Dna for dummies and the intellectually astute
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DNA for Dummies (and the intellectually astute). A Dr. Parrott Production. Secret of Photo 51 : What organic polymer? Made of what monomers? Components?. Tour of the Basics. DNA Wrap Basic DNA Wrap Advanced DNA Coiling. Replication: DNA  DNA.

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DNA for Dummies (and the intellectually astute)

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Dna for dummies and the intellectually astute

DNA for Dummies(and the intellectually astute)

A Dr. Parrott Production


Dna for dummies and the intellectually astute

  • Secret of Photo 51:

  • What organic polymer?

  • Made of what monomers?

  • Components?

Tour of the Basics


Dna for dummies and the intellectually astute

DNA Wrap Basic

DNA Wrap Advanced

DNA Coiling


Replication dna dna

Replication: DNADNA

  • Occurs during S phase of interphase in reproducing cells only

  • DNA template is copied complimentarily and semi conservatively

  • Occurs only in the nucleus


Dna for dummies and the intellectually astute

Meselson-Stahl ExperimentHow DNA ReplicatesDNA Replication

Bidirectional ReplicationReplication CompleteGeneral DNA Workshop


Dna for dummies and the intellectually astute

Make a DNA strand complimentary to the following:

DNA1: ATGGTG CAC CTG ACT CCT GTG GAG AAG TCT

DNA2: TAC

mRNA:

Amino Acids:

tRNA:

replication


Dna for dummies and the intellectually astute

DNA Replication Basic DNA Replication ForkRep Fork 2

DNA Replication DNA Polymerase


Tran script ion dna mrna

Transcription: DNAmRNA

  • Occurs continually throughout the cell cycle with the exception of mitosis

  • Occurs in the nucleus as messenger RNA copies DNA


Dna for dummies and the intellectually astute

RNA Splicing TranscriptionTranscription Complete

Transcription the MovieRegulated Transcription


Dna for dummies and the intellectually astute

Make a DNA strand complimentary to the following:

DNA1: ATGGTG CAC CTG ACT CCT GTG GAG AAG TCT

DNA2: TAC

Transcribe the above DNA template into an mRNA:

mRNA: UAC

Amino Acids:

tRNA:

transcription


Translation mrna protein

Translation: mRNAprotein

  • Occurs continually throughout the cell cycle

  • Occurs at the ribosome as it

    • reads the mRNA codons

    • Matches codons to amino acids

    • Prompts tRNA to bring a.a.

    • Attaches a.a. with peptide bonds

DNA to Protein2

PP Synthesis Walkthrough


Translation

Translation

  • tRNA anticodon is complimentary to mRNA codon

  • tRNA is specific to the amino acid it brings

  • Peptide bonds connect amino acids to form polypeptide (protein)

Translation BasicTranslation AdvancedProtein Synthesis

Protein Synthesis 2Translation the Movie


Dna for dummies and the intellectually astute

Protein Synthesis = Transcription + Translation = DNA  proteins


Dna for dummies and the intellectually astute

Make a DNA strand complimentary to the following:

DNA: ATGGTG CAC CTG ACT CCT GTG GAG AAG TCT

DNA: TAC

mRNA (codons): UAC

Translate the above mRNA strand into an amino

acid sequence (protein)

Amino Acids: Tyrosine

tRNA (anticodons):

translation


Dna for dummies and the intellectually astute

  • Watch RNAi Online: http://www.pbs.org/wgbh/nova/sciencenow/3210/02.html


Dna for dummies and the intellectually astute

Make a DNA strand complimentary to the following:

DNA: ATGGTG CAC CTG ACT CCT GTG GAG AAG TCT

DNA: TAC

mRNA (codons): UAC

Amino Acids: Tyrosine

What are the anticodons on the tRNA for the above strands?

tRNA (anticodons): AUG


To summarize

To summarize…

Protein Synthesis


Mistakes mutations

Mistakes/Mutations

  • Mutation any permanent alteration in the sequence of DNA bases

  • Mutagen causes a mutation i.e. chemicals, radiation, spontaneous

    • Point mutations can result in frameshifts in the reading frame

    • Chromosomal mutations can result in translocations

    • Immortal Thread


Mistakes mutations1

Mistakes/Mutations

  • Silent mutation change in n.t. sequence, but no change in product

  • Missense mutation swapping of a.a. (sickle cell anemia, PKU)

  • Nonsense mutation insertion of stop codon into sequence

    • Mutations & Sickle Cell, 2

    • How Cancer Grows, 2

    • Evolutionary Arms Race: HIV Resistance, 2

Silent Mutation

G


Resources

Resources

  • DNA Learning Center: 3D Animations

  • Genetics Movies:

  • DNA Tutorial:

  • Bacterial Replication Animations:

  • Telomere Synthesis (shortening of linear chromosomes):

  • Gene Processing

  • Replication Animations:

  • Gene Expression Animations:

  • Gene Technology:

  • DNA the Secret of Life Video

  • Cracking the Code of Life Video

  • Beadle-Tatum Experiments (one gene, one pp)

  • Protein Synthesis Tutorial


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