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Journey to Transplant: How Patients Facing Organ Failure Get on the Transplant Waiting List. Christine Lee, RN, BSN, CCTC Leeanne Shinn, RN UCLA Kidney and Pancreas Transplant Program. “How To Be”. Being in Action! The Answers Are In the Room “Report out” on Questions to Run-on: Scribe

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Journey to transplant how patients facing organ failure get on the transplant waiting list l.jpg

Journey to Transplant:How Patients Facing Organ Failure Get on the Transplant Waiting List

Christine Lee, RN, BSN, CCTC

Leeanne Shinn, RN

UCLA Kidney and Pancreas Transplant Program


How to be l.jpg
“How To Be”

  • Being in Action!

  • The Answers Are In the Room

  • “Report out” on Questions to Run-on:

    • Scribe

    • Spokesperson

  • All Teach / All Learn


Question to run on l.jpg
Question to Run on?

  • What can you do to educate your patients or community on the Journey to Transplant?


Introductions l.jpg
Introductions

  • Christine Lee

  • Leeanne Shinn


Objectives l.jpg
Objectives

  • Understand the referral, evaluation and listing process for organ transplant – kidney transplantation

  • Provide overview of the national wait list and review various deceased donor options

  • Discuss living donor transplant options


Treatment options l.jpg
Treatment Options

  • Heart/Lung/Liver failure: Organ transplant

    • Heart - LVAD as bridge to transplant

  • End stage renal disease (ESRD):

    • Dialysis

    • Kidney Transplant

  • Type 1 diabetes:

    • Insulin therapy

    • Pancreas alone (PA), kidney/pancreas transplant (SPK)


What is the goal of kidney transplant l.jpg
What is the goal of kidney transplant?

  • Freedom from dialysis

  • Better quality of life

  • Prolongs life compared to dialysis

  • To maximize survival


Slide8 l.jpg

Fig. 1. Overall unadjusted actuarial survival probabilities for transplanted recipients and haemodialysis patients

Mazzuchi, N. et al. Nephrol. Dial. Transplant. 1999 14:2849-2854; doi:10.1093/ndt/14.12.2849


Kidney transplant l.jpg
Kidney Transplant

  • Cons:

    • Not for everyone: compliance, health

    • Long wait time due to organ shortage

    • Require strict adherence to daily medications

    • Transplant medications for life


Referral process l.jpg
Referral Process

  • For kidney transplant - Referral made by physician, dialysis social worker, insurance case manager or patient

  • Find a local transplant program

  • Necessary documents:

    • H&P, Social worker note, most recent lab, cardiac tests, imaging studies, ABO

    • Medicare Entitlement Form (2728 form)

  • Schedule an appointment with the transplant team for evaluation


Selecting a transplant program l.jpg
Selecting a Transplant Program

  • The experience of the transplant team

  • Insurance coverage

  • Geographical proximity to the program

    • The travel time to the transplant center is important when patient is waiting for an organ and is a key factor considered in organ distribution.

  • The quality and availability of pre- and post-transplant services.

  • Availability of friends and family for assistance


Evaluation process l.jpg
Evaluation Process

  • Patient Education Orientation

  • Consultation with the transplant team

    • Transplant Physician

    • Surgeon

    • Transplant Nurse Coordinator

    • Social Worker

    • Dietician


Evaluation process14 l.jpg
Evaluation Process

  • Other consultation as needed

    • Cardiology, Hepatology, Infectious Disease, Psychiatry, Hematology, Dermatology, Oncology, etc

  • Pending tests

    • Lab: Blood type x2, HLA, PRA, serology

    • Cardiac tests: EKG, Stress test, Echocardiogram, Coronary angiogram

    • Radiology: CXR, renal/abdominal ultrasound, CT scan, MRI

    • Screening tests: PSA, pap smear, mammogram, colonoscopy


Patient selection criteria l.jpg
Patient Selection Criteria

  • Must be accepted as a candidate before listing

  • Selection Criteria

    • In general, all end-stage renal failure patients who, after having been informed of the risks of the transplant surgery and the inevitable chronic immunosuppressive therapy, still express a clear desire for this modality of treatment, will be accepted as candidates for evaluation.

  • Exclusion criteria

    • Presence of disseminated or recent malignancy

    • Active infection

    • Severe coronary artery disease and/or peripheral vascular disease

    • Underlying disease states such as multiple myeloma, scleroderma, oxalosis, sickle-cell anemia

    • Serious psychosocial problems

    • Squamous cell skin cancer

    • Renal cell carcinomas

    • BMI > 35

    • Partial insurance coverage

    • Patients that are wheelchair bound, require oxygen, or are severely disabled

    • Patients who are unwilling to accept blood transfusions under any circumstances while taking anticoagulations


Patient selection criteria16 l.jpg
Patient Selection Criteria

  • After completion of the workup, Selection Committee will review the case

  • The Committee is made up of Transplant Nephrologists, Surgeons, Nurse Coordinators, Social workers, dietician, pharmacist and other consultants

  • Once decision is made, the patient and physician will be notified in writing


Listing process l.jpg
Listing Process

  • Medical clearance by the Selection Committee

  • Financial clearance

  • Eligibility for wait time accrual

    • On maintenance dialysis

    • GFR 20 or less

  • Notification within 10 days to the patient, physician and dialysis social worker


Unos wait list l.jpg
UNOS Wait List

  • National Wait List - United Network for Organ Sharing (UNOS)

  • 107,337 patients are waiting for all organs

  • 84,000+ patients are waiting for kidney transplant


U s waiting list candidates by organs l.jpg
U.S. Waiting List Candidates by Organs

  • Based on current OPTN data as reported on May 7, 2010. Data subject to change based on future data submission or correction.


Unos wait list20 l.jpg
UNOS Wait List

  • About 16,000 transplants per year

    • 6,000 living donor transplant (doubled over 15 yrs)

    • 10,000 deceased donor

  • California Wait List

    • 16,250+ patients are waiting for kidney

    • Average wait time: 7 to 10 years


Allocation strategies l.jpg
Allocation Strategies

  • Dialysis Wait Time:

    • wait time starts as initial dialysis start date

  • Dual organ transplant

    • kidney/pancreas

    • Liver/Kidney

    • Heart/Kidney

  • Multiple listing


Is there a way to reduce the waiting time l.jpg
Is there a way to reduce the waiting time?

  • Expanded Criteria Donor (ECD) kidney

    • A kidney from a donor age over 60 years or over age 50 with a history of HTN, cause of death due to CVA, or a terminal creatinine greater than 1.5 mg/d

  • Hepatitis C list

    • Only for the patients with hepatitis C

  • Donation after cardiac death (DCD)

    • A kidney from a donor who was declared dead based on a lack of a heartbeat.

    • These kidneys are less likely to function immediately & may have a greater risk of rejection

  • The Centers for Disease Control (CDC) increased risk

    • Higher risk for the transmission of viral disease including HIV & Hepatitis

  • Donation Point

  • Living Donor Transplant


Living donor transplant options l.jpg

Living Donor Transplant Options

Compatible Recipient-Donor pairs

Desensitization Protocols

Blood Type incompatible

Kidney Exchange Program

AKA Paired Exchange or Chain Transplant


Living donation l.jpg
Living Donation

  • Related vs. Unrelated

  • Requirements

    • Age 18 ~ 65

    • Health Concerns (diabetes, high blood pressure, cancer, hepatitis, weight issue)

    • Lifestyle: substance abuse


Blood type compatibility chart l.jpg
Blood type compatibility chart

Candidate’s Blood Type

O

A

B

AB

Donor’s Blood Type

O

A or O

B or O

A, B, AB or O


Compatible recip donor pairs l.jpg
Compatible Recip-Donor Pairs

  • Blood types are compatible

  • Cross match testing indicates low risk of early rejection

  • Donor can donate directly to recipient


Slide30 l.jpg
But…

What if the donor and the recipient

are not compatible?


Slide31 l.jpg

  • 35% of any two people will be blood type incompatible

  • 30 % of patients needing a kidney transplant will be sensitized because of previous transplants, pregnancies or transfusions


  • Desensitization l.jpg
    Desensitization are excluded due to incompatible blood type and positive cross match

    • Advantages include increasing the donor pool and the friend or love one can donate to the intended recipient

    • Disadvantages include cost which averages approximately $30,000

    • Decreased patient survival (5yr 87% vs. 94%) AJT 2004

    • Unpredictable rates of accelerated rejection

    • Decreased graft survival (1yr. 84% vs. 96% ) AJT 2004

    • Decreased 5 yr. graft survival (69% vs. 81%) AJT 2009


    Blood type incompatible l.jpg
    Blood Type Incompatible are excluded due to incompatible blood type and positive cross match

    • Living donor has different blood type

    • No other donor available

    • Requires analysis of antibody levels

    • Insurance authorization for treatment

    • Pre-operative treatment protocol over several weeks to achieve safe window for transplantation with your living donor


    Slide34 l.jpg
    ABOi are excluded due to incompatible blood type and positive cross match

    • Molecules present or absent on blood cells determine blood type

    • When blood types are mixed, these molecules act as antigens that trigger ABO incompatibility reaction

    • Preconditioning is done to cleanse the blood of these circulating antibodies and depends on blood type and amount of antibodies present


    Aboi therapies l.jpg
    ABOi Therapies are excluded due to incompatible blood type and positive cross match

    • Plasmapheresis- remove antibodies

    • Immunoglobulin-decrease antibodies which are destructive to the graft

    • Splenectomy

    • Anti-CD20 Antibody (rituximab)- depletes CD20 protein which is found on the wall of most B cells


    Paired donation l.jpg
    Paired Donation are excluded due to incompatible blood type and positive cross match

    • Initially slow to take off because 1984 NOTA “unlawful to acquire organ in exchange for valuable consideration”

    • 2007 Senate bill “valuable consideration does not apply to paired donation”


    Donor exchange l.jpg
    Donor Exchange are excluded due to incompatible blood type and positive cross match

    • Recipient/donor pair have incompatible blood types

    • Other donor/recipient pair have incompatible blood types

    • Donors evaluated/accepted for donation

    • Donor/recipient pairs “exchange” donor kidneys

    • Exchange is anonymous until after surgery


    Paired donor exchange l.jpg

    Pair #1 are excluded due to incompatible blood type and positive cross match

    Recip blood type = A

    Donor blood type = B

    B to A is not compatible

    Pair #2

    Recip blood type = B

    Donor blood type = A

    A to B is not compatible

    Paired donor exchange


    Paired donor exchange39 l.jpg
    Paired Donor Exchange are excluded due to incompatible blood type and positive cross match

    Pair #1 Pair #2

    Recipient = A Recipient = B

    Donor = B Donor = A

    Blood-type incompatible Recip/Donor pairs

    exchange blood-type compatible kidneys


    Down side of paired donation l.jpg
    Down Side of Paired Donation are excluded due to incompatible blood type and positive cross match

    • If one living donor backs out then the other pair is disadvantaged

    • Requires simultaneous O.R. start


    Donor exchange chains l.jpg
    Donor Exchange “Chains” are excluded due to incompatible blood type and positive cross match

    • Participation of multiple pairs of donors and recipients

    • Usually started by a non-directed or “altruistic”

    • One donor is “left over” to begin a new section of the chain


    Donor chains l.jpg
    Donor Chains are excluded due to incompatible blood type and positive cross match

    • Living donor can donate local to where they live

    • Kidneys are shipped using established OPO protocols on commercial flights

    • Do not need simultaneous O.R. start times


    Donor chains44 l.jpg
    Donor Chains are excluded due to incompatible blood type and positive cross match

    • Very time intensive, high work load for low yield

    • Only about 120 done to date

    • Potential for 1,000 -2,000 additional kidney transplants per year

    • If there is a delay in donation, donor may back out


    In short there are new options l.jpg
    In short, there are new options are excluded due to incompatible blood type and positive cross match

    • “Standard” living donor transplant

    • Highly-sensitized

    • Blood-type incompatible

    • Paired or triple exchange

    • Donor exchange “chains”


    Conclusion l.jpg
    Conclusion are excluded due to incompatible blood type and positive cross match

    • Timely referral to transplant center

    • Communication and collaboration between the referring physician, patient, dialysis unit and the transplant team are the key

    • Advances in living donation are providing patients with more opportunities for transplant


    Question to run on47 l.jpg
    Question to Run on? are excluded due to incompatible blood type and positive cross match

    • What can you do to educate your patients or community on the Journey to Transplant?

    • 3 minutes to work at your tables and report back, Go!


    Transition to breakout session 2 l.jpg
    Transition to are excluded due to incompatible blood type and positive cross matchBreakout Session #2

    Next Breakout Session starts at 11:30

    Please see your agenda for specific room locations

    Enjoy the Learning!


    Journey to transplant how patients facing organ failure get on the transplant waiting list49 l.jpg

    Journey to Transplant: are excluded due to incompatible blood type and positive cross matchHow Patients Facing Organ Failure Get on the Transplant Waiting List

    Christine Lee, RN, BSN, CCTC

    Leeanne Shinn, RN

    UCLA Kidney and Pancreas Transplant Program


    How to be50 l.jpg
    “How To Be” are excluded due to incompatible blood type and positive cross match

    • Being in Action!

    • The Answers Are In the Room

    • “Report out” on Questions to Run-on:

      • Scribe

      • Spokesperson

    • All Teach / All Learn


    Question to run on51 l.jpg
    Question to Run on? are excluded due to incompatible blood type and positive cross match

    • What can you do to educate your patients or community on the Journey to Transplant?


    Introductions52 l.jpg
    Introductions are excluded due to incompatible blood type and positive cross match

    • Christine Lee

    • Leeanne Shinn


    Objectives53 l.jpg
    Objectives are excluded due to incompatible blood type and positive cross match

    • Understand the referral, evaluation and listing process for organ transplant – kidney transplantation

    • Provide overview of the national wait list and review various deceased donor options

    • Discuss living donor transplant options


    Treatment options54 l.jpg
    Treatment Options are excluded due to incompatible blood type and positive cross match

    • Heart/Lung/Liver failure: Organ transplant

      • Heart - LVAD as bridge to transplant

    • End stage renal disease (ESRD):

      • Dialysis

      • Kidney Transplant

    • Type 1 diabetes:

      • Insulin therapy

      • Pancreas alone (PA), kidney/pancreas transplant (SPK)


    What is the goal of kidney transplant55 l.jpg
    What is the goal of kidney transplant? are excluded due to incompatible blood type and positive cross match

    • Freedom from dialysis

    • Better quality of life

    • Prolongs life compared to dialysis

    • To maximize survival


    Slide56 l.jpg

    Fig. 1. are excluded due to incompatible blood type and positive cross match Overall unadjusted actuarial survival probabilities for transplanted recipients and haemodialysis patients

    Mazzuchi, N. et al. Nephrol. Dial. Transplant. 1999 14:2849-2854; doi:10.1093/ndt/14.12.2849


    Kidney transplant57 l.jpg
    Kidney Transplant are excluded due to incompatible blood type and positive cross match

    • Cons:

      • Not for everyone: compliance, health

      • Long wait time due to organ shortage

      • Require strict adherence to daily medications

      • Transplant medications for life


    Referral process58 l.jpg
    Referral Process are excluded due to incompatible blood type and positive cross match

    • For kidney transplant - Referral made by physician, dialysis social worker, insurance case manager or patient

    • Find a local transplant program

    • Necessary documents:

      • H&P, Social worker note, most recent lab, cardiac tests, imaging studies, ABO

      • Medicare Entitlement Form (2728 form)

    • Schedule an appointment with the transplant team for evaluation


    Selecting a transplant program59 l.jpg
    Selecting a Transplant Program are excluded due to incompatible blood type and positive cross match

    • The experience of the transplant team

    • Insurance coverage

    • Geographical proximity to the program

      • The travel time to the transplant center is important when patient is waiting for an organ and is a key factor considered in organ distribution.

    • The quality and availability of pre- and post-transplant services.

    • Availability of friends and family for assistance


    Evaluation process60 l.jpg
    Evaluation Process are excluded due to incompatible blood type and positive cross match

    • Patient Education Orientation

    • Consultation with the transplant team

      • Transplant Physician

      • Surgeon

      • Transplant Nurse Coordinator

      • Social Worker

      • Dietician


    Evaluation process62 l.jpg
    Evaluation Process are excluded due to incompatible blood type and positive cross match

    • Other consultation as needed

      • Cardiology, Hepatology, Infectious Disease, Psychiatry, Hematology, Dermatology, Oncology, etc

    • Pending tests

      • Lab: Blood type x2, HLA, PRA, serology

      • Cardiac tests: EKG, Stress test, Echocardiogram, Coronary angiogram

      • Radiology: CXR, renal/abdominal ultrasound, CT scan, MRI

      • Screening tests: PSA, pap smear, mammogram, colonoscopy


    Patient selection criteria63 l.jpg
    Patient Selection Criteria are excluded due to incompatible blood type and positive cross match

    • Must be accepted as a candidate before listing

    • Selection Criteria

      • In general, all end-stage renal failure patients who, after having been informed of the risks of the transplant surgery and the inevitable chronic immunosuppressive therapy, still express a clear desire for this modality of treatment, will be accepted as candidates for evaluation.

    • Exclusion criteria

      • Presence of disseminated or recent malignancy

      • Active infection

      • Severe coronary artery disease and/or peripheral vascular disease

      • Underlying disease states such as multiple myeloma, scleroderma, oxalosis, sickle-cell anemia

      • Serious psychosocial problems

      • Squamous cell skin cancer

      • Renal cell carcinomas

      • BMI > 35

      • Partial insurance coverage

      • Patients that are wheelchair bound, require oxygen, or are severely disabled

      • Patients who are unwilling to accept blood transfusions under any circumstances while taking anticoagulations


    Patient selection criteria64 l.jpg
    Patient Selection Criteria are excluded due to incompatible blood type and positive cross match

    • After completion of the workup, Selection Committee will review the case

    • The Committee is made up of Transplant Nephrologists, Surgeons, Nurse Coordinators, Social workers, dietician, pharmacist and other consultants

    • Once decision is made, the patient and physician will be notified in writing


    Listing process65 l.jpg
    Listing Process are excluded due to incompatible blood type and positive cross match

    • Medical clearance by the Selection Committee

    • Financial clearance

    • Eligibility for wait time accrual

      • On maintenance dialysis

      • GFR 20 or less

    • Notification within 10 days to the patient, physician and dialysis social worker


    Unos wait list66 l.jpg
    UNOS Wait List are excluded due to incompatible blood type and positive cross match

    • National Wait List - United Network for Organ Sharing (UNOS)

    • 107,337 patients are waiting for all organs

    • 84,000+ patients are waiting for kidney transplant


    U s waiting list candidates by organs67 l.jpg
    U.S. Waiting List Candidates by Organs are excluded due to incompatible blood type and positive cross match

    • Based on current OPTN data as reported on May 7, 2010. Data subject to change based on future data submission or correction.


    Unos wait list68 l.jpg
    UNOS Wait List are excluded due to incompatible blood type and positive cross match

    • About 16,000 transplants per year

      • 6,000 living donor transplant (doubled over 15 yrs)

      • 10,000 deceased donor

    • California Wait List

      • 16,250+ patients are waiting for kidney

      • Average wait time: 7 to 10 years


    Allocation strategies71 l.jpg
    Allocation Strategies are excluded due to incompatible blood type and positive cross match

    • Dialysis Wait Time:

      • wait time starts as initial dialysis start date

    • Dual organ transplant

      • kidney/pancreas

      • Liver/Kidney

      • Heart/Kidney

    • Multiple listing


    Is there a way to reduce the waiting time72 l.jpg
    Is there a way to reduce the waiting time? are excluded due to incompatible blood type and positive cross match

    • Expanded Criteria Donor (ECD) kidney

      • A kidney from a donor age over 60 years or over age 50 with a history of HTN, cause of death due to CVA, or a terminal creatinine greater than 1.5 mg/d

    • Hepatitis C list

      • Only for the patients with hepatitis C

    • Donation after cardiac death (DCD)

      • A kidney from a donor who was declared dead based on a lack of a heartbeat.

      • These kidneys are less likely to function immediately & may have a greater risk of rejection

    • The Centers for Disease Control (CDC) increased risk

      • Higher risk for the transmission of viral disease including HIV & Hepatitis

    • Donation Point

    • Living Donor Transplant


    Living donor transplant options73 l.jpg

    Living Donor Transplant Options are excluded due to incompatible blood type and positive cross match

    Compatible Recipient-Donor pairs

    Desensitization Protocols

    Blood Type incompatible

    Kidney Exchange Program

    AKA Paired Exchange or Chain Transplant


    Living donation75 l.jpg
    Living Donation are excluded due to incompatible blood type and positive cross match

    • Related vs. Unrelated

    • Requirements

      • Age 18 ~ 65

      • Health Concerns (diabetes, high blood pressure, cancer, hepatitis, weight issue)

      • Lifestyle: substance abuse


    Blood type compatibility chart76 l.jpg
    Blood type compatibility chart are excluded due to incompatible blood type and positive cross match

    Candidate’s Blood Type

    O

    A

    B

    AB

    Donor’s Blood Type

    O

    A or O

    B or O

    A, B, AB or O


    Compatible recip donor pairs77 l.jpg
    Compatible Recip-Donor Pairs are excluded due to incompatible blood type and positive cross match

    • Blood types are compatible

    • Cross match testing indicates low risk of early rejection

    • Donor can donate directly to recipient


    Slide78 l.jpg
    But… are excluded due to incompatible blood type and positive cross match

    What if the donor and the recipient

    are not compatible?


    Slide79 l.jpg

  • 35% of any two people will be blood type incompatible

  • 30 % of patients needing a kidney transplant will be sensitized because of previous transplants, pregnancies or transfusions


  • Desensitization80 l.jpg
    Desensitization are excluded due to incompatible blood type and positive cross match

    • Advantages include increasing the donor pool and the friend or love one can donate to the intended recipient

    • Disadvantages include cost which averages approximately $30,000

    • Decreased patient survival (5yr 87% vs. 94%) AJT 2004

    • Unpredictable rates of accelerated rejection

    • Decreased graft survival (1yr. 84% vs. 96% ) AJT 2004

    • Decreased 5 yr. graft survival (69% vs. 81%) AJT 2009


    Blood type incompatible81 l.jpg
    Blood Type Incompatible are excluded due to incompatible blood type and positive cross match

    • Living donor has different blood type

    • No other donor available

    • Requires analysis of antibody levels

    • Insurance authorization for treatment

    • Pre-operative treatment protocol over several weeks to achieve safe window for transplantation with your living donor


    Slide82 l.jpg
    ABOi are excluded due to incompatible blood type and positive cross match

    • Molecules present or absent on blood cells determine blood type

    • When blood types are mixed, these molecules act as antigens that trigger ABO incompatibility reaction

    • Preconditioning is done to cleanse the blood of these circulating antibodies and depends on blood type and amount of antibodies present


    Aboi therapies83 l.jpg
    ABOi Therapies are excluded due to incompatible blood type and positive cross match

    • Plasmapheresis- remove antibodies

    • Immunoglobulin-decrease antibodies which are destructive to the graft

    • Splenectomy

    • Anti-CD20 Antibody (rituximab)- depletes CD20 protein which is found on the wall of most B cells


    Paired donation84 l.jpg
    Paired Donation are excluded due to incompatible blood type and positive cross match

    • Initially slow to take off because 1984 NOTA “unlawful to acquire organ in exchange for valuable consideration”

    • 2007 Senate bill “valuable consideration does not apply to paired donation”


    Donor exchange85 l.jpg
    Donor Exchange are excluded due to incompatible blood type and positive cross match

    • Recipient/donor pair have incompatible blood types

    • Other donor/recipient pair have incompatible blood types

    • Donors evaluated/accepted for donation

    • Donor/recipient pairs “exchange” donor kidneys

    • Exchange is anonymous until after surgery


    Paired donor exchange86 l.jpg

    Pair #1 are excluded due to incompatible blood type and positive cross match

    Recip blood type = A

    Donor blood type = B

    B to A is not compatible

    Pair #2

    Recip blood type = B

    Donor blood type = A

    A to B is not compatible

    Paired donor exchange


    Paired donor exchange87 l.jpg
    Paired Donor Exchange are excluded due to incompatible blood type and positive cross match

    Pair #1 Pair #2

    Recipient = A Recipient = B

    Donor = B Donor = A

    Blood-type incompatible Recip/Donor pairs

    exchange blood-type compatible kidneys


    Down side of paired donation88 l.jpg
    Down Side of Paired Donation are excluded due to incompatible blood type and positive cross match

    • If one living donor backs out then the other pair is disadvantaged

    • Requires simultaneous O.R. start


    Donor exchange chains89 l.jpg
    Donor Exchange “Chains” are excluded due to incompatible blood type and positive cross match

    • Participation of multiple pairs of donors and recipients

    • Usually started by a non-directed or “altruistic”

    • One donor is “left over” to begin a new section of the chain


    Donor chains90 l.jpg
    Donor Chains are excluded due to incompatible blood type and positive cross match

    • Living donor can donate local to where they live

    • Kidneys are shipped using established OPO protocols on commercial flights

    • Do not need simultaneous O.R. start times


    Donor chains92 l.jpg
    Donor Chains are excluded due to incompatible blood type and positive cross match

    • Very time intensive, high work load for low yield

    • Only about 120 done to date

    • Potential for 1,000 -2,000 additional kidney transplants per year

    • If there is a delay in donation, donor may back out


    In short there are new options93 l.jpg
    In short, there are new options are excluded due to incompatible blood type and positive cross match

    • “Standard” living donor transplant

    • Highly-sensitized

    • Blood-type incompatible

    • Paired or triple exchange

    • Donor exchange “chains”


    Conclusion94 l.jpg
    Conclusion are excluded due to incompatible blood type and positive cross match

    • Timely referral to transplant center

    • Communication and collaboration between the referring physician, patient, dialysis unit and the transplant team are the key

    • Advances in living donation are providing patients with more opportunities for transplant


    Question to run on95 l.jpg
    Question to Run on? are excluded due to incompatible blood type and positive cross match

    • What can you do to educate your patients or community on the Journey to Transplant?

    • 3 minutes to work at your tables and report back, Go!


    Transition to lunch l.jpg
    Transition to Lunch are excluded due to incompatible blood type and positive cross match

    Lunch is from 12:30 – 1:30

    In the Crystal Ballroom, on the main level of the hotel

    Open seating

    Bon Appétit!


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