Inaugurele rede Utrecht, 10 februari 2012

1. Van dier naar mens Zoönosen in een wereld in verandering Inaugurele rede Utrecht, 10 februari 2012 Roel A. Coutinho Hoogleraar Epidemiologie en bestrijding van Infectieziekten in het bijzonder in het veterinair/humane domein Faculteit Geneeskunde en Diergeneeskunde Universiteit van Utrecht Julius Center for Health Science and Primary Care, UMCU

2. Pictures: by courtesy of Eugene Gavrilin. WHO

3. Herpen (Gem.Oss)

4. Table 2. Number of goats in The Netherlands H.J. Roest et al., The Q fever epidemic in The Netherlands, Epidemiol.Infect. 2011,139,1-12

6. Goat and sheep farms and residential adresses of human Q fever cases 14 April – 10 August 2008 Attack rate analysis for source detection Schimmer et al, BMC inf dis 2010,10:69

8. . Fig.1 NJ tree (topology only) of poxviruses based on concatenated amino acid sequences from 29 conserved orthologous proteins (13, 475 aligned sites). The tree was constructed on the basis of the JTT amino acid distance, assuming that rate variation among sites follows a gamma distribution (shape parameter a = 0.86). Numbers on the branches represent percentages of 1000 bootstrap samples supporting each branch; only values ≥50% are shown. For accession numbers of genome sequences, see Supplementary S1 AL Hughes et al, The evolutionary biologiy of poxviruses. Infection, genetics and evolution 2010:10;50-59

9. Typical clinical presentation of human monkeypox in a 7-y-old female child, Sankuru District, Democratic Republic of Congo. Rimoin A W et al. PNAS 2010;107:16262-16267 ©2010 by National Academy of Sciences

10. Rimoin et al. PNAS 2010;107:37 (16265)

11. Extended Spectrum Beta-lactamasen (ESBLs) Enzymen die beta-lactam antibiotica afbreken Penicilline, ampicilline, amoxicilline Alle cefalosporinen Infecties door bacteriën die ESBLs produceren zijn moeilijker te behandelen 1e keuze therapie ceftriaxon bij ernstige infecties Genen zijn veelal overdraagbaar via plasmiden Eenvoudige verspreiding van bacterie naar bacterie

12. Antibiotic Usage in Animals in NL

13. Publicatie in CMI

14. Ungulates Carnivores Rodents Nonmammals Primates Other Bats Mammals Woolhouse et al. Host range and emerging and reemerging pathogens Emerg Inf Dis 2005;11:12

16. Wolfe et al. Naturally acquired simian retrovirus infections in Central African Hunters. Lancet:363;932-937

18. Diamond J. Evolution, consequences and future of plant and animal domestication. Nature;2002: 418 (700-707)

20. Furuse et al. Origin of measles virus: divergence from rinderpest virus between 11th and 12th century. Virology Journal 2010; 7: 52 ev.

23. Fig.1. Phylogeny of the bordetellae based on comparitive genome hybridization data. The scale bar represents 100 evolutionary events (reproduced with permission from Ref.[10]). The different clades discussed in the main text are marked in different colors (Bpe=Bordetella pertissus, Bbr=B.bronchiseptica, Bpp=B.parapertussis). Non-human strains are also labeled by the host species. Bjornstad et al; Evolution and emergence of bordetalla in humans; trends in microbiology; 2005;13 (355-359) fig 1

29. Keesing et al. Impacts of biodiversity on the emergence and transmission of infectious diseases Nature 2010;468:647-652

30. Dizney et al. Increased host species diversity and drecreased prevalence of Sin Nombre virus Emerg Inf Dis 2009;15:7

32. Keesing et al. Impacts of biodiversity on the emergence and transmission of infectious diseases Nature 2010;468:647-652