Current or former* CITR centers: 28 Total recipients: 368 Total infusions: 694

1. Total transplant programs in North America polled for islet allograft transplantation 1999-2008: 46 Programs that have performed islet allograft transplantation: 32 Total recipients: 408 Total infusions: 783 Programs that have not performed any islet allograft transplants: 14 • Not Participating in CITR: 4Total recipients: 36Total infusions: 74 Current CITR centers: 3 No Data • Not Participating in CITR: 11 • No Data • Current or former* CITR centers: 28Total recipients: 368Total infusions: 694 • Reporting detailed information: 27** • Total recipients: 329Total infusions: 637 • CITR data included in 2009 Report Exhibit ANorth American Islet Allograft Transplant Centers, Recipients and InfusionsTotal Performed and Total Reported to CITR 1999-2008 Fifteen North American centers performed at least one islet allograft infusion procedure in 2008. Fourteen of these centers reported data to CITR. * Former CITR centers (N=3) are those that reported data to CITR then subsequently stopped performing islet cell transplants and discontinued CITR participation. ** One center with three allograft participants who did not provide CITR consent. ported the information to CITR.

2. Exhibit B – 1Number of Islet Transplantation Centers Performing Islet Allografts per Yearand Number with Data Entered in CITR Database All North American Islet Transplant Centers 1999-2008

3. Exhibit B – 2Total Number of Islet Allograft Recipients and Recipients with Detailed Data Reported to CITR by Year of First Islet Allograft Infusion CITRParticipating European and Australian JDRF Centers 1999-2008

4. Exhibit C – 1Insulin Independence, Insulin Dependence, Absence of Fasting C-peptide, or Re-InfusionPost First InfusionIslet Alone Recipients

5. Exhibit C – 2Insulin Independence, Insulin Dependenceor Absence of Fasting C-peptidePost Last InfusionIslet Alone Recipients

6. Exhibit DAchievement of Insulin Independence After Islet TransplantationNot Censored at Re-Infusion or Graft LossPost First InfusionIslet Alone vs. Islet After Kidney

7. Exhibit E – 1Persistence of Insulin IndependenceAllograft Recipients Achieving Insulin IndependencePost Last InfusionIslet Alone vs. Islet After Kidney

8. Exhibit E – 2Persistence of Insulin IndependenceAllograft Recipients Achieving Insulin IndependencePost Last Infusionby Era of First Infusion

9. Exhibit FPersistence of Islet Graft FunctionAll Allograft RecipientsPost Last InfusionIslet Alone vs. Islet After Kidney

10. Exhibit G – 1Composite Outcome (Hypoglycemia and HbA1c) Post Last InfusionIslet Alone Recipients

11. Exhibit G – 2 Hypoglycemia Status Pre First Infusion and Post Last Infusion All Allograft Recipients