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Non-Motor Contributions To Motion Deficits In Schizophrenia. Nestor Matthews 1,2 Bruce Luber 3,4 Ning Qian 2 Sarah H. Lisanby 3,4. Denison University, Dept. of Psychology 1 , Granville, OH, USA.

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  1. Non-Motor Contributions To Motion Deficits In Schizophrenia Nestor Matthews1,2 Bruce Luber 3,4 Ning Qian2 Sarah H. Lisanby 3,4 Denison University, Dept. of Psychology1, Granville, OH, USA Columbia University, Ctr. for Neurobiology & Behavior2, Dept. of Psychiatry3, Dept. of Biological Psychiatry4, New York, NY, USA Purpose Experimental Conditions Discussion It is well known that eye movements are impaired in patients with schizophrenia. Here we study motion sensitivity in patients before eye movements occur. We previously reported evidence that separate neural events mediate speed and direction discrimination (Matthews et al 1999, 2001). Same Stimulus, Different Task .... Same Task, Different Stimulus Motion Stimulus Speed Task Motion Stimulus Direction Task Motion Stimulus Brightness Task Scrambled Stimulus Brightness Task Stationary Stimulus Brightness Task Stimuli & Task Controls Accordingly, a neuro-pathological process, such as schizophrenia, could in principle differentially affect speed and direction discrimination. A trial comprised two random-dot patterns, each presented for a duration (200 ms) too brief for reliable eye movements. Patients The task required judging the speed, direction, or brightness of the second stimulus relative to the first. However, these data indicate that both speed and direction discrimination are impaired in patients. This is true even before eye-movements have begun. Results Across these three tasks the stimuli (schematized below) were identical. Bottom Line Our findings suggest that eye- movement deficits in patients with schizophrenia are at least partially due to impaired perceptual input. References Matthews & Qian (1999). Axis-of-motion affects speed discrimination, not direction discrimination. Vision Research, 39(13), 2205-2211. Matthews, Luber, Qian & Lisanby (2001). Transcranial magnetic stimulation differentially affects speed and direction judgments. Experimental Brain Research, 140(4), 397-406. We also held one of the tasks (i.e., brightness discrimination) constant, while manipulating the stimuli, as described in the next panel.

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