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Pathophysiology of Anaphylaxis

Pathophysiology of Anaphylaxis. Dr Hettiarachchi Consultant Anaesthetist SBSCH- Peradeniya. Type I – Allergic Response. Immediate Hypersensitivity By IgE. First exposure to allergen. Second exposure to antigen. Second exposure to antigen. Histamine Leukotrienes

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Pathophysiology of Anaphylaxis

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  1. Pathophysiology of Anaphylaxis Dr HettiarachchiConsultant AnaesthetistSBSCH- Peradeniya

  2. Type I – Allergic Response • Immediate Hypersensitivity • By IgE

  3. First exposure to allergen

  4. Second exposure to antigen

  5. Second exposure to antigen Histamine Leukotrienes Prostaglandins

  6. Diagnosis Not always obvious

  7. 3 criteria Sudden onset and Rapid progression Life-threatening ABC Skin and/or Mucosal changes

  8. Remember Skin or mucosal changes alone are not a sign

  9. Remember Gastrointestinal symptoms

  10. Airway problems

  11. Airway problems

  12. Breathing problems Shortness of breath • Increased respiratory rate

  13. Breathing problems

  14. Circulation Problems Pale, Clammy • Hypotension, Tachycardia

  15. Circulation Problems

  16. Disability

  17. Exposure

  18. DIFFERENTIAL DIAGNOSIS

  19. DIFFERENTIAL DIAGNOSIS Non-Life-threatening conditions

  20. DIFFERENTIAL DIAGNOSIS • Idiopathic (non-allergic) • urticariaor angioedema Non-Life-threatening conditions Breath-holding episode in a child

  21. ?

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