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http://www.nrlc.org/news_and_views/April10/lorenzosoil.jpg. Biography Full Name:  Lorenzo Odone Born:  29th May 1978 Passed Away:  30th May 2008 Age: 30 years of age Location:  Virginia, Washington Country:  The United States Father:  Augusto Mother:  Michaela.

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slide2

Biography

Full Name: Lorenzo Odone

Born: 29th May 1978

Passed Away: 30th May 2008

Age: 30 years of age

Location: Virginia, Washington

Country: The United States

Father: Augusto

Mother: Michaela

http://i.telegraph.co.uk/telegraph/multimedia/archive/01159/portal-graphics-20_1159181a.jpg

slide3

http://www.jerrypettit.com/blog/wp-content/uploads/2008/05/lorenzo.jpghttp://www.jerrypettit.com/blog/wp-content/uploads/2008/05/lorenzo.jpg

http://images.mirror.co.uk/upl/m3/jun2008/1/4/432AD37F-A9F8-CC33-B7069F64B2660271.jpg

Lorenzo was an intelligent and happy young boy….until

slide4

One day…

http://boomeryearbook.com/blog/wp-content/uploads/2009/06/byb-temper-tantrum-cartoon.jpg

http://www.cartoonstock.com/lowres/jfa0454l.jpg

Lorenzo’s behaviour drastically changed for the worse.

slide5

So, his parents took him to the doctor…

They then ran various tests to find out what was wrong…

http://irm.am.szczecin.pl/ludzie_priv/maciek/wordpress/wp-content/uploads/2008/07/cox.jpg

http://www.saifeehospital.com/images/Facilities/46_CT_Scan.jpg

slide6

They found that…

http://bluefingers.files.wordpress.com/2008/03/ct-scan.jpg

http://www.x-ald.nl/diagnosis.htm

http://www.x-ald.nl/diagnosis.htm

Lorenzo had the neurological disease Adrenoleukodystrophy (ALD).

slide7
ALD

http://www.nlm.nih.gov/medlineplus/ency/images/ency/fullsize/17277.jpg

http://www.x-ald.nl/carrier400.jpg

slide8

There is no transporter protein to transport an enzyme to breakdown long chain saturated fats therefore:

Certain cells are made by the saturated fats, however without the enzyme to destroy extra fat, the excess it builds up

C24

http://www.x-ald.nl/biochemistry.htm

C26

http://www.x-ald.nl/biochemistry.htm

Which destroys

http://www.wiredtowinthemovie.com/images/hotspots/level06myelinSheath.jpg

slide9
Losing myelin will eventually inhibit the brain\'s ability to control the body and the person eventually dies…

http://www.bangitout.com/uploads/22blind-man.jpg

http://4.bp.blogspot.com/_tWcMxuwF6hg/SbXKypfW4aI/AAAAAAAAAYY/h3NSy5_NVHo/s400/mute.gif

http://www.google.ca/imgres?imgurl=http://www.dundee.ac.uk/disabilityservices/disability/leaflets/Image12.gif&imgrefurl=http://theheroesfestival.co.uk/information/8/Travel.htm&usg=__uSsg8h3c08yRVA bcckFvki9emHM=&h=621&w=626&sz=5&hl=en&start=7&um=1&itbs=1&tbnid=PZBSzsWTpckOBM:&tbnh=135&tbnw=136&prev=/images%3Fq%3DDisabled%26um%3D1%26hl%3Den%26tbs%3Disch:1

http://iannoon.files.wordpress.com/2010/03/deaf.jpg

Lorenzo was given 2 years to live.

slide10

Augusto and Michaela are saddened by the news of Lorenzo’s condition…

http://www.psychologytoday.com/files/u45/sad_man.jpg

slide11
In order to help Lorenzo, both Augusto and Michaela enroll Lorenzo in a clinical trial dictated by Dr. Nikolai…

C24

http://www.x-ald.nl/biochemistry.htm

C26

Decrease

http://www.x-ald.nl/biochemistry.htm

https://wiki.uwc.edu/images/a/ab/Saturated-fats-picture.jpg

In

michaela finds out lorenzo had received the disease from her
Michaela finds out Lorenzo had received the disease from her…

http://www.ntsad.org/images/Transmission_of_X-Linked_Traits.gif

the clinical trial is initially is not working
The Clinical trial is initially is not working…

C24

http://www.x-ald.nl/biochemistry.htm

C26

Increase of

http://www.x-ald.nl/biochemistry.htm

https://wiki.uwc.edu/images/a/ab/Saturated-fats-picture.jpg

In

lorenzo is also enrolled into another clinical trial involving cyclophosphides
Lorenzo is also enrolled into another clinical trial involving Cyclophosphides

http://www.picturemosaics.com/tools/crop/display.php?n=4c0c171089317.jpg&c=your%20custom%20value

http://upload.wikimedia.org/wikipedia/commons/thumb/c/cd/Cyclophosphamide_structure.svg/481px-Cyclophosphamide_structure.svg.png

doctors analyze lorenzo after taking the cyclophophide
Doctors analyze Lorenzo after taking the Cyclophophide

The Desase is still progressing however. They observed hemianopia, with transient horizontal nystagmus. The pupillary light reflexes were still intact, as yet, there was no optic atrophy.

http://www.youtube.com/watch?v=Ey9NC18Jz2s&NR=1

http://www.youtube.com/watch?v=Ey9NC18Jz2s&NR=1

the odones were then contacted by ellard muscatine concerning the ald foundation
The Odones were then contacted by Ellard Muscatine concerning the ALD foundation…

In response, they head to the ALD Family Conference in July.

http://www.aldfoundation.org/images/index_left.jpg

http://www.youtube.com/watch?v=Ey9NC18Jz2s&NR=1

at the conference the topic of the saturated food clinical trial is brought up by michaela
At the conference, the topic of the saturated food clinical trial is brought up by Michaela…

http://thejobsearchguru.com/notesfrom/wp-content/uploads/2009/02/rejected.jpg

Others were experiencing the same results as the Odone’s were.

http://www.youtube.com/watch?v=Ey9NC18Jz2s&feature=related

in order to understand lorenzo s condition better
In order to understand Lorenzo’s condition better…

http://etc.usf.edu/clipart/19900/19900/studying_19900_lg.gif

Through studying, Augusto described Lorenzo\'s condition through the use of a sink:

Tap on the right represents very long chain saturated fats. Now, also produced by the body or manufactured by the body, are these very same fats (biosynthesis). It shouldn\'t be problem since an enzyme breaks down the excess, however in Lorenzo’s case the enzyme is not present. In the case of the sink, the drain is blocked.

http://www.youtube.com/watch?v=X_IS2NL6R9E&NR=1

slide19

While at the library, Michaela had stumbled upon an article about fatty acid manipulation

http://shelfelf.files.wordpress.com/2008/01/trinity-college-library-dub.jpg

In a polish study, when rats were deprived of a specific fat in their diet, body cells compensated by overproducing it.

slide20

So they hypothesized that they can stop the body from producing one kind of fat:

http://www.x-ald.nl/biochemistry.htm

http://www.x-ald.nl/biochemistry.htm

By loading it with another:

http://upload.wikimedia.org/wikipedia/commons/archive/f/f3/20051022203016!Question_mark_alternate.png

slide21
Reporting to Dr. Nikolai, both Augustus and Michaela wished to put together a symposium in order to exchange information.

http://3pillarsofwits.files.wordpress.com/2010/02/600px-jigsaw_svg.png

http://www.mahoganymasterpieces.com/Images/big_image/174_conference%20table5.jpg

http://www.unc.edu/world/College_Updates_2009/world-globe.jpg

however it was difficult to actually try and achieve this tremendous feat
However, it was difficult to actually try and achieve this tremendous feat.

http://ase.org/images/lib/tips/nomoney.jpg

http://blogs.discovermagazine.com/cosmicvariance/files/2008/11/time-flies-clock-10-11-2006.gif

at the symposium
At the symposium…

http://www.youtube.com/watch?v=X_IS2NL6R9E&NR=1

They discussed how the clinical trial was not working.

The case study was also brought up which shed a new a light on the disease.

And with the combined knowledge of researchers from all over the world…

slide24

http://upload.wikimedia.org/wikipedia/commons/archive/f/f3/20051022203016!Question_mark_alternate.pnghttp://upload.wikimedia.org/wikipedia/commons/archive/f/f3/20051022203016!Question_mark_alternate.png

http://1.bp.blogspot.com/_DvUbyOlnKyQ/S7IytMe8E0I/AAAAAAAAAsM/MelrpumxOTg/s1600/Caprylic+Capric+Oleic+Acids.BMP

If it is in its pure form, it becomes hazardous however if it is in its triglyceride form then it is edible.

http://www.shingleberrysigns.com/design_icon/warning%2015%20toxic.gif

in order to have oleic acid
In order to have oleic acid…

Extraction

Of C24

  • http://www.x-ald.nl/biochemistry.htm

And C26

  • http://www.x-ald.nl/biochemistry.htm

http://www.liquid-extraction.com/images/typical-extraction.jpg

From olive oil

  • http://1.bp.blogspot.com/_DvUbyOlnKyQ/S7IytMe8E0I/AAAAAAAAAsM/MelrpumxOTg/s1600/Caprylic+Capric+Oleic+Acids.BMP

http://weblogs.cltv.com/news/local/chicago/Money%20stacks.jpg

http://static.open.salon.com/files/how-olive-oil-works-31222748225.jpg

the solution is there but
The solution is there but…

Companies were being stubborn

http://www.sabrina.sg/files/20080901-Rejected.gif

http://www.google.ca/images?um=1&hl=en&tbs=isch%3A1&sa=1&q=Telephone&aq=f&aqi=g10&aql=&oq=&gs_rfai=

Also, Lorenzo’s condition worsened to a point were he needed spit suctioned out of his mouth.

http://www.youtube.com/watch?v=PU_3JrjZVak&feature=related

after many attempts
After many attempts…

Protochem Laboratories

http://1.bp.blogspot.com/_DvUbyOlnKyQ/S7IytMe8E0I/AAAAAAAAAsM/MelrpumxOTg/s1600/Caprylic+Capric+Oleic+Acids.BMP

http://www.indiamart.com/protochem/pcat-gifs/homepage/logo.jpg

And the Odone’s were sent an extra bottle.

http://www.nahanniriverherbs.com/uploads/food+plants/oil_bottle.jpg

dr nikolai however warned the odone s about putting untested substances into lorenzo
Dr. Nikolai however warned the Odone’s about putting untested substances into Lorenzo..

http://webpub.allegheny.edu/dept/psych/Pictures/Ethical.jpg

Is it really ethical of the Odones to put untested substances into Lorenzo?

http://i243.photobucket.com/albums/ff71/death_dealer_1/Angel_of_Death.jpg

http://www.bbc.co.uk/blogs/ni/GOD2.jpg

slide29

ttp://media.photobucket.com/image/drawing%20blood%20for%20a%20baseline/mikeyismyfriend/drawing_blood.jpgttp://media.photobucket.com/image/drawing%20blood%20for%20a%20baseline/mikeyismyfriend/drawing_blood.jpg

And then...

Blood was drawn for a baseline

Lorenzo was given the oleic oil through food

http://blogs.kqed.org/bayareabites/files/2009/09/cooked-barracuda.jpg

one month later
One month later…

A small percent drop of C24 and C26 was found in Lorenzo’s blood work.

http://www.istockphoto.com/file_thumbview_approve/8141806/2/istockphoto_8141806-bar-graph-decrease.jpg

http://www.google.ca/images?um=1&hl=en&tbs=isch%3A1&sa=1&q=Telephone&aq=f&aqi=g10&aql=&oq=&gs_rfai=

However…

Not soon after the call did Lorenzo suffer from paroxysm (saliva gets caught in the trachea.)

http://www.google.ca/imgres?imgurl=http://www.mdconsult.com/das/patient/body/0/0/10041/19076_en.jpg&imgrefurl=http://www.mdconsult.com/das/patient/body/0/0/10041/30160.html&usg=__OdiwFRPM7MpJEjCSWNvHOyU1Sxw=&h=320&w=400&sz=13&hl=en&start=1&sig2=NAqQDOi2vZNhSKaAqfWT7A&um=1&itbs=1&tbnid=6Spb3Kd455PzHM:&tbnh=99&tbnw=124&prev=/images%3Fq%3Dseizure%26um%3D1%26hl%3Den%26tbs%3Disch:1&ei=92sMTMaMJ4aKlwexiJyQDg

slide31

The next update the Odone’s were given were...

50% drop in both C24 and C26 fatty acids.

http://www.youtube.com/watch?v=PU_3JrjZVak&feature=related

slide32
In order to spread the good news about the Oleic acid the Odone’s had invited the Muscatine to dinner however…

They were being quite stubborn about accepting the Odone’s research.

http://themoderatevoice.com/wordpress-engine/files/2009_November/stubborn.jpg

http://static.open.salon.com/files/argument1227837759.jpg

in february
In February…

The decrease in C24 and C26 fatty acids were barely noticeable..

http://www.youtube.com/watch?v=PU_3JrjZVak&feature=related

And, as time continued, Lorenzo’s condition continually becomes worse.

http://www.youtube.com/watch?v=PU_3JrjZVak&feature=related

slide34
Augusto decided that he would not give up and instead, research why the oil only decreased the amount of fatty acids by 50%.

http://mechanicrobotic.files.wordpress.com/2007/09/cathedral-library-kalocsa.jpg

http://www.routeoneforlife.com/wp-content/uploads/2009/05/studyhard.jpg

in order to explain the build up of very long fatty acid chains augusto used a paper clip analogy
In order to explain the build up of very long fatty acid chains Augusto used a paper clip analogy

http://www.youtube.com/watch?v=dLBkzlJrfLA&feature=related

http://www.youtube.com/watch?v=dLBkzlJrfLA&feature=related

Each paper clip equaled 2 carbon atoms.  These would connect to other carbon atoms in chains, such as C2-C4-C6.  These chains where trying to make monosaturated fats.  One chain was considered the "good guys" while the other chain was considered to be the "bad guys".  The father was the "good guy enzyme" and took a carbon and put it on his chain. Deidra however was the " bad guy enzyme" and put a carbon on her chain. This was done at the same rate. However, what confused him was why when the faster the “good guys” went, the slower the “bad guys” went, if they were both separate enzymes?

however luckily for augustus he fell asleep and had an epiphany from a dream
However, luckily for Augustus, he fell asleep and had an epiphany from a dream…

http://www.youtube.com/watch?v=dLBkzlJrfLA&feature=related

The answer that had come to him was that they were both the same enzyme.

http://www.youtube.com/watch?v=dLBkzlJrfLA&feature=related

with this knowledge
With this knowledge…

So if they keep the enzyme busy making monounsaturated fats, it stops the enzyme from elongating the chain.

This Process is known as Competitive Inhibition.

http://en.wikipedia.org/wiki/File:Comp_inhib.svg

It explains why oleic oil was only partly successful, since it was too low down the chain. Therefore, by adding erucic acid, it creates a second barrier and blocks the “bad guys” further up the chain.

Erucic Acid

http://upload.wikimedia.org/wikipedia/commons/5/54/Erucic_acid.png

however
However…

Just like the oleic acid, Dr. Nikolai was hesitant about using Erucic acid upon Lorenzo since it causes heart problems on rats.

http://www.oralchelation.com/heart/images/worried.gif

Erucic acid however has to have its C24 and C26 fats removed and it is difficult to have synthesized.

http://home.comcast.net/~blake.flynn/paintings/timeconsuming.html

through some luck however
Through some luck however…

A British chemist known as Don Suddaby working for Croda International decided to take on the task that the Odone’s had set.

http://upload.wikimedia.org/wikipedia/en/3/3f/Crodalogo.PNG

http://www.youtube.com/watch?v=66OKZGeLncs&feature=related

slide40
Michaela however was having continuous problem with various nurses so she decided to call an old friend of Lorenzo- Omouri.

Problems

http://www.youtube.com/watch?v=66OKZGeLncs&feature=related

http://media.photobucket.com/image/sexy%20cartoon%20Nurse/Freefreq/Nurse/images/Nurse4.jpg

one day
One day…

Mr. Suddaby had managed to synthesize the erucic acid and had it delivered to the Odone’s.

http://www.youtube.com/watch?v=66OKZGeLncs&feature=related

Deidra was used a test “rat” for the erucic acid. There were no harmful after effects which therefore meant it could be given to Lorenzo.

http://www.boston.com/lifestyle/food/dishing/rat.jpg

in september
In September…

Lorenzo’s blood sample had come back with C24 and c25 reading normal.

http://www.nileclub.org/uploads/Eid_Celebration.jpg

http://llenrock.com/blog/wp-content/uploads/2009/12/party.gif

after lorenzo s success
After Lorenzo’s success

Lorenzo continued improving, even to point where he was able to swallow his own saliva.

http://www.youtube.com/watch?v=uWNvZ4dEjGU&feature=related

A sample was given to Wendy, and the same results were received with her child. This sparked a potential of a trial to be created.

http://www.youtube.com/watch?v=uWNvZ4dEjGU&feature=related

lorenzo continually improved as time wore on
Lorenzo continually improved as time wore on…

With at first being able to communicate with his eyes…

http://www.youtube.com/watch?v=uWNvZ4dEjGU&feature=related

and then even being able to move a finger.

http://www.youtube.com/watch?v=uWNvZ4dEjGU&feature=related

slide45

Meanwhile Lorenzo made it past the age of 20. He was able to move his head from side to side. He had also recovered his eyesight and had begun to vocalize simple sounds. He was learning to communicate by means of a computer. However, on May 30, 2008 (aged 30), he died from aspiration pneumonia.

http://www.myelin.org/attachments/wysiwyg/1/LO%202002-hi.jpg

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