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Στατιστική διαγνωστικών δοκιμασιών PowerPoint PPT Presentation


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Στατιστική διαγνωστικών δοκιμασιών. Καμπύλη ROC. Διαγνωστικός έλεγχος. Οι ιατρικοί διαγνωστικοί έλεγχοι έχουν τρεις στόχους: Να δώσουν αξιόπιστες πληροφορίες για την κατάσταση ενός ασθενούς Να επηρεάσουν το πλάνο αντιμετώπισης της ασθένειας.

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Στατιστική διαγνωστικών δοκιμασιών

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5669211

ROC


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  • :

    • .

    • .

  • .

  • . (-).


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  • ( )

    • (..PSA, )

    • (.. -V)

    • (/, .. CRP )

  • ()

    • (/)


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  • : ;

  • PPV=TP/TP+FP

  • :

  • ;

  • NPV = TN/F+TN


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PPV=TP/TP+FP = 14/22 = 0.6464%

Prev = 15/114 = 13%

NPV = TN/F+TN = 91/92 = 0.9999%

  • Bibbo N. et al. Acta Cytol 1988


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  • Prev = 13%

  • Sens = 93%

  • Spec = 92%

  • PPV = 64%

  • NPV = 99%

  • Prev = 38%

  • Sens = 93%

  • Spec = 92%

  • PPV = 88%

  • NPV = 96%


Ppv npv

PPV & NPV


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  • :

  • Sens = TP/TP+FN

  • :

  • Spec = /FP+TN


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Sens = TP/TP+FN = 14/15 = 0.93 93%

Spec = /FP+TN = 91/99 = 0.92 92%

  • Bibbo N. et al. Acta Cytol 1988 (Book: Medical Epidemiology)


Sens spec

Sens & Spec


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: 100%

:100%


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(LR)

  • LR+

    LR+=Sens/(1-Spec) (0, )

    LR+=1

    LR+ > 1( )

  • LR-

    LR-= (1-Sens)/Spec (0, )

    LR-=1

    LR- < 1 ( )


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A I

  • = TP=0,82

  • 1-= FN=0,18

  • E= TN=0,77

  • 1-= FP=0,23

  • LR=TP/TN= 0,82/(1-0,77)=3,56


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  • SEp(1-p)/n

  • Width SE*1,96

  • E;

    • 70,6%- 93,4%

    • 69%-85%

    • 6,6%-29%

    • 15%-31%


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ROC

  • UC

  • 0.5 <AUC < 1.0

  • AUC=0.5 ( )


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