DEFINITION:. Psychopharmacology is the gold standard in treatment of neurobiological illnesses, more and more of which are found to have genetic underpinnings.. CLASSIFICATION:. 1-Antianxiety and sedative-hypnotic Drugs2-Antidepressant Drugs3-Antipsychotic Drugs5-Mood-Stailizing Drugs. 1-Antianxiety and sedative-hypnotic Drugs: Benzodiazepines.
2. DEFINITION: Psychopharmacology is the gold standard in treatment of neurobiological illnesses, more and more of which are found to have genetic underpinnings.
3. CLASSIFICATION: 1-Antianxiety and sedative-hypnotic Drugs
4. 1-Antianxiety and sedative-hypnotic Drugs: Benzodiazepines
6. Sedative-hypnotic Drugs: Benzodiazepines
9. - Anxiety disorders:
Panic diorder,obessive-compulsive disorder(OCD),social phobia, generalized anxiety disoeder,posttraumatic
-selective serotonin reptake inhibitors(SSRIs)
Bulimia, premenstrual dysphoric disorder full and half cycle administration)
10. Cont. 2-Moderate evidence:
Obesity, substance abuse, impulsivity and anger associated with personality disorders, pain syndromes.
Body dysmorphic disorder,hypochondriasis,anger attacks associated with depression, attention deficit/hyperactivity disorder(ADHD)
11. Cont. -other newer antidepressant
Moderate: evidence:Trazodone:insomnia,dementia with agitation,minor sedative hypnotic with drawal
14. Nursing consideration
18. Mood-Stabilizing Drugs Target Symptoms for mood-Stabilizing drug therapy Mania
Lability with depression
Sleep disturbance (decrease sleep)
Flight of ideas
Poor concentration and memory
19. Mood-Stabilizing Drugs DRUG CLASS
20. Lithium Lithium, a naturally occurring salt, is first-line treatment for patients with acute mania and for the long term prevention of recurrent episodes. Lithium also has a role in the treatment of recurrent bipolar depression, unipolar depression, aggressive behaviors, conduct disorder and schizoaffective disorder.
21. Stabilizing Lithium Levels Common causes for an increase in lithium levels
Decrease sodium intake .
Decrease renal functioning.
Fluid and electrolyte loss, sweating, dirrhea, dehydration, fever.
Medical illness .
22. Murine EPS Drug Doses IP doses are calibrated to give 0.2 ml for a 30 g mouse Atropine: 0.5 mg/g = 15 mg IP (Mix 0.2 ml of stock solution in a total of 1 ml) Atropine stock in vial = 0.4 mg/ml
Carbamyl choline: 500 ng/g = 15 mg IP (Mix 7.5 mg into 10 ml for a x10 stock solution)
Cefazolin: 200 mg/g/day = 6 mg/day in two divided doses = 3 mg IP bid (Mix 24 mg into 1.6 ml for 8 individual doses)
Digoxin: 20 ng/g bid = 0.6 mg IP bid on Day 1 (Mix 0.2 ml of stock in a total of 10 ml). On Day 2 give 10 ng/g bid = 0.3 mg IP bid (0.1 ml IP) Digoxin stock in vial = 0.1 mg/ml
Isoproterenol: 3 ng/g = 90 ng IP (Mix 0.25 ml of x100 stock in a total of 1 ml) Isoproterenol x100 stock = 2 mg/ml
23. Cont. Propranolol: 1 mg/g = 30 mg IP (Mix 0.15 ml of stock in a total of 1 ml) Propranolol stock in vial = 1 mg/ml
IV doses are calibrated to give 0.05 ml for a 30 g mouse
Isoproterenol: 1 ng/g = 30 ng IV (Mix 0.3 ml of x100 stock in a total of 1 ml) Isoproterenol x100 stock = 2 mg/ml
Procainamide: 30 mg/g = 900 mg IV (Add 2.2 ml of procainamide stock to 10 ml for a total of 12.2 ml which gives a concentration of 18 mg/ml) Procainamide stock in vial = 100 mg/ml
Principles and practice of
GAIL W. STUART
MICHELE T. LARAIA