1 / 16

How do Calcium and Potassium conductance affect atrial fibrillation?

How do Calcium and Potassium conductance affect atrial fibrillation?. Fluctus (Group 3) Maisam T. Begum Joshua Finer Peter Valdez. Over 2.2 million people in the US have atrial fibrillation (8 - 9% of people over 80). Blood clots can form, leading to a stroke.

omar
Download Presentation

How do Calcium and Potassium conductance affect atrial fibrillation?

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. How do Calcium and Potassium conductance affect atrial fibrillation? Fluctus(Group 3) Maisam T. Begum Joshua Finer Peter Valdez

  2. Over 2.2 million people in the US have atrial fibrillation (8 - 9% of people over 80). Blood clots can form, leading to a stroke. Some symptoms include irregular heart beats, chest pain, and shortness of breath. Still not well understood. Atrial Fibrillation

  3. TNNP Model • Based on experimental data. • Attempts to more accurately represent the action potential than other models by including more than a minimal number of parameters. • Computationally tractable (especially with progress in GPUs).

  4. Calcium conductance: GCaL Potassium conductance: GKs Conductance

  5. Generates inward Calcium current (ICaL). Depolarizes cell. L Type Calcium Channels Potassium Channels • Generates outward Potassium current. • Hyperpolarizes cell. • Includes slow outward Potassium current (IKs).

  6. http://www.nature.com/nature/journal/v451/n7181/fig_tab/nature06799_F2.htmlhttp://www.nature.com/nature/journal/v451/n7181/fig_tab/nature06799_F2.html

  7. http://www.cvpharmacology.com/antiarrhy/cardiac_action_potentials.htmhttp://www.cvpharmacology.com/antiarrhy/cardiac_action_potentials.htm

  8. Increasing GCaL would increase ICaL and make the spiral wave thicker. Increasing GKs would increase IKs and make the spiral wave thinner. Hypothesis

  9. Parameter Range: 25% - 185% Parameter Increment: 20% Methods GKs GCal

  10. Results

  11. Loop & Hook GCaL= 65% GKs= 145%

  12. Drift GCaL= 125% GKs= 85%

  13. Spin GCaL= 65% GKs= 65%

  14. Our hypothesis was wrong since many of the spiral waves looked very similar. It is difficult to draw a conclusion since many of the spirals looked very similar. We think there might be a well-defined pattern of the spiral wave tip path. Discussion/Conclusion

  15. Repeat simulations (with slight variations). Change more than 2 parameters at a time. Include the graphs of how membrane potential changes over time. Look at single individual periods. Future Work

  16. A special thanks to Dr. Griffeth, Dr. Fenton, Aron, Chuck, Rachel, Dan and CMACS. Acknowledgments

More Related