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LIFE CYCLES OF VIRUSES. VIRUSES CAN EXHIBIT TWO TYPES OF LIFE CYCLES. 1. THE LYTIC CYCLE 2. THE LYSOGENIC CYCLE SOME VIRUSES EXHIBIT ONLY THE LYTIC CYLE. SOME VIRUSES CAN EXHIBIT BOTH LYTIC AND LYSOGENIC CYCLES. The Lysogenic Cycle.

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LIFE CYCLES OF VIRUSES

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LIFE CYCLES OF VIRUSES


  • VIRUSES CAN EXHIBIT TWO TYPES OF LIFE CYCLES.

    1. THE LYTIC CYCLE

    2. THE LYSOGENIC CYCLE

  • SOME VIRUSES EXHIBIT ONLY THE LYTIC CYLE.

  • SOME VIRUSES CAN EXHIBIT BOTH LYTIC AND LYSOGENIC CYCLES.


The Lysogenic Cycle


VARIETY OF ANIMAL VIRAL INFECTIONS - LYTIC OR LYSOGENIC VIRUSES?


TRANSDUCTION


HOW ANIMAL VIRUSES ENTER ANIMAL CELLS


HOW ARE ANIMAL VIRUSES CULTURED IN THE LABORATORY

  • CLASSIFICATION OF MEDIA

  • LIVING MEDIA AND NON-LIVING MEDIA


CELL CULTURE


HOW ARE CELL CULTURES GROWN?


  • CYTOPATHIC EFFECT - CPE

  • SOME VIRUSES, WHEN THEY INFECT A CELL, CHANGE THE MORPHOLOGY OF THE CELL IN VERY SPECIFIC WAYS.


ANTIVIRAL AGENTS

GENERALIZATIONS

AMANTADINE

TAMIFLU (RELENZA)

A VARIETY OF NUCLEOSIDE ANALOGS

ACYCLOVIR, AZT, 3TC, DDI, DDC

PROTEASE INHIBITORS

INTERFERONS


AMANTADINE


AVARIETY OF NUCLEOSIDE ANALOGS


PROTEASE INHIBITORS AND INTERFERONS


HEPATITIS VIRUSES

HAV – 50%

HBV – 30%

HCV – 20%

MODE OF TRANSMISSION

CHRONICITY - CHRONIC OR ACUTE INFECTION

TREATMENT/VACCINE


UNCONVENTIONAL INFECTIVE AGENTS

VIROIDS - 1967

SMALL CIRCULAR MOLECULES OF SINGLE STRANDED RNA

COMPOSED OF 359 NUCLEOTIDES

BEST STUDIED VIROID CAUSES DISEASE IN POTATOES

10X SMALLER THAN SMALLEST KNOWN VIRUS


PRIONS

INFECTIOUS SELF REPLICATING PROTEINS

COMPOSED OF ABOUT 250 AMINO ACIDS

100X SMALLER THAN THE SMALLEST KNOWN VIRUS

CAUSATIVE AGENT OF MAD COW DISEASE (BOVINE SPONGIFORM ENCEPHALOPATHY) AND TWO HUMAN DISEASES

CREUTZFELDT - JAKOB DISEASE (CJD)

KURU


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