The Mutability and Repair of DNA
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The Mutability and Repair of DNA. REPLICATION ERRRORS AND THEIR REPAIR. The nature of mutations. Transitions. Transversions. Some replication errors escape proofreading. Mismatch repair removes errors that escape proofreading. Structure of MutS and DNA

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The Mutability and Repair of DNA

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The mutability and repair of dna

The Mutability and Repair of DNA

REPLICATION ERRRORS AND THEIR REPAIR

The nature of mutations

Transitions

Transversions


The mutability and repair of dna

Some replication errors escape proofreading


The mutability and repair of dna

Mismatch repair removes errors that escape proofreading


The mutability and repair of dna

Structure of MutS and DNA

(MutS recognizing mismatches from the distortion they cause)


The mutability and repair of dna

Dam methylation in E. coli replication fork


The mutability and repair of dna

Directionality in mismatch repair


The mutability and repair of dna

DNA DAMAGE

DNA undergoes damage spontaneously from hydrolysis and deamination


The mutability and repair of dna

DNA is damaged by alkylation, oxidation, and radiation


The mutability and repair of dna

Thymine dimer caused by UV light


The mutability and repair of dna

Base analogs and intercalating agents that cause mutations in DNA


The mutability and repair of dna

Ames test for carcinogens


The mutability and repair of dna

Bruce N. Ames

Professor of the Graduate School Division of Biochemistry and Molecular Biology, UC Berkeley


The mutability and repair of dna

REPAIR OF DNA DAMAGE


The mutability and repair of dna

Direct reversal of DNA damage


The mutability and repair of dna

Direct removal of the methyl group from O6 -methylguanine


The mutability and repair of dna

Base excision repair enzymes remove damaged bases by a base-flipping mechanism


The mutability and repair of dna

Structure of DNA-glycosylase complex


The mutability and repair of dna

How is an altered base detected within the context of the double-helix?

The recognition of an unusual nucleotide in DNA by base-flipping of glycosylase


The mutability and repair of dna

Oxo-G:A repair by a fail-safe glycosylase


The mutability and repair of dna

Nucleotide excision repair enzymes cleave damaged DNA on either side of the lesion


The mutability and repair of dna

Transcription-coupled DNA repair


The mutability and repair of dna

Recombination repair DNA breaks by retrieving sequence information from undamaged DNA

Double-Strand Breaks are Efficiently Repaired


The mutability and repair of dna

DSBs in DNA are also repaired by direct joining of broken ends


The mutability and repair of dna

Translesion DNA synthesis enables replication to proceed across DNA damage


The mutability and repair of dna

Structures of a translesion polymerase and a typical polymerase


The mutability and repair of dna

Mutations are linked to cancer


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