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Capstone as a Vehicle for Translational Research

Capstone as a Vehicle for Translational Research. Timothy Allen, Ph.D. David Chen (UVA Coulter Director) Shayn Peirce, Ph.D. The DEPARTMENT of BIOMEDICAL ENGINEERING School of Engineering and Applied Science  School of Medicine. Clinical Problem: Otitis Media with Effusion (OME).

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Capstone as a Vehicle for Translational Research

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  1. Capstone as a Vehicle for Translational Research Timothy Allen, Ph.D. David Chen (UVA Coulter Director) Shayn Peirce, Ph.D. TheDEPARTMENT ofBIOMEDICAL ENGINEERING School of Engineering and Applied Science  School of Medicine

  2. Clinical Problem: Otitis Media with Effusion (OME) • Fluid in middle ear • Symptoms of ear pressure, • fullness, hearing loss, and • balance difficulties • Untreated, OME can cause permanent hearing • loss and speech and language difficulties – • seen most commonly in children

  3. Current Standard of Care Treatment Myringotomy with ventilation tube insertion: • Decreases pain • Restores hearing • Prevents reaccumulation • of fluids • Ventilates middle ear space • Improves balance

  4. Clinical Need: Improve existing surgical technique • Instruments unable to hold and precisely manipulate the small ear tubes; multiple instruments required to insert the tube  risk of damage to ear canal

  5. It started with a BME Capstone Team... Orthopaedic Surgery Michael Pannunzio, M.D. Kornelis Poelstra, M.D. Otolaryngology Brad Kesser, M.D. Biomedical Engineering Shayn Peirce-Cottler, Ph.D. Anu Roy Lisa Killen Danielle Gause Early Prototypes Prototype 2A Prototype 1A

  6. Provisional Patent Identify Potential Licensees NDAs It continued with a Capstone Team... Otolaryngology Brad Kesser, M.D. Nursing Deborah Conway, R.N., M.S.N. Biomedical Engineering Shayn Peirce-Cottler, Ph.D. Isi Azeke Craig Conta Ashley Davenport Kristen Melnyczuk Trevor Royce Daniel Walters Prototype 1B

  7. Pre-clinical Trial, Clinical Trial, &International Licensing Deal Time Required for Ear Tube Insertion 150 125 100 p = 0.062 Time (seconds) 75 50 25 0 Standard of Care PROTOTYPE 1B Chinchilla Model

  8. Capstone as a Mechanism for Upstream Innovation • How can we involve BME undergraduates in translational research? • How can involving our undergraduates in translational research bolster an environment of innovation? • Research for credit • Capstone sequence • “Project Fair” • Topics include design, IP, market research, and FDA regulation • Fall Proposal & Spring Capstone Symposium • Novel design-for-credit course (“D-teams”), funded by NCIIA • Many of our students are medically-motivated… and creative! • Interdisciplinary Solutions Workshops • High-throughput (Capstone “incubator” for new ideas)

  9. U.Va. BME Capstone Design Achievements over Three Years (avg. 53 students/yr)

  10. Challenges • Intellectual property (…who owns it?) • Timing issues related to the academic calendar • Continuing the project over consecutive years and offering the same types of “design” experiences

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