biologically important heterocycles
Download
Skip this Video
Download Presentation
Biologically important heterocycles

Loading in 2 Seconds...

play fullscreen
1 / 12

Biologically important heterocycles - PowerPoint PPT Presentation


  • 107 Views
  • Uploaded on

Biologically important heterocycles. Alice Skoumalová. Heme complexed with protein in hemoglobin 4 pyrrole rings coordinated with Fe 2+ side chains: methyl, propionyl, vinyl carries oxygen to the tissues. Bilirubin degradation product of heme (cleavage and reduction)

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' Biologically important heterocycles' - padma


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
slide5

Heme

  • complexed with protein in hemoglobin
  • 4 pyrrole rings coordinated with Fe2+
  • side chains: methyl, propionyl, vinyl
  • carries oxygen to the tissues
  • Bilirubin
  • degradation product of heme (cleavage and reduction)
  • excreted in the bile
  • jaundice
slide6

Tryptophan

  • an amino acid (serotonin and melatonin precursor)
  • Serotonin
  • a neurotransmitter (mood control)
  • many antidepressant drugs increase the level of serotonin in the brain
  • Melatonin
  • a hormone (produced in response to the light-dark cycle → regulates circadian rhythms)
  • an antioxidant → protective effects
slide7

Histidine

  • an amino acid (histamine precursor)
  • Histamine
  • a neurotransmitter (the major mediator of the allergic response → vasodilation, bronchoconstriction)
  • antihistamines (block histamine from binding to its receptor)
  • Biotin (vit. H)
  • in liver, egg yolk, yeast products, legumes, nuts
  • function: carboxylation (the coenzyme of the carboxylases)
slide8

Thiamine (vit. B1)

  • contains two heterocyclic rings
  • in grain, yeast products, pork
  • its deficiency (beriberi → neurological disturbances, cardiac insufficiency, and muscular atrophy)
  • function: oxidative decarboxylation
  • Tocopherol (vit. E)
  • in cereals, liver, eggs, seed oil
  • function: antioxidant in membranes
slide9

Nicotinamide (niacin)

  • in meat, yeast products, fruit, vegetables
  • its deficiency (pellagra → skin damage, digestive disturbances, depression)
  • function: in the coenzymes NADH and NADPH (dehydrogenases)

NAD+

NADH

  • Pyridoxal (vit. B6)
  • in meat, vegetables, grain products
  • function: the coenzyme in the amino acid metabolism
slide10

Nucleotide bases derived from pyrimidine

  • in nucleic acids

Cytosine

Uracil

Thymine

(in both RNA and DNA)

(in RNA)

(in DNA)

  • a nucleic acid base is N-glycosidically linked to ribose or 2-deoxyribose
  • the sugar is esterified with phosphoric acid
slide11

Nucleotide bases derived from purine

  • in nucleic acids , ATP, NADP, FAD, CoA
  • degradation of purine nucleotides → uric acid (excreted)

Guanine

Adenine

Uric acid

(in both RNA and DNA)

(in both RNA and DNA)

anhydride bonds

an ester bond

  • the most important form of chemical energy in cells

ATP

slide12

Folic acid

  • in fresh green vegetables, liver
  • its deficiency (megaloblastic anemia)
  • function: coenzyme in C1 metabolism (nucleotide biosynthesis)
  • Riboflavin
  • in milk, eggs
  • function: in the coenzymes FMN and FAD (oxidation and reduction)

riboflavin

FAD

FADH2

ad