Ipecac Abuse Tomas J Silber, MD, MASS Children’s National Medical Center Division of Adolescent Medicine Department of Pediatrics, GWU. Presentation for the Center for Drug Evaluation and Research Office of executive Programs, US Food and Drug Administration June 12, 2003.
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Presentation for the
Center for Drug Evaluation and Research
Office of executive Programs, US Food and Drug Administration
June 12, 2003
Abuse of ipecac syrup
Ipecac Abuse: DefinitionIpecac abuse consists of the repeated use of the syrup for the sole purpose of self-inducing emesis as a method of weight control
(Bulik CM: Eating Disorders in adolescents and young adults. Child and Adol Psychiatri Clin N Am 2002(11):201-218.)
(Fairburn CG, Beglin SJ: Studies of the epidemiology of bulimia nervosa. Am J Psychiatry 1990;147:401-408.)
*There is no data on the incidence and prevalence of the use of ipecac to self-induce vomiting.
Muscle pain and stiffness
Cardiac arrhythmiasSigns and Symptoms of Ipecac Poisoning*
Death - n=6 (4 due to ipecac abuse)
*Lee L, Karwoski C: Post-Marketing Safety Review - PID# D030159 - May, 6, 2003
*Reversible with cessation of use
Reduced ejection fraction
Electron microscopy of myocardium:
Zones of myofibrillar lysis
Irregular alignments or clumps of Z bands
(high performance liquid chromatography)