Dna for dummies and the intellectually astute
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DNA for Dummies (and the intellectually astute). A Dr. Parrott Production. Secret of Photo 51 : What organic polymer? Made of what monomers? Components?. Tour of the Basics. DNA Wrap Basic DNA Wrap Advanced DNA Coiling. Replication: DNA  DNA.

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DNA for Dummies (and the intellectually astute)

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DNA for Dummies(and the intellectually astute)

A Dr. Parrott Production


  • Secret of Photo 51:

  • What organic polymer?

  • Made of what monomers?

  • Components?

Tour of the Basics


DNA Wrap Basic

DNA Wrap Advanced

DNA Coiling


Replication: DNADNA

  • Occurs during S phase of interphase in reproducing cells only

  • DNA template is copied complimentarily and semi conservatively

  • Occurs only in the nucleus


Meselson-Stahl ExperimentHow DNA ReplicatesDNA Replication

Bidirectional ReplicationReplication CompleteGeneral DNA Workshop


Make a DNA strand complimentary to the following:

DNA1: ATGGTG CAC CTG ACT CCT GTG GAG AAG TCT

DNA2: TAC

mRNA:

Amino Acids:

tRNA:

replication


DNA Replication Basic DNA Replication ForkRep Fork 2

DNA Replication DNA Polymerase


Transcription: DNAmRNA

  • Occurs continually throughout the cell cycle with the exception of mitosis

  • Occurs in the nucleus as messenger RNA copies DNA


RNA Splicing TranscriptionTranscription Complete

Transcription the MovieRegulated Transcription


Make a DNA strand complimentary to the following:

DNA1: ATGGTG CAC CTG ACT CCT GTG GAG AAG TCT

DNA2: TAC

Transcribe the above DNA template into an mRNA:

mRNA: UAC

Amino Acids:

tRNA:

transcription


Translation: mRNAprotein

  • Occurs continually throughout the cell cycle

  • Occurs at the ribosome as it

    • reads the mRNA codons

    • Matches codons to amino acids

    • Prompts tRNA to bring a.a.

    • Attaches a.a. with peptide bonds

DNA to Protein2

PP Synthesis Walkthrough


Translation

  • tRNA anticodon is complimentary to mRNA codon

  • tRNA is specific to the amino acid it brings

  • Peptide bonds connect amino acids to form polypeptide (protein)

Translation BasicTranslation AdvancedProtein Synthesis

Protein Synthesis 2Translation the Movie


Protein Synthesis = Transcription + Translation = DNA  proteins


Make a DNA strand complimentary to the following:

DNA: ATGGTG CAC CTG ACT CCT GTG GAG AAG TCT

DNA: TAC

mRNA (codons): UAC

Translate the above mRNA strand into an amino

acid sequence (protein)

Amino Acids: Tyrosine

tRNA (anticodons):

translation


  • Watch RNAi Online: http://www.pbs.org/wgbh/nova/sciencenow/3210/02.html


Make a DNA strand complimentary to the following:

DNA: ATGGTG CAC CTG ACT CCT GTG GAG AAG TCT

DNA: TAC

mRNA (codons): UAC

Amino Acids: Tyrosine

What are the anticodons on the tRNA for the above strands?

tRNA (anticodons): AUG


To summarize…

Protein Synthesis


Mistakes/Mutations

  • Mutation any permanent alteration in the sequence of DNA bases

  • Mutagen causes a mutation i.e. chemicals, radiation, spontaneous

    • Point mutations can result in frameshifts in the reading frame

    • Chromosomal mutations can result in translocations

    • Immortal Thread


Mistakes/Mutations

  • Silent mutation change in n.t. sequence, but no change in product

  • Missense mutation swapping of a.a. (sickle cell anemia, PKU)

  • Nonsense mutation insertion of stop codon into sequence

    • Mutations & Sickle Cell, 2

    • How Cancer Grows, 2

    • Evolutionary Arms Race: HIV Resistance, 2

Silent Mutation

G


Resources

  • DNA Learning Center: 3D Animations

  • Genetics Movies:

  • DNA Tutorial:

  • Bacterial Replication Animations:

  • Telomere Synthesis (shortening of linear chromosomes):

  • Gene Processing

  • Replication Animations:

  • Gene Expression Animations:

  • Gene Technology:

  • DNA the Secret of Life Video

  • Cracking the Code of Life Video

  • Beadle-Tatum Experiments (one gene, one pp)

  • Protein Synthesis Tutorial


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