1 / 22

Iridium Catalyst System for Transfer Hydrogenation

Iridium Catalyst System for Transfer Hydrogenation. Wu Hua 2012-6-9. Iridium Hydride Complex Catalyzed Addition of Nitriles to Carbon-Nitrogen Triple Bonds of Nitriles.

penelope-morrow
Download Presentation

Iridium Catalyst System for Transfer Hydrogenation

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Iridium Catalyst System for Transfer Hydrogenation Wu Hua 2012-6-9

  2. Iridium Hydride Complex Catalyzed Addition of Nitriles to Carbon-Nitrogen Triple Bonds of Nitriles A mixture of nucleophile (1.0 mmol), nitrile (2.0 mmol), and IrH(CO)(PPh3)3 (3 mol %) in dry THF (0.25 mL) was stirred at 120 °C for 12 h under argon. Mechanism: Shun-Ichi Murahashi. J. Am. Chem. Soc. 1998, 120, 4244-4245

  3. A Three-Component Coupling Reaction of Aldehydes, Amines, and Alkynes Yasutaka Ishii. Angew. Chem. Int. Ed. 2001, 40, 2534-2536

  4. N-Alkylation of amines with alcohols catalyzed by a Cp*Ir complex Substrates: Ken-ichi Fujita, Ryohei Yamaguchi. Tetrahedron Letters. 2003, 44, 2687–2690

  5. Mechanism:

  6. An Efficient Direct r-Alkylation of Ketones with Primary Alcohols Catalyzed by [Ir(cod)Cl]2/PPh3/KOH System without Solvent Kazuhiko Taguchi, Yasutaka Ishii. J. Am. Chem. Soc. 2004, 126, 72-73

  7. Kazuhiko Taguchi, Yasutaka Ishii. J. Am. Chem. Soc. 2004, 126, 72-73

  8. Mechanism: Kazuhiko Taguchi, Yasutaka Ishii. J. Am. Chem. Soc. 2004, 126, 72-73

  9. Catalytic Reductive Alkylation of Secondary Amine with Aldehyde and Silane by an Iridium Compound Tomoya Mizuta, Satoshi Sakaguchi, and Yasutaka Ishii. J. Org. Chem. 2005, 70, 2195-2199

  10. Plausible Mechanism: Tomoya Mizuta, Satoshi Sakaguchi, and Yasutaka Ishii. J. Org. Chem. 2005, 70, 2195-2199

  11. Guerbet Reaction of Primary Alcohols Mechanism of Guerbet reaction: Yasutaka Ishii. J. Org. Chem. 2006, 71, 8306-8308

  12. New Coupling Reaction of Secondary Amines, Aldehydes, and Alkynes Catalyzed by an Iridium Complex Mechanism: Yasutaka Ishii.Org. Lett. 2006, 8, 2459-2462

  13. Oxidative dimerization of primary alcohols to esters catalyzed by iridium complexes Yasutaka Ishii. Tetrahedron Lett. 2006, 47, 9199–9201

  14. Alkylation of active methylene compounds with alcohols catalyzed by an iridium complex Mechanism: Yasutaka Ishii. Chem. Commun. 2007, 2850–2852

  15. Synthesis of Diketones and ω -Hydroxy Ketones from Methyl Ketones and , α,ω –Diols by an [IrCl(cod)]2/PPh3/KOH System Yasutaka Ishii. Bull. Chem. Soc. Jpn. 2008, 81, 689–696 Iridium-Catalyzed α-Alkylation of Acetates with Primary Alcohols and Diols Yasutaka Ishii. J. Am. Chem. Soc. 2010, 132, 2536–2537

  16. N-Heterocyclization of Naphthylamines with 1,2- and 1,3-Diols Catalyzed by an Iridium Chloride/BINAP System Yasutaka Ishii. J. Org. Chem. 2009, 74, 628–633

  17. Yasutaka Ishii. J. Org. Chem. 2009, 74, 628–633

  18. Iridium-Catalyzed Coupling Reaction of Primary Alcohols with 1-Aryl-1-propynes Leading to Secondary Homoallylic Alcohols Yasutaka Ishii. Org. Lett., 2009, 11, 3510-3513

  19. Iridium-Catalyzed Coupling Reaction of Primary Alcohols with 1-Aryl-1-propynes Leading to Secondary Homoallylic Alcohols A Plausible Reaction Mechanism: Yasutaka Ishii. Org. Lett., 2009, 11, 3510-3513 Yasutaka Ishii. Chem. Eur. J. 2010, 16, 1883 – 1888

  20. Iridium-Catalyzed Reactions of w-Arylalkanols to α,ω –DiarylalkanesDiarylalkanes Yasutaka Ishii. Angew. Chem. Int. Ed. 2011, 50, 8618 –8622

  21. Yasutaka Ishii. Angew. Chem. Int. Ed. 2011, 50, 8618 –8622

  22. Summary a. Reaction Temperature b. Rh, Ru, Ni c. Development of hydrogen transfer reactions

More Related