Inflammation. What is it? What are the stages, and occurrences in those stages? Extensions?. Human Biology. Inflammation. Attempt to restore homeostasis in an area. Injury…the inflammatory response is initiated. Protective, defensive. Inflammation. Etiologies: Mechanical Trauma
What is it?
What are the stages, and occurrences in those stages?
Inflammation due to gout
Damaged, absent, malformed vessels
Note: This is showing you an illustration of edema, and not the entire inflammatory response.
1) Vasodilation and increased permeability of blood vessels.
2) Phagocyte migration
3) Release of nutrients/Metabolic increase
Need more energy
To deal with this
Mechanically wounded epithelium forming
New junctions (arrow). (false color)
4) Fibrin Formation
5) Pus Formation
Patient was in hospital
for 5 weeks, receiving IV
antibiotics and surgery.
Doesn’t look too good.
Two weeks later, after maggots have been applied. See the healthy tissue? It is red and bloody, but healthy.
3 Months later…
An excellent result.
The scarring will fade
over the coming months.
Surgeons had a tough time figuring out which was good tissue and bad tissue, due to the advanced nature of the ulceration. They didn’t want to cut too much away.
3 years of foot ulcers in this 70 yr. old patient.
After maggots were applied, the wound was cleaned, and the dead tissue was removed. As you can tell, the maggots did a much better job than the surgeons could.
After healing, the wound looks fantastic.
Two years afterwards, the wound had not reoccurred.
Last 7 slides are from Maggot Therapy Project, University of California, Irvine.