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FK506 & MMF

A). FK506 & MMF. FK506 & MMF. rAAV5- pbgd. ATG & Methylprednisolone. rAAV5- egfp. ATG & Methylprednisolone. Rituximab. Rituximab. M003. M002. weeks. M001. 0. 2. 4. 6. 12. 17. 23. 25. M 004. Biopsy. Sacrifice. NHP001 w/o IS. NHP002 with IS. rAAV5- pbgd. rAAV5- egfp.

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FK506 & MMF

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  1. A) FK506 & MMF FK506 & MMF rAAV5-pbgd ATG & Methylprednisolone rAAV5-egfp ATG & Methylprednisolone Rituximab Rituximab M003 M002 weeks M001 0 2 4 6 12 17 23 25 M004 Biopsy Sacrifice NHP001 w/o IS NHP002 with IS rAAV5- pbgd rAAV5- egfp NHP003 with IS rAAV5- pbgd rAAV5- pbgd rAAV5- egfp 1x108 1x107 1x106 Genome copies of rAAV-pbgd/ml of serum 1x105 1x104 1x103 Weeks 1x102 0 5 10 15 20 25 7.6×104 4.8×104 3.0×104 1.9×104 1.2×104 nAB titer (1/IC50) Log Scale. 10000 1000 100 10 B) C) -10 -5 5 10 15 20 25 14 In vitro mitogenic response of PBMC to rAAV5 capsids stimulation index (cpm) 10 6 4 3 2 1 Weeks -5 5 10 15 20 25 D) Weeks

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