/ASN.2013121283

  43. INDOLE ACETIC ACID AFFECTS CARDIAC OUTCOMES AND ENDOTHELIAL FUNCTION Dou et al, JASN, doi: 10.1681/ASN.2013121283

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