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ANTIFUNGAL AGENT BY PAYAL N. KHANDAIT

In these Presentation, Describe about Antifungal Agents, it's classification, Drug Information

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ANTIFUNGAL AGENT BY PAYAL N. KHANDAIT

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  1. ANTIFUNGALAGENT Prepared by MISS. PAYAL NILKANTH KHANDAIT Lecturer, C.S.C.P. Deori

  2. Content • Defination. • Classification. • Drug Information -- Structure. --Chemical Name. -- Physical Properties. -- Chemical Properties. -- Stability & Storage. -- Uses. -- Pharmaceutical Preparation.

  3. DefinationThese are the drug or the agent which are used to treat variety of fungal infection called as antifungal agent. • An antifungal agents have been generally used in the treatment of infection of hair, mucous membrane, nails or skin by the fungi of genera candida (candidiasis) , Epidermophyte, Trichophyton.

  4. Classification • Synthetic Compounds:- • Carboxylic acids and their metallic salt Ex- Undecylenic acid ( Undecenoic acid), Zinc undecenonate ii) Dyes Ex- Gentain violet (crystal violet) , malachite green iii) Phenolic compound-Salicylic acid iv) Diamidines- Stilbamidine v)Thiocarbanilic acid derivative- Tolnaflate vi) Azole- Miconazole, Clotrimazole

  5. B) Natural product:- Antibiotics:- • Antibacterial antibiotics- Griseofulvin b) Polyene antifungal antibiotics • Tetraenes- Nystatin, amphotericin-A • Pentaenes- Pentamycin iii) Heptanenes- Amphotericin B, hamycin

  6. 1) UNDECYLENIC ACID OR UNDECENOIC ACID It mainly consist of undec-10-enoic acid CH2=CH- (CH2)8-COOH Properties:- Colour- Colourless or pale brownish clear liquid or white to yellowish crystalline mass Odour- Charecteristic Solubility- It is insoluble in water but miscible in alcohol and chloroform

  7. CHEMICAL PROPERTIES • It decolourise aqueous solution of potassium permagnate, indicating presence of double bond in compound STABILITY & STORAGE:- It is affected by light &hence it is stored in tightly-closed, light- resistant container.

  8. USES • It is used as topical fungicidal • Internally, it is used to treat a)Psoriasis b)Neurodermatitis PHARMACEUTICAL FORMULATION:- • Compound undecylenic acid ointment • zinc undecenoate dusting powder BRAND NAME- Mycota, Tinefax

  9. 2) TOLNAFTATE • It is an ester of b- napthol PHYSICAL PROPERTIES- COLOUR- White to Creamy-White powder ODOUR- Odourless /Slight odour Solubility - Insoluble in water , Very slightly soluble in alcohol but freely soluble in chloroform STABILITY & STORAGE:- It is stored in tightly-closed container.

  10. USES:- • It is Topical antifungal agent • It is used for prophylaxis and treatment of various form of ringworm • It is effective against skin infection due to epidermophyton spp, PHARMACEUTICAL FORMULATION:- 1) Tolnaftate topical solution 2) Tolnaftate powder 3) Tolnaftate topical aerosol 4) Tolnaftate cream 5) Tolnaftate gel BRAND NAME:- Tanacidal, Multiderm, Mycil

  11. 3) NYSTATIN PHYSICAL PROPERTIES COLOUR- Yellow to light brown powder ODOUR- Cereal like Solubility - slightly soluble in water and alcohol STABILITY AND STORAGE:-It is hygroscopic &it is affected by room temperature , light & air. It is affected by light &hence it is stored in tightly-closed, light- resistant container.

  12. USES:- • For prophylaxis & treatment of candiasis of skin and mucous membrane • For treatment of intestinal & Oesophagael candiasis • For candiasis of mouth • For candiasis of vagina PHARMACEUTICAL FORMULATION:- 1)Nystatin Tablet 2) Nystatin Oral suspension 3) Nystatin cream 4) Nystatin eye drop 5) Nystatin lotion 6) Nystatin ointment 7) Nystatin vaginal tablet 8) Nystatin topical powder BRAND NAME- Nystan, Nystaform, Nystadermal

  13. AMPHOTERICIN-B • PHYSICAL PROPERTIES:- Colour- Yellow to orange powder Odour- odourless Taste- Tasteless Solubility- Insoluble in water, in alcohol, but soluble in dimethyl sulphoxide and in propylene glycol. Chemical property:-When it is treated with phosphoric acid solution, a deep blue colour is produced

  14. Stability and storage:- • It is affected by light, air and room temperature. Hence, it is stored in tightly closed , light resistant container USES- • It is used in the treatment of mucocutanenous and and cutaneous Leishmaniasis and candidiasis. 2) It is used for suppression of oral or intestinal candidiasis.

  15. Pharmaceutical formulation:- • Amphotericin B cream. • Amphotericin B lotion. • Amphotericin logenges. • Amphotericin B injection.

  16. Brand names: • Fungizone, Fungilin.

  17. HAMYCIN ( PRIMAMYCIN) Physical properties :- Colour- Yellow amorphous powder. Solubility – Soluble in water and in chloroform, insoluble in pyridine. Chemical properties:- When it is treated with conc. H2SO4 it gives stable blue colour Storage- It is affected by light & air and hence it is stored in tightly closed container.

  18. USES:- • It has antifungal and antitrichomonal activity . • It is used topically and orally in various fungal infections. PHARMACEUTICAL FORMULATION- • Hamycin ointment • Hamycin vaginal tablets. Brand names: - Imprina.

  19. Thank you

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