Circadian rhythms and aging
This presentation is the property of its rightful owner.
Sponsored Links
1 / 17

Circadian rhythms and aging PowerPoint PPT Presentation


  • 114 Views
  • Uploaded on
  • Presentation posted in: General

Circadian rhythms and aging . Julia Tong RE|NOUS March 03, 2014 General Meeting III . Outline. What is circadian rhythms (CR)? How does CR pertain to aging? How does CR affect AD? . Circadian Rhythms . Body go through cycles each day to maintain homeostasis.

Download Presentation

Circadian rhythms and aging

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Circadian rhythms and aging

Circadian rhythms and aging

Julia Tong

RE|NOUS

March 03, 2014

General Meeting III


Outline

Outline

  • What is circadian rhythms (CR)?

  • How does CR pertain to aging?

  • How does CR affect AD?


Circadian rhythms

Circadian Rhythms

  • Body go through cycles each day to maintain homeostasis.

  • Every cell in your body has a rhythm (internal clock) and the output oscillates according to the environment.

  • Examples:

    • Blood pressure

    • Melatonin levels

    • Liver enzymes

    • Body temperature


Circadian rhythms ii

Circadian Rhythms II

  • Think of bodily functions and secretions are clocks

  • SCN is the central clock

    • It is the site of the biological clock

    • Without it, the body is arrhythmic

    • Animal dies


Scn is critical to circadian rhythms

SCN is critical to Circadian Rhythms

Lehman et al. 1987


Central clock genes

Central Clock Genes


Circadian rhythms and aging1

Circadian Rhythms and Aging

  • Aging changes the human circadian behavior

  • Older humans/animals circadian activity cycle shortens with age.

    • Think about your own circadian (sleep/wake) cycle!

  • Numerous studies have shown CR interconnected with longevity and age related changes in rhythms.

  • No clear mechanistic or molecular factors identified yet.


  • Circadian rhythms and aging

    Looking at SIRT1 role in central circadian control of physiology and behavior


    Results

    Results


    Jetlag

    Jetlag


    Circadian rhythms and aging

    SIRT1 Function


    Paper s conclusion

    Paper’s Conclusion

    • SIRT1 regulate central circadian control to determine period, acitivty level, and adjust to reentrainment.

    • SIRT1 directly activates Bmal1 in SCN

      • Increasing expression of other clock genes

    • Aged mice have low SIRT1 and BMAL1

      • Inability to adjust to abrupt light adaptation

    • Overexpressing brain SIRT1 are partially protected

      • Reversitol

      • Low fat diet


    Cr and alzheimer s disease

    CR and Alzheimer’s Disease

    • AD pts. have disrupted CR

    • Sundowning: agitated during evening

      • Never get a complete night sleep, issues with sleep/wake cycle.

      • Sleep disturbances have devastating effects that leaves pts. Institutionalize.

    • Studies show that AD pts have disturbances in CR and sundowning is related to phase delay of body temperature


    Slow aging with a good clock

    Slow aging with a good clock

    • Treat age related diseases by enhancing Circadian Function.

      • SIRT1 to brain

      • Other drugs along pathway

    • Treatment for AD patients, ease sundowning

      • Adjust patients to the Light/dark cycle

      • Understand patient’s CR

        • Sync them to environment

          • Bright light during morning

          • Melatonin at night


  • Login