The Mutability and Repair of DNA
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The Mutability and Repair of DNA. REPLICATION ERRRORS AND THEIR REPAIR. The nature of mutations. Transitions. Transversions. Some replication errors escape proofreading. Mismatch repair removes errors that escape proofreading. Structure of MutS and DNA

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The Mutability and Repair of DNA

REPLICATION ERRRORS AND THEIR REPAIR

The nature of mutations

Transitions

Transversions




Structure of MutS and DNA

(MutS recognizing mismatches from the distortion they cause)


Dam methylation in E. coli replication fork



DNA DAMAGE

DNA undergoes damage spontaneously from hydrolysis and deamination



Thymine dimer caused by UV light



Ames test for in DNAcarcinogens


Bruce N. Ames in DNA

Professor of the Graduate School Division of Biochemistry and Molecular Biology, UC Berkeley






Structure of DNA- base-flipping mechanismglycosylase complex


How is an altered base detected within the context of the double-helix?

The recognition of an unusual nucleotide in DNA by base-flipping of glycosylase


Oxo double-helix?-G:A repair by a fail-safe glycosylase



Transcription-coupled DNA repair either side of the lesion


Recombination repair DNA breaks by retrieving sequence information from undamaged DNA

Double-Strand Breaks are Efficiently Repaired



Translesion ends DNA synthesis enables replication to proceed across DNA damage


Structures of a endstranslesion polymerase and a typical polymerase



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