Why synthetic biology
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Why synthetic Biology?. Reverse Engineering vs. Forward engineering: Synthetic replicas of natural genetic circuits. 1) Why synthetic Biology?. Reverse Engineering vs. Forward engineering: Synthetic replicas of natural genetic circuits Test sufficiency of design of producing behavior

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Why synthetic Biology?

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Why synthetic Biology?

  • Reverse Engineering vs. Forward engineering:

    • Synthetic replicas of natural genetic circuits


1) Why synthetic Biology?

  • Reverse Engineering vs. Forward engineering:

    • Synthetic replicas of natural genetic circuits

    • Test sufficiency of design of producing behavior

    • Done without impairing cellular circuits

    • Compare different circuit designs that accomplish same function

  • Applications

    • Nanoscale materials

    • Cost effective production of anti malaria drugs


  • Lessons learned

    • Noise

    • Computation by simple circuits

    • ????


    Rewiring signalling pathways. The pheromone and osmolarity response pathways in yeast

    use protein scaffolds (Ste5 and Pbs2) to avoid crosstalk through the shared component Ste11.

    By constructing a modified fusion protein of Pbs2 and Ste5, the authors constructed a rewired

    pathway in which cells produce osmolarity stress responses after pheromone induction


    2)Conditions for a Successful Synthetic Biology

    • Well characterized components

    • Modular (analogy to engineering)

    • Orthogonal to cellular processes

    • Robust circuit designs

    • Streamlined process

    • Standardization

    • Decoupling


    3) Previous work: focused on transcriptional circuits

    • Principles of noise suppression

    • Bistability

    • Oscillations

    • The benefits of feedback

    • Effect of delays


    Other mechanisms to design with…

    • Protein Modifications

    • Regulated Degradation

    • microRNA

    • Diffusible molecules

    • ????


    4) Who do you think is suited to work in synthetic biology?

    • Biologists? Why?

    • Chemists? Why?

    • Engineers? Why?


    5) What is the difference between engineered technological systems and biological systems?

    Evolution!!!


    Risks of building synthetic circuits?

    • Thoughts?


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