Beh et s disease a case of peripheral ulcerative keratitis leading to corneal perforation
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Behçet’s Disease: A Case of Peripheral Ulcerative Keratitis Leading to Corneal Perforation PowerPoint PPT Presentation


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Behçet’s Disease: A Case of Peripheral Ulcerative Keratitis Leading to Corneal Perforation. Selcuk Sizmaz, Aysel Pelit, Meltem Yagmur, Didem Arslan, Yonca Aydin Akova. None of the authors have any financial or proprietary interest in any material used in the study. A 27 year-old man

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Behçet’s Disease: A Case of Peripheral Ulcerative Keratitis Leading to Corneal Perforation

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Behçet’s Disease: A Case of Peripheral Ulcerative Keratitis Leading to Corneal Perforation

Selcuk Sizmaz, Aysel Pelit, Meltem Yagmur, Didem Arslan, Yonca Aydin Akova

None of the authors have any financial or proprietary interest in any material used in the study


  • A 27 year-old man

  • Two day history of redness in the right eye

  • Corneal thinning involving the anterior stroma and adjacent conjunctival hyperemia, in the corneal limbus, at the 2- to 3-o’clock quadrant

  • No sign of dry eye

  • Topical ofloxacin and artificial tears prescribed


  • Three days later, signs worsened

    • Thinning involved the posterior stroma

    • Patient declined surgery


  • Two days later

    • Corneal perforation

    • İris prolapsed


  • Corneal patch graft and amniotic membrane transplantation


Ophthalmic and systemic evaluation

  • No significant ocular history

  • Oral aphthous lesions that had occurred once or twice a month for the previous 2 years

  • Eight years history of lower back and buttock pain with morning stiffness for 30 minutes

  • Arthralgia in the knee joints without swelling


  • Arterial BP (mmHg)

    • 130/80 right arm

    • 100/70 left arm

  • Weak pulse in left arm

  • Colour Doppler USG: left subclavian artery narrowing

  • MR angipgraphy: 4 cm-long diffuse stenosis in left subclavian artery

  • Sacroiliac graphy: grade II-III sacroiliitis

  • Pathergy test: (-)


Diagnosis: Behçet’s disease

  • Oral aphthous lesions

  • Ocular involvement

  • Large vessel vasculitis

  • Sacroiliitis


  • Management:

    • Methylprednisolone, 32 mg/day, po; tapered

    • Azathioprine, 150 mg/day, po

  • Prognosis (1 year follow-up):

    • No recurrence

    • Systemic symptoms improved


Differential diagnosis

  • Takayasu arteritis

    • Aorta and branches involved

    • No aphthous lesions

    • Sacroiliitis uncommon

    • Ocular invovement rare

  • Polyarteritis nodosa

    • Peripheral ulcerative keratitis occurs

    • Predominantly females

    • Aneurisms in small-middle sized vessels

    • Constitutional symptoms


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