Motor systems
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MOTOR SYSTEMS. Muscles and Joints Muscles Moving The Spinal Cord Spinal Reflexes Reciprocal Control of Opposing Muscles Polysynaptic Adaptations and Reflexes The Motor Cortex The Basal Ganglia Limbic System The Cerebellum Cranial Nerves.

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MOTOR SYSTEMS

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Motor systems

MOTOR SYSTEMS

  • Muscles and Joints

  • Muscles

  • Moving

  • The Spinal Cord

  • Spinal Reflexes

  • Reciprocal Control of Opposing Muscles

  • Polysynaptic Adaptations and Reflexes

  • The Motor Cortex

  • The Basal Ganglia

  • Limbic System

  • The Cerebellum

  • Cranial Nerves


Muscle groups are complex attach bone to bone via tendons and ligaments

Muscle groups are complex; attach bone to bone via tendons and ligaments


A muscle group has many fibers

A muscle group has many fibers


The neuromuscular junction nmj the receptive portion of muscle the motor end plate

The Neuromuscular junction (NMJ): The receptive portion of muscle-the motor end-plate


The nmj sometimes called the motor end plate

The NMJ ( sometimes called the motor end-plate)


Nachr

nACHr


End plate potential

End-plate potential

  • Larger

  • Longer

  • Leads to Ca+ influx in sarcolema of muscle

    • Ca+ causes muscle contraction


Disease of the nmj mg

Disease of the NMJ? MG


Motor systems

MG


Muscle fibers encase myofibrils the casing is called the sarcolema

muscle fibers encase myofibrils. The casing is called the sarcolema

Muscle group

myofibril

Muscle fiber


End plate potential causes ca influx into sarcolemma

End-plate potential causes ca+ influx into sarcolemma


Myofibrils in turn contain actin and myosin filaments

Myofibrils in turn contain “Actin and Myosin” filaments


When the nmj is activated actin myosin interact to shorten the length of a muscle fiber

When the NMJ is activated Actin-myosin interact to shorten the length of a muscle fiber


Sliding filament model of muscular contraction

Sliding filament model of muscular contraction


Muscle shortens work

Muscle shortens=work


Cortical vs spinal control of behavior

Goal-directed

Complex

Higher levels of control

Plastic

Numerous reflexive behaviors are involved

Reflexive

Simple

Automatic

inplastic

Cortical vs Spinal control of behavior


Spinal reflex arcs

Spinal reflex ARCs

  • Monosynaptic

    • stretch

  • Polysynaptic

    • Withdrawal

    • Antagonist muscle groups

    • Synergistic muscle groups

    • Polysegmental relexes

    • Cross-spinal reflexes


A monosynaptic spinal reflex arc the stretch reflex

A “monosynaptic” spinal reflex arc- the Stretch reflex


The stretch reflex involves neuromuscular spindles

The stretch reflex involves neuromuscular “spindles”


Stretch reflex regulates muscle tension in every muscle group

Stretch reflex regulates muscle tension in every muscle group


The polysynaptic part of stretch reflexes inhibition of antagonist muscles

The polysynaptic part of stretch reflexes: inhibition of Antagonist muscles


Spinal inhibition of antagonist muscles require inhibitory interneurons

Spinal inhibition of antagonist muscles require inhibitory interneurons


The withdrawal reflex arc a polysynaptic spinal reflex

The “withdrawal reflex arc” a polysynaptic spinal reflex


Also involves interneurons

Also involves interneurons


And may involve more than one spinal cord segment

And may involve more than one spinal cord segment


And or cross spinal reflex arcs

And/or Cross spinal reflex arcs


The goli tendon organ gto reflex

The Goli tendon organ (GTO) reflex


Neural activity of spinal neurons related to whole muscle group activity

Neural activity of spinal neurons related to whole muscle group activity


Lower motor neurons the final common pathway

Lower motor neurons “the final common pathway”


Goal directed behavior and reflexive behavior

Goal-Directed Behavior and Reflexive Behavior


Goal directed behaviors require

Goal-Directed Behaviors Require:

  • Goal selection and prioritization

  • Resistance to distracters

    -Cross-modal Sensory integration

    • Perception of target

    • Awareness of location of movable body part

    • Ability to aim movement of body part

    • Ability to detect errors and re-adjust, (use feedback)

    • Ability to use feedback to control movement of body part


Sensory motor integration in the frontal lobes

Sensory-Motor Integration in the frontal lobes


The dlpfc the conductor

THE DLPFC: “The conductor”

Integrates cross modal input- may initiate goal-directed behaviors

Lesions of the dorsolateral frontal areas results in a number of “executive” motor impairments. These include perseveration, incoordination, motor impersistence, apraxias and hypokinesia.


The premotor and supplementary motor ctx the sections

The premotor and supplementary motor ctx: “The sections”

Stimulation= complex sequences of behavior (aimless behavior)


Damage to the secondary motor cortex

Damage to the secondary Motor Cortex?

  • Ideomotor Apraxia

  • This apraxia is associated with great difficulty in the sequencing and execution of movements. A common test of apraxia is to request the patient to demonstrate the use of a tool or household implement (e.g., "Show me how to cut with scissors"). Difficulties are apparent when the patient moves the hand randomly in space or uses the hand as the object itself, such as using the forefinger and middle finger as blades of the scissors. They have additional trouble sequencing the correct series of movements and make errors in orienting their limbs in space consistent with the desired action. Imitation of the movements of others will usually improve performance but it is still usually defective.

  • Memories for skilled acts are probably stored in the angular gyrus of the parietal lobe in the left hemisphere.


The primary motor cortex the instrument

The primary motor cortex; “the instrument”

Stimulation = relatively simple fragments of behavior


Two major descending pathways from the primary motor cortex the dorsolateral pathway

TWO MAJOR DESCENDING PATHWAYS FROM THE PRIMARY MOTOR CORTEX: The Dorsolateral pathway


And the vm path

And the VM Path.

  • The VM pathway does not discretely decussate, but does branch and innervate contra lateral segments in the spinal cord.


Dl vs vm descending motor paths

Dorsolateral

Decussates at medullary pyramids

Distal muscle groups

More direct

More volitional control

Higher resolution of control

Ventromedial

Does not cross

Medial muscle groups

Gives off spinal collaterals

Yoking

Lower resolution of control

DL vs VM descending motor paths


Other motor pathways

Other Motor Pathways

  • In addition there are other motor paths that have relays in the brainstem

  • These other paths innervate nuclei of the RAS, cranial nerve nuclei, etc…


Descending paths get additional inputs

Descending paths get additional inputs


Both pathways terminate in spinal cord segments

Both pathways terminate in spinal cord segments


According to part of the body they control

According to part of the body they control


On lower motor neurons alpha motor neurons

On lower motor neurons (alpha motor neurons)


Amyotropic lateral sclerosis als disease of the alpha motor neurons

Amyotropic lateral sclerosis (ALS)disease of the alpha motor neurons


Motor systems

ALS


Alpha motor neurons project to form part of spinal nerve pairs

Alpha motor neurons project to form part of spinal nerve pairs


Terminate on muscle fibers

Terminate on muscle fibers


At each spinal segment

At each spinal segment


Basal ganglia

BASAL GANGLIA

  • Nigro-striatal Pathway

  • Striato-Pallidal pathway


Basal ganglia1

Basal Ganglia

  • Neostriatum

    • Caudate (kaw-date) nucleus and putamen (pew-TAY-men)

  • Globus Pallidus ( GLOB-us PAL-i-dos)

  • Substantia nigra (included by functional not anatomical relationship)

  • Subthalamus

  • others


Basal ganglia complex ccts

Basal ganglia- Complex ccts

The basal ganglia are involved in motor regulation, but are only one component of the control of behavior. The way in which the basal ganglia controls movement is complicated and not completely understood, but at his time may be fairly described as the gate-keeper of movement. Disorders of the basal ganglia can either lead to too much behavior or too little behavior.


Motor systems

Basal Ganglia-Neostriatum

( composed of the caudate nucleus and the Putamen)


The nigro striatal pathway the behavioral grease system

The Nigro-striatal pathway- the behavioral “grease” system


Motor systems

The Globus Pallidus ( the striato-pallidal circuit= the behavioral “brakes” system)


Basal ganglia syndromes too much or too little behavior

Basal Ganglia Syndromestoo much or too little behavior

  • Damage to the Nigro-striatal pathway

    • Parkinsons (not enough behavior)

    • http://video.google.com/videosearch?hl=en&rls=GGIC,GGIC:2007-01,GGIC:en&um=1&q=parkinsons&ndsp=20&ie=UTF-8&sa=N&tab=iv#

    • http://video.google.com/videosearch?hl=en&rls=GGIC,GGIC:2007-01,GGIC:en&um=1&q=parkinsons&ndsp=20&ie=UTF-8&sa=N&tab=iv#


Basal ganglia syndromes

Basal Ganglia syndromes

  • Strato-Pallidal Pathway- too much behavior

    • Huntingtons

    • Tourettes’

    • Balisms

    • Others


Motor systems

  • Huntington's Chorea is principally characterized by hyperkinesias - abnormal, purposeless, involuntary motor movements that can occur spontaneously or only when the patient is trying to do something. These movements may be repetitive or non-repetitive.


Tourettes syndrome

Tourettes Syndrome

  • TS usually becomes apparent in children between ages 2 to 15, with approximately 50% of patients affected by age 7. The age of symptom onset is typically before the age of 18. TS is more frequent in males than females by a ratio of about 3 or 4 to 1. The disorder is thought to affect 0.1% to 1.0% of individuals in the general population.


Tourettes

Tourettes

  • Motor ticsInitially, patients develop sudden, rapid, recurrent, involuntary movements (motor tics), particularly of the head and facial area. At symptom onset, motor tics usually consist of abrupt, brief, isolated movements known as simple motor tics, such as repeated eye blinking or facial twitching. Simple motor tics may also include repeated neck stretching, head jerking, or shoulder shrugging. Less commonly, motor tics are more "coordinated," with distinct movements involving several muscle groups, such as repetitive squatting, skipping, or hopping. These tics, referred to as complex motor tics, may also include repetitive touching of others, deep knee bending, jumping, smelling of objects, hand gesturing, head shaking, leg kicking, or turning in a circle. In addition to affecting the head and facial area, motor tics also affect other parts of the body, such as the shoulders, torso, arms, and legs. The anatomical locations of motor tics may change over time. Rarely, motor tics evolve to include behaviors that may result in self-injury, such as excessive scratching and lip biting.


Vocal tics

Vocal tics

  • Vocal tics are sudden, involuntary, recurrent, often relatively loud vocalizations. Vocal tics usually begin as single, simple sounds that may eventually progress to involve more complex phrases and vocalizations. For example, patients may initially develop simple vocal tics, including grunting, throat clearing, sighing, barking, hissing, sniffing, tongue clicking, or snorting. Complex vocal tics may involve repeating certain phrases or words out of context, one's own words or sounds (palilalia), or the last words or phrases spoken by others (echolalia). Rarely, there may be involuntary, explosive cursing or compulsive utterance of obscene words or phrases (coprolalia).


Limbic structures

LIMBIC STRUCTURES

  • AMYGDALAHIPPOCAMPUSSEPTUM


Affective impusles

AFFECTIVE IMPUSLES

  • The 4-F’s, but different


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