Thomas J. Hughes and Elaina Kenyon QA and Records Manager, and Research Scientist Experimental Toxicology Division (ETD) U.S. EPA, ORD, NHEERL, RTP, NC U.S. EPA Annual QA Meeting San Antonio, TX May 14, 2009 The Use of Secondary Data in Modeling of Biological Data PURPOSE
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QA and Records Manager,
and Research Scientist
Experimental Toxicology Division (ETD)
U.S. EPA, ORD, NHEERL, RTP, NC
U.S. EPA Annual QA Meeting
San Antonio, TX
May 14, 2009
3. Discuss other types of checklists (surveillance and QC)
4. Case studies
2. Supportive – secondary data used for models when data will be used for initial assessment or the data are from in vitro experiments.
Primary – data are supplied for individuals, and a comprehensive discussion of results and all supporting data necessary for complete reanalysis of data are provided (e.g., controls and dose response data.
Supportive – data are pooled, means and standard deviations are supplied, but supporting data are not comprehensive and all data for reanalysis are not available.
ETD Secondary Data Checklist (Handout)
4. Other checklists for secondary exist.
ETD Surveillance Checklist (Handout)
ETD Quality Control Checklist (Handout)
4. Checklist assists scientists with the QC section of the research protocol.
1. Human liver P450 cytochrome iso-enzymes and BDCM metabolism (Zhao and Allis, 2002).
3. Case Studies (UF, DDEF)