MEASLES. RUBEOLA OR MORBILLI Department of infectious disease WANG JINGYAN. DEFINITION.
RUBEOLA OR MORBILLI
Department of infectious disease
it has been classed as a paramyxovirus.it is spherical in appearance ,measuring about 100~150nm in diameter.It has an outer envelope composed of M-protein, H-protein, F-protein, and internal core is RNA.
measles can be detected from blood and nasal, pharyngeal secretions.
The patients are the only source of infection.
3.1 All age person is susceptible; 90% of contact people acquire the disease.
3.2 The permanent immunity acquire after disease.
season:winter and spiring
age:6 months to 5 years old
blood (first virusemia)
blood (second virusemia)
general toxic symptoms
2 .1 Fever;
2 .2 Catarrhal inflammation of URT;
2 .3 Koplik’s spots;
2 .4 Transient prodromal rashes.
3 .1. Time: the3~5 days after fever;but the 4th day is most common;
3 .2 . Shape:maculopapular
3.3. Seuence:behind the ear→along the hairline→face→neck→chest→back→abdomen→limbs→hand and feet(palm,sole)
3 .4 . The temperature rise continously and companied with the toxic symptoms exaggerate
fine branny desquamation.
1 . mild measles;
2 . severe measles (toxic and shock type measles);
3. hemorrhagic measles;
4 . variant measles.
Encephalitis and SSPE .
viral encephalitis retrograde change
late crossed immune
complement combining antibody;
hemagglutinin inhibiting antibody;
specific antibody IgM.
*the early stage definite diagnosis is:
*the early stage clinical diagnosis is:
*the clinical diagnosis is:
traditional chinese herbs may be used ;
3.1 . Active immunization
Lived attenuated measles vaccine.
epidemic stage:before 2 m
contactor:with in 2 days
Contraindications:pregnancy et al
3.2 . Passive immunization
placenta globulin or gamma globulin.
<5 days prevent onset
>5 days relieve symptoms