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The Future of Science Education – A National Effort Targeting Freshmen & Sophomores Tuajuanda Jordan Howard Hughes Medical Institute ASMCUE Endicott College May 30 – June 1, 2008 The Science Education Alliance Mission: To be a national resource for science education by

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The Future of Science Education –A National Effort Targeting Freshmen & Sophomores

Tuajuanda Jordan

Howard Hughes Medical Institute

ASMCUE

Endicott College

May 30 – June 1, 2008


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The Science Education Alliance

  • Mission: To be a national resource for science education by

    • Developing and providing new materials and methods to the education community

    • Assembling and supporting educator networks engaged in common activities


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The Ultimate Goal

  • Improve the production and quality of 21st-century scientists

RESEARCH

EDUCATION


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Students

National Genomics Research Initiative – What is it?

  • An authentic research experience

  • A collaborative enterprise targeting novice undergraduate scientists

  • A discovery-based genomics initiative that guides the novice from organism isolation through genome annotation

  • A partnership

Lead scientist

HHMI

Science educators

Institutions


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The National Genomics Research Initiative – What are the goals?

  • Give students experience in genomics research in a supportive and dynamic learning environment

  • Empower students and faculty

    • Process of doing science

    • Tools

    • Real data worthy of dissemination

  • Foster local and national collaborations

    • Students

    • Students and faculty

    • Faculty members


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The NGRI  PGRI

  • Why bacteriophage?

    • Plentifula

    • Highly diverse

    • Easily isolated directly from the environment

    • Relatively simple and small genomes

    • Lead scientist

      • HHMI Professor

      • Established outreach program

    • Well established techniques to

      • Isolate, propagate, purify, and visualize the phage

      • Isolate, purify, clone, and characterize the DNA

aHatfull GF, et al 2006


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The PGRI - Why underclassmen?

Freshmen / Sophomores

Early engagement in mentored research

Encounter research results in upper-level (converted) coursework

Increased #s pursuing advanced degrees and careers in biomedical science

Increased production & quality of biomedical scientists


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Send phage to sequencing center

Collect soil

Isolate, characterize, & purify phage

Isolate & purify DNA

Preliminary DNA characterization

EM

Draft assemblies to students

Finished sequences to students

Phage DNA

Raw sequences

Whole genome sequencing

Genome finishing

Jan.

Mar.

Genome sequences

GenBank submission?

Genome annotation

The PGRI – How does it work?

- Lead scientist poses the question of the year.

Part I: in situ -

Aug/Sept

Early Nov.

Part II: transition -

Nov.

Jan.

Part III: in silico

Jan.

Apr./May


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The PGRI – Roles & Responsibilities

Lead scientist

Students

Scientists

HHMI

Science educators

Institutions


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Lead Scientist

Provides scientific direction and expertise

Takes lead in data analysis and assessment of scientific significance and impact

Primary author on publications

Science Educator (Faculty)

Provides novice students

Oversees student direction

Ensures accuracy and integrity of student-generated data

Writes draft manuscript

The PGRI – Roles and Responsibilities

  • HHMI

    • Faculty training

    • Experimental methods, supplies, and resources

    • Curriculum materials

    • Community-building activities and resources

    • Assessment resources and metrics

    • Networking and dissemination venue

  • Participating institutions

    • Provide faculty with time and resources to design and implement course

    • Assist HHMI in program assessment


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Fall 2008 Cohort Institutions

Oregon State University

Hope College

University of Maryland, Baltimore County

Carnegie Mellon University

James Madison University

University of California, Santa Cruz

College of William and Mary

University of Mary Washington

Washington University at St. Louis

Spelman College

University of California, San Diego

University of Louisiana at Monroe


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Genomics Education

National Experiments


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Genomics Education

National Experiments

Harnessing the energy of a major un-tapped resource to answer questions of scientific interest


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Genomics Education

National Experiments

: The PGRI

  • A lead scientist poses a question of scientific interest

  • A national network of college freshmen work to address the question

  • Local faculty guide these novice researchers through the process of doing science

  • The novice researchers gain practical experience in microbiology, molecular biology, electron microscopy, and bioinformatics

  • HHMI provides the resources to implement and carry out the experience


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The National Genomics Research Initiative

  • Queries about the NGRI or the SEA

    • [email protected]

  • Applications

    • www.hhmi.org/sea

Reference

  • Hatfull GF, Pedulla ML, Jacobs-Sera D, Cichon PM, Foley A, et al. (2006) Exploring the Mycobacteriophage Metaproteome: Phage Genomics as an Educational Platform. PLoS Genetics2(6): e92 doi:10.1371/journal.pgen.0020092


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