Tuberculosis in Children and Young Adults. Clydette Powell, MD, MPH USAID/Washington CCIH, May 2004. Objectives. Overview global epidemiology Review available surveillance data and epidemiologic studies Review TB and HIV association Assess data limitations
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Tuberculosis in Children and Young Adults
Clydette Powell, MD, MPH
CCIH, May 2004
WHO Report 2000
“A deterioration in the control of TB thus immediately hurts the youngest generation” (Rieder, 1997)
Rieder H. Anales Nestle, 1997
Effect of HIV?
Per 100,000 population
Childhood TB diagnosed by:
Effect of HIV?
Risk factors : infection to disease
Short incubation period
More difficult to diagnose
Tuberculous Infection Among Children by Type of
Contact and Bacteriologic Status of Index Case,
British Columbia and Saskatchewan, 1966-1971
Grzybowski S, et al. Bull Int Union Tuberc 1975;50:90-106
Harries AD et al. Int J Tuberc Lung Dis. 2002; 6: 424-31.
< 15 years
Berman et al. Tubercle. 1992; 73: 349-55.
Colditz GA et al. JAMA 1994; 271: 698-702.
Relationship between TB and HIV
What about children?
Estimated TB incidence
(per 100 000 population)
HIV prevalence adults 15- 49 years
Clinical and immunopathological course of HIV associated TB