Growth and Repair. dr. FAIRUZ QUZWAIN,SpPA,M.Kes Kepala bagian Patologi Anatomi FKIK-UNJA. Repair following inflammation: two simultaneous processes. Regeneration : replacement of injured/necrotic cells by cells of same type, often leaving no evidence of previous injury
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Growth and Repair
dr. FAIRUZ QUZWAIN,SpPA,M.Kes
Kepala bagian Patologi Anatomi
PHASES of Cell Cycle:
Which cyclin ?
Cyclin-dependent kinase inhibitors
Receptors without intrinsic tyrosine kinase
Receptors with intrinsic tyrosine kinase
Seven transmembrane (G protein-coupled)
Growth factors: coming soon!
Clinical application: if mutant ras protein is permanently fixed in active GTP form, what pathologic process may result?
sequences of DNA
Mitogenic for endothelial cells
Liver from living donor before transplantation, outlining right lobe to be used for grafting into recipient
Liver of donor one week post-partial hepatectomy, showing marked growth of left lobe (compensatory hyperplasia) without regrowth of right lobe. Why didn’t right lobe regrow also?
Skin (80%), bone (90%), tendons
Genetic deficiency of type IV in:
Nutrient required for hydroxylation of alpha chains:
Deficiency of this nutrient causes poor wound healing in disease called:
Inherited disorders of collagen synthesis, leading to defective fibers:
Skin, lung, uterus, ligaments, large blood vessels
Function: attach cells to ECM matrices; 2 glycoprotein chains held together by disulfide bonds; produced by fibroblasts, endothelial cells, & monocytes. Name?
Most abundant glycoprotein in basement membranes; it spans basal lamina and binds to both cell surfaces and ECM components:
Transmembrane glycoproteins with alpha and beta chains that bind to fibronectin, laminin, & collagen. This family of surface receptors mediate attachment of cell membranes to ECM:
These also mediate adhesion of which cell type to endothelium?
Major EC structural protein:
Fig. 3-16, Pathologic Basis of Disease, 7th ed, Elsevier 2005
ACUTE AND CHRONIC INFLAMMATION
Damage to parenchymal cells and interstitial framework
Regeneration of parenchymal cells whenever possible
Replacement of non-regenerated damaged tissue by what?
24 hrs: proliferation of fibroblasts & endothelial cells
Within 3-5 days:
Permanent result (weeks later)
Little mature collagen
Proliferation of young fibroblasts
blue-staining collagen (trichrome stain)
Healing by first intention
Healing by second intention
Wound tensile strength: 10% of normal at 7 days; 70-80% of normal at 3 months
face > trunk > extremities