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1.0. 0.8. 0.6. Sensitivity. 0.4. 0.2. 0.0. 0.0. 0.2. 0.4. 0.6. 0.8. 1.0. 1 - Specificity. ACRIN – Ten Excellent Years. ACRIN RA Sessions-2009. ACRIN Past and Future. Origins of ACRIN ACRIN’s initial organization Structure People Accomplishments The Future.

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Acrin ten excellent years

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ACRIN – Ten Excellent Years

ACRIN RA Sessions-2009


Acrin past and future
ACRIN Past and Future

  • Origins of ACRIN

  • ACRIN’s initial organization

    • Structure

    • People

  • Accomplishments

  • The Future


Acrin the beginning
ACRIN: The Beginning

  • 1997 – Dr. Robert Wittes convenes

  • two meetings to discuss the

  • “feasibility” of multi-center trials of

  • imaging

    • Growing importance of imaging to cancer care

    • Imaging as a marker of treatment response

    • Imaging to describe cancer biology


Acrin the beginning1
ACRIN: The Beginning

  • 1997 – Inception of NCI DIP

    (later BIP, now CIP)

  • Early 1998 – Issuance of

    RFA for a clinical trials

    “network” for imaging as it

    relates to cancer

    • Linked HQ and BC grants

    • Avoid the bureaucracy of established groups

    • Non-member


Acrin the beginning2
ACRIN: The Beginning

  • 1998 – ACR asked that I apply on behalf of ACR

    • Recruit C. Gatsonis

    • C. Olson as support staff

    • Organization of individuals

      and sites

  • Sept. 1998 – RFA awarded to ACRIN

  • Sept. 1998-March 1999 – Development of early infrastructure

    • Staff

    • Electronic communications

    • Bylaws and procedures


Acrin s mission
ACRIN’s Mission

Conduct clinical trials of imaging technologies to improve the length and quality of the lives of cancer patients.




Early acrin needs
Early ACRIN Needs

  • What we had:

    • Passion about our mission

    • Good science

    • Growing interest from sites and researchers

  • What we needed:

    • Quality management

    • Fiscal planning and direction

    • Improved reliability

    • Advocacy


If you try some time,

You might find

You get what you need.

- The Rolling Stones



Acrin accomplishments
ACRIN Accomplishments

  • 30 multi-center trials including signal trials that have changed cancer surveillance and care

    • High profile imaging screening trials

    • Trials of all applications of imaging

Diagnosis

Staging

Screening

Treatment

Response

Marker


Acrin accomplishments1
ACRIN Accomplishments

  • A network of more than 200 qualified sites

  • Hundreds of researchers

    • Radiologists and other clinicians

    • Site RAs

    • Statisticians and methodologists

    • Patient advocates

    • ACR staff


Acrin accomplishments2
ACRIN Accomplishments

  • Cadre of research associates to improve research in radiology departments

    • Active in all ACRIN activities

    • Education and training programs

    • Enhanced effectiveness for radiology research in the future



Acrin accomplishments3
ACRIN Accomplishments

  • Patient Advocate Committee - advocacy participation and community outreach for imaging trials

    • Project IMPACT

    • Participation in all ACRIN trials and committees

    • Educate key decision makers of the importance

      of imaging to research and care



Well trained clinical researchers
Well-Trained Clinical Researchers

  • “Laboratory” for research training and accomplishment

    • Further development of established researchers

    • Exposure and training for new clinical researchers


Acrin accomplishments4
ACRIN Accomplishments

  • All electronic network with infrastructure, policies, and procedures

  • Data archive for secondary research and new product development

  • Dissemination of standards for conducting imaging trials

  • Improved awareness of the importance of imaging to cancer research and care


Acrin accomplishments5
ACRIN Accomplishments

Treatment Cooperative Groups

Industry/

Foundations

Patient Advocate

Groups

ACRIN

Academia

Government

SPOREs

Cancer Centers

Community Hospitals and Clinics


The future
The Future

  • 1999-2003: Target of opportunity

  • 2004-2007: Objective-driven

  • 2008-2013: Greater sophistication

    • Consistent with the progression toward

      molecular medicine and individualized

      cancer care

      • Targeted surveillance of at-risk populations

      • Characterization of cancer to drive targeted

        therapies

      • Predictive and prognostic biomarkers of

        cancer treatment


Acrin diversification
ACRIN Diversification

  • Achieve funding that allows for trials other than cancer – CV and CNS to start

    • ACRIN Fund for Innovative Imaging to diversify outside of cancer

      • Springboard to other funding

        • NHLBI

        • NINDS

    • ACR Image Metrix profits

    • PA-CURE and foundations


When a blind beetle

crawls over the

surface of a

curved branch,

it doesn’t notice

that the track it has

covered is indeed

curved. - Albert Einstein


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