Acute renal failure from hemolytic transfusion reactions. Brad Weaver, MD 9/25/07. Acute hemolytic transfusion reaction. ABO incompatability is the major cause of death from transfusion
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Acute renal failure from hemolytic transfusion reactions
Brad Weaver, MD
Alpha-Beta dimers MW 34,000 -- small enough to be filtered by glomerulus
1. Obstruction of tubules with heme pigment casts
2. Oxidative damage to proximal tubule by released free iron
Low FENa characteristic