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Today:. Quiz 7 Hormones and the Endocrine System. How Does an Animal Body Communicate to Coordinate Function?. Two Options The nervous system Signaling Molecules! (the Endocrine System ) Types and Functions??. Types of Signaling Events. Types of Hormones.

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Today

Today:

Quiz 7

Hormones and the Endocrine System


How does an animal body communicate to coordinate function

How Does an Animal Body Communicate to Coordinate Function?

Two Options

  • The nervous system

  • Signaling Molecules! (the Endocrine System)

    Types and Functions??


Types of signaling events

Types of Signaling Events


Types of hormones

Types of Hormones

Usually categorized by structure and mode of synthesis.

Useful Idea: Where will the targets of each of these molecules have to be???


Predicting reception location

Predicting Reception Location


Signaling by water soluble hormones

Signaling by Water-Soluble Hormones

Can trigger activation of enzymes, uptake or secretion, rearrangement of cytoskeleton, or transcription changes

Example: Epinephrine

How should your blood sugar level respond to a surge in epinephrine (adrenaline)?


Cell surface reception usually requires signal transduction

Cell-Surface Reception Usually Requires Signal Transduction

Let’s Watch:

http://www.youtube.com/watch_popup?v=V_0EcUr_txk


Intra cellular receptors for lipid soluble hormones

Intra-Cellular Receptors for Lipid Soluble Hormones


Aside interesting application of vg expression

Aside: Interesting Application of Vg Expression?

Vitellogenin Gene Expression in Male Fathead Minnow as an Indicator of Exposure to Endocrine Disrupting Chemicals (EDCs) in an Aquatic Environment

Objective:

To develop molecular tools for monitoring fish exposures to EDCs implicated in feminization of male fish around the world and in USA, that are present in surface waters, effluents from sewage treatment plants and sediments


Multiple responses from a single hormone back to epinephrine

Multiple Responses From a Single Hormone: Back to Epinephrine


An aside so why epi pens

An Aside: So Why Epi-Pens??

In Anaphylaxis, patients experience bronchial constriction and systemic vasodilation...


Localized signaling

Localized Signaling

Can be paracrine (from neighboring cells) or autocrine (same cell)

Fast!

Examples: cytokines, growth factors, nitric oxide (NO), prostoglandins


Negative feedback in the endocrine system supports homeostasis

Negative Feedback in the Endocrine System Supports Homeostasis

Homeostatic challenges in your duodenum??


Paired pathways insulin and glucagon

Paired Pathways: Insulin and Glucagon

Ideal Blood Sugar: 90-100mg/100mL

Balanced by two negative feedback loops (antagonists!)


Adding the nervous system to the story

Adding the Nervous System to the Story

Neurohormones play critical functions in reproduction and metamorphosis in invertebrates

Example: prophoracicotrophic hormone (PTTH) triggers ecdysis and metamorphosis


Vertebrate coordination of endocrine and nervous systems

Vertebrate Coordination of Endocrine and Nervous Systems

Hypothalmus: endocrine gland in the brain of vertebrates


Vertebrate coordination of endocrine and nervous systems1

Vertebrate Coordination of Endocrine and Nervous Systems

Oxytocin: Positive-feedback mechanism involved in release of milk from mammary glands and uterine contraction


Vertebrate coordination of endocrine and nervous systems adh

Vertebrate Coordination of Endocrine and Nervous Systems: ADH

What would an Anti-Diuretic Hormone (ADH) do? When would I produce it?


Vertebrate coordination of endocrine and nervous systems adh1

Vertebrate Coordination of Endocrine and Nervous Systems: ADH


Vertebrate coordination of endocrine and nervous systems2

Vertebrate Coordination of Endocrine and Nervous Systems

  • Anterior pituitary produces a variety of tropic and nontropic hormones

  • Tropic hormones regulate the function of endocrine cells or glands. Example: TSH

  • Nontropic hormones target nonendocrine tissues. Example: MSH


Vertebrate coordination of endocrine and nervous systems3

Vertebrate Coordination of Endocrine and Nervous Systems


Vertebrate coordination of endocrine and nervous systems4

Vertebrate Coordination of Endocrine and Nervous Systems

These impacts make GH tempting for adult athletes to abuse!

A few hormones, like Growth Hormone (GH) have both tropic and nontropic effects


Today

LONDON – In a major breakthrough in the fight against doping, a British rugby league player has become the first athlete to be suspended for using human growth hormone.

Terry Newton admitted taking the substance in a statement released by his attorneys on Friday. The United Kingdom Anti-Doping authority announced a two-year ban on Monday after Newton was fired by his club, Wakefield.

"It's the first time and very significant," WADA director general David Howman said. "It shows the people who say that HGH cannot be detected that it can. The sports people who said it can't be detected are fooling themselves."

Rugby player makes history with growth hormone ban

By ROBERT MILLWARD, AP Sports Writer Robert Millward, Ap Sports Writer – Mon Feb 22, 2010 2:48 pm ET


Example tsh a tropic hormone acts in a hormone cascade

Example: TSH, a tropic hormone, acts in a hormone cascade


Functions of the thyroid hormone

Functions of the Thyroid Hormone

Involved in both homeostasis (blood pressure, heart rate, etc.) and development

Excessive secretion = hyperthyroidism (high temp, high blood pressure, weight loss)

Insufficient production = hypothyroidism (weight gain, lethargy, intolerance to cold)


Today

Iodine was added to salt in 1924 when up to a third of US adults suffered from goiter!


Controlling calcium ca 2

Controlling Calcium (Ca2+)


Stress and the adrenal gland

Stress and the Adrenal Gland


Moving on to applications

Moving on to Applications


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