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Why synthetic Biology?. Reverse Engineering vs. Forward engineering: Synthetic replicas of natural genetic circuits. 1) Why synthetic Biology?. Reverse Engineering vs. Forward engineering: Synthetic replicas of natural genetic circuits Test sufficiency of design of producing behavior

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why synthetic biology
Why synthetic Biology?
  • Reverse Engineering vs. Forward engineering:
          • Synthetic replicas of natural genetic circuits
1 why synthetic biology
1) Why synthetic Biology?
  • Reverse Engineering vs. Forward engineering:
          • Synthetic replicas of natural genetic circuits
          • Test sufficiency of design of producing behavior
          • Done without impairing cellular circuits
          • Compare different circuit designs that accomplish same function
  • Applications
          • Nanoscale materials
          • Cost effective production of anti malaria drugs
lessons learned
Lessons learned
  • Noise
  • Computation by simple circuits
  • ????
slide5

Rewiring signalling pathways. The pheromone and osmolarity response pathways in yeast

use protein scaffolds (Ste5 and Pbs2) to avoid crosstalk through the shared component Ste11.

By constructing a modified fusion protein of Pbs2 and Ste5, the authors constructed a rewired

pathway in which cells produce osmolarity stress responses after pheromone induction

2 conditions for a successful synthetic biology
2)Conditions for a Successful Synthetic Biology
  • Well characterized components
  • Modular (analogy to engineering)
  • Orthogonal to cellular processes
  • Robust circuit designs
  • Streamlined process
  • Standardization
  • Decoupling
3 previous work focused on transcriptional circuits
3) Previous work: focused on transcriptional circuits
  • Principles of noise suppression
  • Bistability
  • Oscillations
  • The benefits of feedback
  • Effect of delays
other mechanisms to design with
Other mechanisms to design with…
  • Protein Modifications
  • Regulated Degradation
  • microRNA
  • Diffusible molecules
  • ????
4 who do you think is suited to work in synthetic biology
4) Who do you think is suited to work in synthetic biology?
  • Biologists? Why?
  • Chemists? Why?
  • Engineers? Why?
5 what is the difference between engineered technological systems and biological systems
5) What is the difference between engineered technological systems and biological systems?

Evolution!!!

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