Why synthetic biology
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Why synthetic Biology?. Reverse Engineering vs. Forward engineering: Synthetic replicas of natural genetic circuits. 1) Why synthetic Biology?. Reverse Engineering vs. Forward engineering: Synthetic replicas of natural genetic circuits Test sufficiency of design of producing behavior

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Why synthetic Biology?

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Why synthetic biology

Why synthetic Biology?

  • Reverse Engineering vs. Forward engineering:

    • Synthetic replicas of natural genetic circuits


1 why synthetic biology

1) Why synthetic Biology?

  • Reverse Engineering vs. Forward engineering:

    • Synthetic replicas of natural genetic circuits

    • Test sufficiency of design of producing behavior

    • Done without impairing cellular circuits

    • Compare different circuit designs that accomplish same function

  • Applications

    • Nanoscale materials

    • Cost effective production of anti malaria drugs


  • Lessons learned

    Lessons learned

    • Noise

    • Computation by simple circuits

    • ????


    Why synthetic biology

    Rewiring signalling pathways. The pheromone and osmolarity response pathways in yeast

    use protein scaffolds (Ste5 and Pbs2) to avoid crosstalk through the shared component Ste11.

    By constructing a modified fusion protein of Pbs2 and Ste5, the authors constructed a rewired

    pathway in which cells produce osmolarity stress responses after pheromone induction


    2 conditions for a successful synthetic biology

    2)Conditions for a Successful Synthetic Biology

    • Well characterized components

    • Modular (analogy to engineering)

    • Orthogonal to cellular processes

    • Robust circuit designs

    • Streamlined process

    • Standardization

    • Decoupling


    3 previous work focused on transcriptional circuits

    3) Previous work: focused on transcriptional circuits

    • Principles of noise suppression

    • Bistability

    • Oscillations

    • The benefits of feedback

    • Effect of delays


    Other mechanisms to design with

    Other mechanisms to design with…

    • Protein Modifications

    • Regulated Degradation

    • microRNA

    • Diffusible molecules

    • ????


    4 who do you think is suited to work in synthetic biology

    4) Who do you think is suited to work in synthetic biology?

    • Biologists? Why?

    • Chemists? Why?

    • Engineers? Why?


    5 what is the difference between engineered technological systems and biological systems

    5) What is the difference between engineered technological systems and biological systems?

    Evolution!!!


    Risks of building synthetic circuits

    Risks of building synthetic circuits?

    • Thoughts?


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