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新药研发技术前沿 2 PowerPoint PPT Presentation


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新药研发技术前沿 2. 彭雷 08.12. 检测. 把未知信号或者现象与已知信号(多用电信号)相关联,尤其是寻找到线性关联部分,用以对未知信号的计量。. FPLC 全称为快速蛋白液相色谱( Fast protein liquid chromatography ),其原理与高效液相色谱理论类似,是由经典的液体柱层析引入气相色谱理论,并且对相体进行了改革,配用高压输液泵,采用高灵敏检测器、梯度洗脱装置、自动收集装置和微机等发展起来的现代液相色谱。

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新药研发技术前沿 2

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08.12


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  • FPLCFast protein liquid chromatography

  • FPLCHPLCHPLC


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  • Non-invasive Micro-test Technique, NMT1990 [1]

  • H+Ca2+K+NH4+Al3+Na+Cd2+NO3-Cl-O2CO2NO[23]


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  • BDFACSArray

  • 15000/FACSArray BDCBACytometric BeadArray


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GSNONO

NO

J. Am. Chem. Soc. 2009, 131, 40-41


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  • 400

  • 1IGF-1


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  • HP-CD 400P-GP-Her-2/neuHerceptin


2

  • HIV-I


Nanomedicine

Nanomedicine

  • CytImmune

  • NucrystAntimicrobial wound dressings using silver nanocrystals

  • NanobiotixX

  • Oxonica

  • Nanotherapeutics

  • NanoBio Nanoemulsions for nasal delivery to fight viruses (such as the flu and colds) and bacteria

  • BioDelivery Sciences Oral drug delivery of drugs encapuslated in a nanocrystalline structure called a cochleate

  • NanoBioMagnetics

  • Z-Medica Medical gauze containing aluminosilicate nanoparticles which help bood clot faster in open wounds.


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  • ()120


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a b: [Nature] Whitesides 442 368-373 2006


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  • IP+CRO+VC


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  • , 80

  • 50


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  • A case study of lean drug discovery: fromproject driven research to innovationstudios and process factories. Fredrik Ullman and Roman Boutellier. Drug Discovery Today Volume 13, Numbers 11/12 June 2008.

  • The impact of systems approaches on biological problems in drug discovery. Hood, L., Perlmutter, R.M.. Nat. Biotechnol. 22 (10),2004.

  • A new approach for drug discovery from glycobiology and phage-displayed peptide library technology. Takao Taki et.al. Biochimica et Biophysica Acta 1780 (2008) 497503.

  • A roadmap for drug discovery and its translation to small molecule agents in clinical development for tuberculosis treatment. H.D. Hollis Showalter, William A. Denny. Tuberculosis (2008) 88 Suppl. 1, S3-S17.

  • Application of LC/MS and related techniques to high-throughput drug discovery. Alfonso Espada. Et.al. Drug Discovery Today Volume 13, Numbers 9/10 May 2008


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