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Why synthetic Biology?. Reverse Engineering vs. Forward engineering: Synthetic replicas of natural genetic circuits. 1) Why synthetic Biology?. Reverse Engineering vs. Forward engineering: Synthetic replicas of natural genetic circuits Test sufficiency of design of producing behavior

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Why synthetic biology
Why synthetic Biology?

  • Reverse Engineering vs. Forward engineering:

    • Synthetic replicas of natural genetic circuits


1 why synthetic biology
1) Why synthetic Biology?

  • Reverse Engineering vs. Forward engineering:

    • Synthetic replicas of natural genetic circuits

    • Test sufficiency of design of producing behavior

    • Done without impairing cellular circuits

    • Compare different circuit designs that accomplish same function

  • Applications

    • Nanoscale materials

    • Cost effective production of anti malaria drugs


  • Lessons learned
    Lessons learned

    • Noise

    • Computation by simple circuits

    • ????


    Rewiring signalling pathways. The pheromone and osmolarity response pathways in yeast

    use protein scaffolds (Ste5 and Pbs2) to avoid crosstalk through the shared component Ste11.

    By constructing a modified fusion protein of Pbs2 and Ste5, the authors constructed a rewired

    pathway in which cells produce osmolarity stress responses after pheromone induction


    2 conditions for a successful synthetic biology
    2)Conditions for a Successful Synthetic Biology response pathways in yeast

    • Well characterized components

    • Modular (analogy to engineering)

    • Orthogonal to cellular processes

    • Robust circuit designs

    • Streamlined process

    • Standardization

    • Decoupling


    3 previous work focused on transcriptional circuits
    3) Previous work: focused on transcriptional circuits response pathways in yeast

    • Principles of noise suppression

    • Bistability

    • Oscillations

    • The benefits of feedback

    • Effect of delays


    Other mechanisms to design with
    Other mechanisms to design with… response pathways in yeast

    • Protein Modifications

    • Regulated Degradation

    • microRNA

    • Diffusible molecules

    • ????


    4 who do you think is suited to work in synthetic biology
    4) Who do you think is suited to work in synthetic biology? response pathways in yeast

    • Biologists? Why?

    • Chemists? Why?

    • Engineers? Why?


    5 what is the difference between engineered technological systems and biological systems
    5) What is the difference between engineered technological systems and biological systems?

    Evolution!!!


    Risks of building synthetic circuits
    Risks of building synthetic circuits? systems and biological systems?

    • Thoughts?


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