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1.0. 0.8. 0.6. Sensitivity. 0.4. 0.2. 0.0. 0.0. 0.2. 0.4. 0.6. 0.8. 1.0. 1 - Specificity. ACRIN – Ten Excellent Years. ACRIN RA Sessions-2009. ACRIN Past and Future. Origins of ACRIN ACRIN’s initial organization Structure People Accomplishments The Future.

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ACRIN – Ten Excellent Years

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1.0

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1 - Specificity

ACRIN – Ten Excellent Years

ACRIN RA Sessions-2009


ACRIN Past and Future

  • Origins of ACRIN

  • ACRIN’s initial organization

    • Structure

    • People

  • Accomplishments

  • The Future


ACRIN: The Beginning

  • 1997 – Dr. Robert Wittes convenes

  • two meetings to discuss the

  • “feasibility” of multi-center trials of

  • imaging

    • Growing importance of imaging to cancer care

    • Imaging as a marker of treatment response

    • Imaging to describe cancer biology


ACRIN: The Beginning

  • 1997 – Inception of NCI DIP

    (later BIP, now CIP)

  • Early 1998 – Issuance of

    RFA for a clinical trials

    “network” for imaging as it

    relates to cancer

    • Linked HQ and BC grants

    • Avoid the bureaucracy of established groups

    • Non-member


ACRIN: The Beginning

  • 1998 – ACR asked that I apply on behalf of ACR

    • Recruit C. Gatsonis

    • C. Olson as support staff

    • Organization of individuals

      and sites

  • Sept. 1998 – RFA awarded to ACRIN

  • Sept. 1998-March 1999 – Development of early infrastructure

    • Staff

    • Electronic communications

    • Bylaws and procedures


ACRIN’s Mission

Conduct clinical trials of imaging technologies to improve the length and quality of the lives of cancer patients.


ACRIN in the Beginning


ACRIN in the Beginning


Early ACRIN Needs

  • What we had:

    • Passion about our mission

    • Good science

    • Growing interest from sites and researchers

  • What we needed:

    • Quality management

    • Fiscal planning and direction

    • Improved reliability

    • Advocacy


If you try some time,

You might find

You get what you need.

- The Rolling Stones


What We Needed


ACRIN Accomplishments

  • 30 multi-center trials including signal trials that have changed cancer surveillance and care

    • High profile imaging screening trials

    • Trials of all applications of imaging

Diagnosis

Staging

Screening

Treatment

Response

Marker


ACRIN Accomplishments

  • A network of more than 200 qualified sites

  • Hundreds of researchers

    • Radiologists and other clinicians

    • Site RAs

    • Statisticians and methodologists

    • Patient advocates

    • ACR staff


ACRIN Accomplishments

  • Cadre of research associates to improve research in radiology departments

    • Active in all ACRIN activities

    • Education and training programs

    • Enhanced effectiveness for radiology research in the future


Research Associates


ACRIN Accomplishments

  • Patient Advocate Committee - advocacy participation and community outreach for imaging trials

    • Project IMPACT

    • Participation in all ACRIN trials and committees

    • Educate key decision makers of the importance

      of imaging to research and care


Patient Advocates


Well-Trained Clinical Researchers

  • “Laboratory” for research training and accomplishment

    • Further development of established researchers

    • Exposure and training for new clinical researchers


ACRIN Accomplishments

  • All electronic network with infrastructure, policies, and procedures

  • Data archive for secondary research and new product development

  • Dissemination of standards for conducting imaging trials

  • Improved awareness of the importance of imaging to cancer research and care


ACRIN Accomplishments

Treatment Cooperative Groups

Industry/

Foundations

Patient Advocate

Groups

ACRIN

Academia

Government

SPOREs

Cancer Centers

Community Hospitals and Clinics


The Future

  • 1999-2003: Target of opportunity

  • 2004-2007: Objective-driven

  • 2008-2013: Greater sophistication

    • Consistent with the progression toward

      molecular medicine and individualized

      cancer care

      • Targeted surveillance of at-risk populations

      • Characterization of cancer to drive targeted

        therapies

      • Predictive and prognostic biomarkers of

        cancer treatment


ACRIN Diversification

  • Achieve funding that allows for trials other than cancer – CV and CNS to start

    • ACRIN Fund for Innovative Imaging to diversify outside of cancer

      • Springboard to other funding

        • NHLBI

        • NINDS

    • ACR Image Metrix profits

    • PA-CURE and foundations


When a blind beetle

crawls over the

surface of a

curved branch,

it doesn’t notice

that the track it has

covered is indeed

curved.- Albert Einstein


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