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Circadian rhythms and aging . Julia Tong RE|NOUS March 03, 2014 General Meeting III . Outline. What is circadian rhythms (CR)? How does CR pertain to aging? How does CR affect AD? . Circadian Rhythms . Body go through cycles each day to maintain homeostasis.

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Circadian rhythms and aging

Circadian rhythms and aging

Julia Tong

RE|NOUS

March 03, 2014

General Meeting III


Outline
Outline

  • What is circadian rhythms (CR)?

  • How does CR pertain to aging?

  • How does CR affect AD?


Circadian rhythms
Circadian Rhythms

  • Body go through cycles each day to maintain homeostasis.

  • Every cell in your body has a rhythm (internal clock) and the output oscillates according to the environment.

  • Examples:

    • Blood pressure

    • Melatonin levels

    • Liver enzymes

    • Body temperature


Circadian rhythms ii
Circadian Rhythms II

  • Think of bodily functions and secretions are clocks

  • SCN is the central clock

    • It is the site of the biological clock

    • Without it, the body is arrhythmic

    • Animal dies




Circadian rhythms and aging1
Circadian Rhythms and Aging

  • Aging changes the human circadian behavior

  • Older humans/animals circadian activity cycle shortens with age.

    • Think about your own circadian (sleep/wake) cycle!

  • Numerous studies have shown CR interconnected with longevity and age related changes in rhythms.

  • No clear mechanistic or molecular factors identified yet.



  • Results
    Results physiology and behavior


    Jetlag
    Jetlag physiology and behavior


    SIRT1 Function physiology and behavior


    Paper s conclusion
    Paper’s Conclusion physiology and behavior

    • SIRT1 regulate central circadian control to determine period, acitivty level, and adjust to reentrainment.

    • SIRT1 directly activates Bmal1 in SCN

      • Increasing expression of other clock genes

    • Aged mice have low SIRT1 and BMAL1

      • Inability to adjust to abrupt light adaptation

    • Overexpressing brain SIRT1 are partially protected

      • Reversitol

      • Low fat diet


    Cr and alzheimer s disease
    CR and Alzheimer’s Disease physiology and behavior

    • AD pts. have disrupted CR

    • Sundowning: agitated during evening

      • Never get a complete night sleep, issues with sleep/wake cycle.

      • Sleep disturbances have devastating effects that leaves pts. Institutionalize.

    • Studies show that AD pts have disturbances in CR and sundowning is related to phase delay of body temperature


    Slow aging with a good clock
    Slow aging with a good clock physiology and behavior

    • Treat age related diseases by enhancing Circadian Function.

      • SIRT1 to brain

      • Other drugs along pathway

    • Treatment for AD patients, ease sundowning

      • Adjust patients to the Light/dark cycle

      • Understand patient’s CR

        • Sync them to environment

          • Bright light during morning

          • Melatonin at night


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