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PGD 與 Designer Babies PowerPoint PPT Presentation


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PGD 與 Designer Babies. 懷孕三個月的莫夫太太得了某種奇怪的疾病,醫生告訴她這種病毒會讓他的孩子一出生就失明。莫夫太太可以選擇墮胎,但是她決定把孩子生下來。 你認為她的決定道德正確嗎?. 如果情況有一點不同 …… 有一種價格一萬元的藥物可以保護她尚未出生的孩子,但莫夫太太最後決定不施行任何治療,並且把孩子生下來。 鎮上的布雷克神父嚴詞譴責,指出莫夫太太「讓小孩在生命的旅途上陷入不幸」。 莫夫太太則氣憤地回答,她並不想扮演小孩的上帝。 你認為她的決定道德正確嗎?. 父母是否有責任替孩子追求最大福祉?.

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PGD 與 Designer Babies

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PGDDesigner Babies





(preimplantation genetic diagnosis, PGD)

  • (assisted reproductive technology)

  • (invitro fertilization, IVF)


  • 1. ((monogenic disease)carrier)

  • 2. ()

  • 3. IVF () preimplantation genetic screening (PGS)PGD()


  • 1990

  • PCRY


  • 1.(biopsy)

  • 2.PGD

    PCR

    FISH

    comparative genomic hybridization


Polar-body Biopsy

1.

2.

3.


Cleavage State Biopsy

8~16-cell stage

Blastomerestotipotential

Prefered


Blastocyst Biopsy

1.cells

2.

3.


PCR (Polymerase chain reaction)

  • DNA


FISH (Fluorescent in situ hybridization)

DNA probes


Comparative Genomic Hybridization

  • ()


(Achondroplasia)

  • (131 / 124)O


(SS)

Ss

(similar problem: )


(Hemophilia)

  • X


  • (xY)(XX)(XY)


(Incontinentia Pigmenti)

X


PGD

50%

50%


(Huntington's Disease)

  • 35~50


  • HHxHH (HHxHh)

mock transfer()


(Fanconi anemia)


  • PGD(HLA-matching)/ ()

  • HLA-match(3/4)x(1/4) = 3/16PGD


Questions

PGD(family balancing)

(i.e. / )


Preimplantation genetic diagnosis

K Sermon, A Van Steirteghem, I Liebaers - The Lancet, 2004

Preimplantation genetic diagnosis

P Braude, S Pickering, F Flinter, CM Ogilvie - Nature Reviews Genetics, 2002

http://www.genes-at-taiwan.com.tw/genehelp/dbindex.asp

Wiki :Pedia


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