Fabio Carvalho , Linda C Carrijo-Carvalho , Ana Marisa Chudzinski-Tavassi, Annette Foronda, Denise de Freitas . Low-molecular weight proteins as potential virulence factors of Acanthamoeba pathogens in corneal infection.
Fabio Carvalho, Linda C Carrijo-Carvalho, Ana Marisa Chudzinski-Tavassi, Annette Foronda, Denise de Freitas
Low-molecular weight proteins as potential virulence factors of Acanthamoeba pathogensin corneal infection
Supported by grant from Brazilian Scientific Foundations: FAPESP (08/53969-0), CAPES, CNPq.
Corneal infections due to free-living amoebae have potentially devastating consequences. If not successfully treated, it can progress into the eye, causing corneal ulcer, loss of visual acuity and eventually blindness.
Proteases represent a class of enzymes which are related with pathogenicity and cytolysis of Acanthamoeba species and genotypes.
To evaluate the expression of extracellular proteins by Acanthamoeba trophozoites as predictive virulence factors in the corneal infection by the protozoa.
Lanes 3 and 6:
Lanes 11 and 12:
Low molecular weight protein
Collagenases should be suggested as a virulence marker in the differentiation of Acanthamoeba species and genotypes.