Research opportunities in the department of otolaryngology head and neck surgery
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Research Opportunities in the Department of Otolaryngology-Head and Neck Surgery. Kibwei A. McKinney, MD Yu-Tung Wong, MD Scott Shadfar , MD. Outline. Funding opportunities Subspecialty Areas Clinical/Research Faculty Areas of Interest Examples. ENT Residency Application.

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Research Opportunities in the Department of Otolaryngology-Head and Neck Surgery

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Research opportunities in the department of otolaryngology head and neck surgery

Research Opportunities in the Department of Otolaryngology-Head and Neck Surgery

Kibwei A. McKinney, MD

Yu-Tung Wong, MD

Scott Shadfar, MD


Outline

Outline

  • Funding opportunities

  • Subspecialty Areas

  • Clinical/Research Faculty

    • Areas of Interest

  • Examples


Ent residency application

ENT Residency Application

  • Step 1 USMLE Score

  • Medical School GPA

  • Extra-curricular Activities

  • Research


Duration of research

Duration of Research

  • 2 months – Projects completed during the summerin between the 1st and 2nd yr

  • 1 year – Projects completed during a year off in between the 3rd and 4th years of medical school


Grants funding opportunities

Grants/Funding Opportunities

  • 2 months – Research Training in Otolaryngology Program (8-12 weeks)

    • Application online at Carolina Medical Student Research Program website: www.med.unc.edu/rschofc/omsr/cmsrp.htm

    • Due Feb. 8th, 2010

  • 1 year - https://cgibd.med.unc.edu/omsr/oppor.php

    • Research Training in Otolaryngology

    • Doris Duke Clinical Fellowship Program

    • American Otologic Society Research Fellowship (T32)

    • Howard Hughes Medical Institute Training Fellowship

    • Holderness Fellowship (4 Yearly)


Otolaryngology subspecialty areas

Otolaryngology Subspecialty Areas

  • Head and Neck Surgery (Cancer Research)

  • Otology/Neurotology

  • Facial Plastic Surgery

  • Rhinology/Sinus Surgery

  • Laryngology

  • Anterior Skull Base Surgery

  • Pediatric Otolaryngology


Head and neck surgery

Head and Neck Surgery

  • Marion Couch, MD, Ph. D. – Cancer Cachexia

  • Neil Hayes, MD, MPH – Molecular pathogenesis of head and neck Cancers

  • Mark Weissler, MD – Outcomes Research in Head and Neck Cancer

  • Carol Shores, MD – EBV related Head and Neck Cancer in Lilongwe, Malawi


Cancer cachexia

Cancer Cachexia

  • Loss of weight, muscle atrophy, catabolism associated with end-stage cancer

  • Significant cause of morbidity


Cancer cachexia1

Cancer Cachexia

  • Historically thought to be mediated by increased energy expenditure by rapidly proliferating cancer cells

  • Increasing body of evidence attributing cachexia to pathophysiologic mechanisms at the cellular level

  • NF-κB – ubiquitous protein complex that controls DNA replication

    • When constitutively active, proper regulation does not occurcellularproliferationtumor

    • AlsoInflammation (possibly leading to cachexia)


Resveratrol

Resveratrol

  • Potential NF-κB Inhibitor

  • Natural compound found in red wine, red grapes

  • Increased life span of nematode and short-lived fish

  • If good enough for the nematode, why not for us?


Putting resveratrol to the test

Putting Resveratrol to the Test

Day 0 –Tumor Inoculation

Days 1-17 Document Cachexia/Treat with Resveratrol

Sacrifice and Harvest


Outcomes

Outcomes

  • Tumor size

  • Body weight

  • Tissue NFκB levels

  • Cardiac echo readings


Otology neurotology

Otology/Neurotology

  • Doug Fitzpatrick, Ph. D. – Preservation of residual hearing in cochlear implantation

  • Paul Manis, Ph. D. – Cellular mechanisms/neural networks of hearing

  • John Grose, Ph. D. – Age-Related decline in temporal processing

  • Craig Buchman, MD – Auditory Neuropathy, CI Outcomes

  • Oliver Adunka, MD – Electroacoustic Stimulation (EAS); Intraoperative electrophysiology

  • Joe Hall Ph. D./Emily Buss – Psychoacoustics

  • Joseph Roche, MD – SNHL and synaptic plasticity in Te1

Vestibulocochlear system of the Mongolian Gerbil; animal model used in electroacoustic studies


Facial plastic and reconstructive surgery

Facial Plastic and Reconstructive Surgery

  • William Shockley, MD

  • Interests: Microtia repair, nasal defects and rhinoplasty, congenital anomalies

  • Clinical Outcomes Research


Rhinology sinus surgery

Rhinology/Sinus Surgery

  • Julia Kimbel, Ph. D. – computational fluid dynamics, particle uptake deposition

  • Brent Senior, MD – MIPS Outcomes Research, Sleep Research

  • Charles Ebert, MD – QOL Outcomes for sinus surgery, Allergic Fungal Rhinosinusitis


Allergic fungal rhinosinusitis

Allergic Fungal Rhinosinusitis

  • Disease process characterized by fungal proliferation, inflammation and deformation of the normal bony anatomy

  • Presents unilaterally in over 40% of patients

  • Hypothesis: These patients represent a genetic chimera with differential expression on the contralateral sides of the nose

  • Microarray analysis will be used to characterize these differences


Laryngology

Laryngology

  • Robert Buckmire - Medical Robotic System for Laser Phonomicrosurgery

    • Joint venture with UNC/NC State Dept. of Biomedical Engineering

  • Image Guidance in

    Laryngeal Surgery


Laryngeal phonomicrosurgery

Laryngeal Phonomicrosurgery

  • Group of Complex surgical techniques that leverage the use of endoscopic tools

  • Surgical laser (CO2) under the control of a micromanipulator

  • Problem: poor ergonomics


Laryngeal phonomicrosurgery1

Laryngeal Phonomicrosurgery

  • Hypotheses:

    • Different user interfaces may be advantageous in providing increased fine motor manipulation of the laser.

    • A trained robot may make more precise, uniform cuts than those made by a human


Skull base surgery

Skull Base Surgery

  • Adam M. Zanation, MD – Molecular biology of sinonasal tumors, radioanatomic analysis of the pediatric skull base, outcomes research in endoscopic skull base surgery

PPF

PPF

GPC

GPC

Mucosa

Mucosa


Pediatric otolaryngology

Pediatric Otolaryngology

  • Amelia Drake, MD

  • Austin Rose, MD

  • Carlton Zdanski, MD, FACS

  • Rose Payapilli, MD (resident) – clinical outcomes in patients with cochlear malformation after CI


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